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| 2. |
- Kong, F, et al.
(författare)
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Telomerase as a "stemness" enzyme
- 2014
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Ingår i: Science China. Life sciences. - : Springer Science and Business Media LLC. - 1869-1889 .- 1674-7305. ; 57:6, s. 564-570
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Li, Chunyan, et al.
(författare)
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Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China
- 2012
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Ingår i: Science China Life Sciences. - : Springer Science+Business Media B.V.. - 1674-7305 .- 1869-1889. ; 55:12, s. 1057-1063
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Tidskriftsartikel (refereegranskat)abstract
- n this paper, we present the first evidence of differences in the mitochondria-related gene expression profiles of adult articular cartilage derived from patients with Kashin-Beck disease and normal controls. The expression of 705 mitochondria-related genes was analyzed by mitochondria-related gene expression analysis and ingenuity pathways analysis. Mitochondria-related gene expression analysis identified 9 up-regulated genes in Kashin-Beck disease based on their average expression ratio. Three canonical pathways involved in oxidative phosphorylation, apoptosis signaling and pyruvate metabolism were identified, which indicate the involvement of mitochondrial dysfunction in the pathogenesis of Kashin-Beck disease.
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| 4. |
- Li, Zhen, et al.
(författare)
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Morphology of living cells cultured on nanowire arrays with varying nanowire densities and diameters
- 2018
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Ingår i: Science China Life Sciences. - : Springer Science and Business Media LLC. - 1674-7305 .- 1869-1889. ; 61:4, s. 427-435
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Tidskriftsartikel (refereegranskat)abstract
- Vertical nanowire arrays are increasingly investigated for their applications in steering cell behavior. The geometry of the array is an important parameter, which influences the morphology and adhesion of cells. Here, we investigate the effects of array geometry on the morphology of MCF7 cancer cells and MCF10A normal-like epithelial cells. Different gallium phosphide nanowire array-geometries were produced by varying the nanowire density and diameter. Our results show that the cell size is smaller on nanowires compared to flat gallium phosphide. The cell area decreases with increasing the nanowire density on the substrate. We observed an effect of the nanowire diameter on MCF10A cells, with a decreased cell area on 40 nm diameter nanowires, compared to 60 and 80 nm diameter nanowires in high-density arrays. The focal adhesion morphology depends on the extent to which cells are contacting the substrate. For low nanowire densities and diameters, cells are lying on the substrate and we observed large focal adhesions at the cell edges. In contrast, for high nanowire densities and diameters, cells are lying on top of the nanowires and we observed point-like focal adhesions distributed over the whole cell. Our results constitute a step towards the ability to fine-tune cell behavior on nanowire arrays.
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| 5. |
- Liu, Yan-Jing, et al.
(författare)
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De novo assembly of white poplar genome and genetic diversity of white poplar population in Irtysh River basin in China
- 2019
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Ingår i: Science China Life Sciences. - : Springer Science and Business Media LLC. - 1674-7305 .- 1869-1889. ; 62:5, s. 609-618
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Tidskriftsartikel (refereegranskat)abstract
- The white poplar (Populus alba) is widely distributed in Central Asia and Europe. There are natural populations of white poplar in Irtysh River basin in China. It also can be cultivated and grown well in northern China. In this study, we sequenced the genome of P. alba by single-molecule real-time technology. De novo assembly of P. alba had a genome size of 415.99 Mb with a contig N50 of 1.18 Mb. A total of 32,963 protein-coding genes were identified. 45.16% of the genome was annotated as repetitive elements. Genome evolution analysis revealed that divergence between P. alba and Populus trichocarpa (black cottonwood) occurred similar to 5.0 Mya (3.0, 7.1). Fourfold synonymous third-codon transversion (4DTV) and synonymous substitution rate (ks) distributions supported the occurrence of the salicoid WGD event (similar to 65 Mya). Twelve natural populations of P. alba in the Irtysh River basin in China were sequenced to explore the genetic diversity. Average pooled heterozygosity value of P. alba populations was 0.170 +/- 0.014, which was lower than that in Italy (0.271 +/- 0.051) and Hungary (0.264 +/- 0.054). Tajima's D values showed a negative distribution, which might signify an excess of low frequency polymorphisms and a bottleneck with later expansion of P. alba populations examined.
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| 6. |
- Skyttä, Pietari, et al.
(författare)
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New zircon data supporting models of short-lived igneous activity at 1.89 Ga in the western Skellefte District, central Fennoscandian Shield
- 2011
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Ingår i: Solid Earth. - : Copernicus GmbH. - 1869-9510 .- 1869-9529. ; 2, s. 205-217
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Tidskriftsartikel (refereegranskat)abstract
- New U-Th-Pb zircon data (SIMS) from three intrusive phases of the Palaeoproterozoic Viterliden intrusion in the western Skellefte District, central Fennoscandian Shield, dates igneous emplacement in a narrow time interval at about 1.89 Ga. A locally occurring quartz-plagioclase porphyritic tonalite, here dated at 1889 ± 3 Ma, is considered the youngest of the intrusive units, based on the new age data and field evidence. This supports an existing interpretation of its fault-controlled emplacement after intrusion of the dominating hornblende-tonalite units, in this study dated at 1892 ± 3 Ma. The Viterliden magmatism was synchronous with the oldest units of the Jörn type early-orogenic intrusions in the eastern part of the district (1.89–1.88 Ga; cf. Gonzàles Roldán, 2010). A U-Pb zircon age for a felsic metavolcanic rock from the hanging-wall to the Kristineberg VMS deposit, immediately south of the Viterliden intrusion, is constrained at 1883 ± 6 Ma in this study. It provides a minimum age for the Kristineberg ore deposit and suggests contemporaneous igneous/volcanic activity throughout the Skellefte District. Furthermore, it supports the view that the Skellefte Group defines a laterally continuous belt throughout this "ore district". Tentative correlation of the 1889 ± 3 Ma quartz-plagioclase porphyritic tonalite with the Kristineberg "mine porphyry" suggests that these units are coeval at about 1.89 Ga. Based on the new age determinations, the Viterliden intrusion may equally well have intruded into or locally acted as a basement for the ore-hosting Skellefte Group volcanic rocks.
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