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- Hallén, Anund
(författare)
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Gompertz law and aging as exclusion effects
- 2007
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Ingår i: Biogerontology (Dordrecht). - : Springer Science and Business Media LLC. - 1389-5729 .- 1573-6768. ; 8:5, s. 595-603
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Tidskriftsartikel (refereegranskat)abstract
- The exponential increase with age in mortality rate, the Gompertz law, indicates that the decrease in vitality and viability linked to aging depends on phenomena with exponential or logarithmic dynamics. Gompertz slope (α) is assumed to be a measure of aging rate, provided the studied cohort is homogeneous and in a supporting environment. The law provides no clue about the cause of aging, but may be formally correlated with various physical or mathematical functions. A possible correlation between the Ogston-Laurent exclusion equation and human aging is examined. An increase with age of an inert cross-linked insoluble protein network is assumed to result in a logarithmic decrease in water volume available to colloidal macromolecules. In this model, α is assumed to be a measure of the rate of accumulation of the polypeptide network.
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- Lagunas-Rangel, Francisco Alejandro
(författare)
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G protein-coupled receptors that influence lifespan of human and animal models
- 2022
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Ingår i: Biogerontology (Dordrecht). - Netherlands : Springer Netherlands. - 1389-5729 .- 1573-6768. ; 23:1, s. 1-19
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Forskningsöversikt (refereegranskat)abstract
- Humanity has always sought to live longer and for this, multiple strategies have been tried with varying results. In this sense, G protein-coupled receptors (GPCRs) may be a good option to try to prolong our life while maintaining good health since they have a substantial participation in a wide variety of processes of human pathophysiology and are one of the main therapeutic targets. In this way, we present the analysis of a series of GPCRs whose activity has been shown to affect the lifespan of animal and human models, and in which we put a special interest in describing the molecular mechanisms involved. Our compilation of data revealed that the mechanisms most involved in the role of GPCRs in lifespan are those that mimic dietary restriction, those related to insulin signaling and the AMPK and TOR pathways, and those that alter oxidative homeostasis and severe and/or chronic inflammation. We also discuss the possibility of using agonist or antagonist drugs, depending on the beneficial or harmful effects of each GPCR, in order to prolong people's lifespan and healthspan.
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- Lagunas-Rangel, Francisco Alejandro
(författare)
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Why do bats live so long? : Possible molecular mechanisms
- 2020
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Ingår i: Biogerontology (Dordrecht). - : Springer Science and Business Media LLC. - 1389-5729 .- 1573-6768. ; 21:1, s. 1-11
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Forskningsöversikt (refereegranskat)abstract
- Contrasting with several theories of ageing, bats are mammals with remarkable longevity despite their high metabolic rate, living on average three times more than other mammals of equal size. The question of how bats live a long time has attracted considerable attention, and they have thus been related to immortal fantasy characters like Dracula in the novel by Bram Stoker. Several ecological and physiological features, such as reduction in mortality risks, delayed sexual maturation and hibernation, have been linked to bats’ long lifespan. However, there is still very little information about the molecular mechanisms associated with the longevity of bats. In this regard, the present work tries to summarize current knowledge about how bats can live for so long, taking into consideration nutritional factors, oxidative metabolism, protein homeostasis, stress resistance, DNA repair, mitochondrial physiology and cancer resistance.
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