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Träfflista för sökning "L773:1573 1987 OR L773:1386 6184 "

Sökning: L773:1573 1987 OR L773:1386 6184

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1.
  • Karlsborn, Tony, 1987-, et al. (författare)
  • Loss of ncm5 and mcm5 wobble uridine side chains results in an altered metabolic profile
  • 2016
  • Ingår i: Metabolomics. - : Springer. - 1573-3882 .- 1573-3890. ; 12:12
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: The Elongator complex, comprising six subunits (Elp1p-Elp6p), is required for formation of 5-carbamoylmethyl (ncm(5)) and 5-methoxycarbonylmethyl (mcm(5)) side chains on wobble uridines in 11 out of 42 tRNA species in Saccharomyces cerevisiae. Loss of these side chains reduces the efficiency of tRNA decoding during translation, resulting in pleiotropic phenotypes. Overexpression of hypomodified tRNA(s2UUU)(Lys); tRNA(s2UUG)(Gln) and tRNA(s2UUC)(Glu), which in wild-type strains are modified with mcm(5)s(2)U, partially suppress phenotypes of an elp3 Delta strain. Objectives: To identify metabolic alterations in an elp3 Delta strain and elucidate whether these metabolic alterations are suppressed by overexpression of hypomodified tRNA(s2UUU)(Lys); tRNA(s2UUG)(Gln) and tRNA(s2UUC)(Glu). Method: Metabolic profiles were obtained using untargeted GC-TOF-MS of a temperature-sensitive elp3 Delta strain carrying either an empty low-copy vector, an empty high-copy vector, a low-copy vector harboring the wild-type ELP3 gene, or a high-copy vector overexpressing tRNA(s2UUU)(Lys); tRNA(s2UUG)(Gln) and tRNA(s2UUC)(Glu). The temperature sensitive elp3 Delta strain derivatives were cultivated at permissive (30 degrees C) or semi-permissive (34 degrees C) growth conditions. Results: Culturing an elp3 Delta strain at 30 or 34 degrees C resulted in altered metabolism of 36 and 46 %, respectively, of all metabolites detected when compared to an elp3D strain carrying the wild-type ELP3 gene. Overexpression of hypomodified tRNA(s2UUU)(Lys); tRNA(s2UUG)(Gln) and tRNA(s2UUC)(Glu) suppressed a subset of the metabolic alterations observed in the elp3 Delta strain. Conclusion: Our results suggest that the presence of ncm(5)- and mcm(5)-side chains on wobble uridines in tRNA are important for metabolic homeostasis.
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2.
  • Axsäter, Sven (författare)
  • Extension of the extended basic period approach for economic lot scheduling problems
  • 1987
  • Ingår i: Journal of Optimization Theory and Applications. - 0022-3239 .- 1573-2878. ; 52:No 2, s. 179-189
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper addresses the problem of choosing cyclical production patterns for several products which are produced on a common production facility. The extended basic period approach of Elmaghraby is extended by allowing more than two basic periods. The problem of dimensionality of the dynamic programming formulation is dealt with by aggregating the capacity data in different basic periods
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9.
  • Larsson, Per, et al. (författare)
  • Transport of polychlorinated biphenyls (PCBs) in freshwater mesocosms from sediment to water and air
  • 1987
  • Ingår i: Water, Air and Soil Pollution. - 0049-6979 .- 1573-2932. ; 36, s. 33-46
  • Tidskriftsartikel (refereegranskat)abstract
    • With sediment as a source the flux of PCBs to water and air was followed in mesocosms with and without fish for two vegetation seasons. The fish represented the largest lipid pool in the mesocosm, and their presence increased the flux of PCBs across the sediment/water interface. The flow of PCBs from sediment to water followed a seasonal pattern with higher rates during summer than in the winter. The rates were governed by the turbation activity of benthic invertebrates, the extent of gas production in the sediment, the amount and quality of the lipid pools in the water column, and the solubility of the PCBs. The greatest amount of PCBs among the lipid pools was found in the dissolved extractable lipids, which also showed the highest concentration of PCBs calculated on a lipid basis. After about 1.5 yr, >90% of the PCBs added was still in the sediment. The remainder was distributed within the mesocosms to various extents depending on the amount and quality of the lipid pools, or transferred into the air. Transfer into the air was governed by PCB concentrations in the water, and by water temperature. The flow was highest during summer, when the surface microlayer renewed its load of PCBs every 8th day. 
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10.
  • Maguire Jr., Gerald Q., et al. (författare)
  • Use of graphical techniques for error evaluation
  • 1987
  • Ingår i: Journal of medical systems. - : Springer. - 0148-5598 .- 1573-689X. ; 11:4, s. 277-286
  • Tidskriftsartikel (refereegranskat)abstract
    • Anatomic localization in functional (such as PET) imaging often requires a structural (such as CT or NMRI) study of the brain in the same plane. Some neuropsychiatric conditions make it difficult for a patient to hold his/her head immobile even when a rigid head holder is used. We studied the effect of tilt of the anatomic reference image, in this instance CT, relative to the functional image, here PET, on the quantification of receptor ligand concentration in anatomically defined regions of the brain.
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