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- Bengmark, Stig, et al.
(författare)
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Advanced glycation and lipoxidation end products - Amplifiers of inflammation: The role of food
- 2007
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Ingår i: Nutrición Hospitalaria. - 1699-5198. ; 22:6, s. 625-640
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Forskningsöversikt (refereegranskat)abstract
- Chronic diseases (CD) represent the main cause of mortality in developed countries. The increase in the prevalence of of CD is associated with changes in lifestyle habits, including those related to the consumption of processed foodstuffs. In these foods advanced glycation end products (AGE) and advanced lipoperoxydation products (ALE) are formed as a consequence of the reactivity of proteins, carbohydrates, lipid and other components. The aim of the present review is to offer a perspective of how AGE and ALE. affect the physiology and development of CD. Continous intake of AGE and ALE contributes to the exccesive accumulation of these products into body tissues, which in turn negatively influence the innate immune system, inflammatory responses, and resistance to diseases. This is achieved by direct interaction of AGE and ALE with specific cell AGE receptors (RAGE) that have a key role as master switches regulating the development of CD. Long-life molecules, namely collagen and myelin, and low-turnover tissues, e.g. connective, bone and neural tissues,are the main targets of AGE and ALE. In these tissues, AGE and ALE lead to the synthesis of insoluble compounds that severely alter cellular functionality. It has been reported associations of AGE and ALE with allergic and autoimmune diseases, Alzheimer disease and other degenerative disorders, catarats, atherosclerosis, cancer, and diabetes mellitus type 2, as well as a number of endocrine, gastrointestinal, skeleton-muscle, and urogenital alterations. Controlling all those pathologies would need further dietary recommendations aiming to limit the intake of processed foods rich in AGE and ALE, as well as to reduce the formation of those products by improving technological processes applicable to foods.
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- Bengmark, Stig
(författare)
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Modulation by enteral nutrition of the acute phase response and immune functions.
- 2003
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Ingår i: Nutrición Hospitalaria. - 1699-5198. ; 18:1, s. 1-5
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Tidskriftsartikel (refereegranskat)abstract
- To use nutrition in order to limit the negative consequences of physical and mental stress is not new. Recent advances in immunology and particularly in the understanding of the chemical language used to communicate both by eukarytic and prokarotic cells has made it easier to objectively evaluate effects of various immunomodulating efforts including the use of nutrients, vitamins and antioxidants in preventing or limiting the development of disease and its late consequences.
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- Hammes, T. O., et al.
(författare)
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Lactobacillus rhamnosus GG reduces hepatic fibrosis in a model of chronic liver disease in rats
- 2017
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Ingår i: Nutricion Hospitalaria. - : ARAN Ediciones. - 0212-1611 .- 1699-5198. ; 34:3, s. 702-709
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Tidskriftsartikel (refereegranskat)abstract
- Background: The intestinal dysbiosis is common in chronic liver disease and can induce to inflammatory responses and mediate the collagen deposition in the liver. Aim: To evaluate the probiotic Lactobacillus rhamnosus GG (LGG) for the treatment of liver fibrosis in a model of chronic cholestatic liver disease in rats. Methods: Male adult Wistar rats (n = 29) were submitted to common bile duct ligation (BDL groups) or manipulation of common bile duct without ligation (Ctrl groups).Two weeks after surgery, each group was randomly divided to receive 1 ml of PBS (Ctrl and BDL) or PBS containing 2.5 x 10(7) CFU of LGG (Ctrl-P and BDL-P) through gavages for 14 days. Euthanasia occurred 33 days after surgery when samples of blood and liver tissue were collected. Results: The hepatic gene expression of Tlr4, Tnf alpha, IL-6, Tgf beta, and metalloproteinase-2 and -9 were higher in the BDL groups in comparison to Ctrl. The ductular reaction evaluated by immunocontent of cytokeratin-7 (CK7) and the content of collagen were increased in BDL groups. Also, there was an imbalance in the antioxidant defenses (superoxide dismutase and catalase) and an increase in the oxidative stress marker sulfhydryl in BDL groups. The treatment with LGG significantly reduced gene expression of IL-6, collagen deposition, and ductular reaction in hepatic tissue of animals from BDL-P groups. Conclusion: The treatment with the probiotic LGG was able to reduce liver fibrosis, ductular reaction, and hepatic gene expression of IL-6 in a model of cholestatic liver disease in rats.
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- Ljungqvist, Olle, 1954-, et al.
(författare)
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Under nutrition : a major health problem in Europe
- 2009
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Ingår i: Nutrición Hospitalaria. - Madrid, Spanien : Aula Medica Ediciones. - 0212-1611 .- 1699-5198. ; 24:3, s. 369-70
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Tidskriftsartikel (refereegranskat)
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