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- Dahlbäck, Björn, et al.
(författare)
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Apolipoprotein M: structure and function
- 2008
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Ingår i: Future Lipidology. - : Informa UK Limited. - 1746-0875. ; 3:5, s. 495-503
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Forskningsöversikt (refereegranskat)abstract
- Lipoproteins in blood play an important physiological role transporting cholesterol, lipids and lipid-soluble substances to the different organs of the body. Diseases such as atherosclerosis, cardiovascular disease and stroke are associated with defects in lipoprotein metabolism. For many years, intense research has focused on the role of cholesterol in development of atherosclerosis. Cholesterol is transported in both LDL and HDL; increased concentrations of LDL-C are associated with atherosclerosis, whereas high HDL-C is considered to be protective against development of atherosclerosis. Apolipoproteins Al and B are the major proteins of HDL and LDL, respectively. In HDL, a large number of additional proteins with important functions have been identified. A late addition to the list of HDL-associated proteins is apoM, the structure and function of which are the topic of this review.
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| 4. |
- Nilsson, Jan, et al.
(författare)
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Oxidized lipoprotein autoimmunity: an emerging drug target in cardiovascular disease
- 2006
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Ingår i: Future Lipidology. - : Informa UK Limited. - 1746-0875. ; 1:3, s. 321-330
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Forskningsöversikt (refereegranskat)abstract
- Oxidative modification of low-density lipoprotein (LDL) in the arterial wall is believed to be one of the most important mechanisms involved in the development of atherosclerosis. It is well established that oxidized (Ox)-LDL uptake is responsible for the formation of macrophage foam cells, one of the most characteristic hallmarks of the atherosclerotic plaque, and that the proinflammatory and cytotoxic effects of Ox-LDL play an important role in vascular inflammation and lesion development. More recently, it has become apparent that Ox-LDL is also recognized by the immune system, thus resulting in innate and adaptive immune reactions modulating both Ox-LDL clearance and the vascular inflammatory response. The finding that some of these immune responses have a protective effect against plaque development has focused attention on the potential to develop novel therapies for the prevention and treatment of cardiovascular disease based on the selective activation of this protective immunity by vaccines, or mimicking them directly by using Ox-LDL-specific antibodies.
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| 5. |
- Norlin, Maria
(författare)
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Regulation of cellular steroid levels with special focus on oxysterol and estrogen metabolism
- 2008
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Ingår i: Future Lipidology. - : Informa UK Limited. - 1746-0875. ; 3:3, s. 337-346
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Forskningsöversikt (refereegranskat)abstract
- Steroids play essential roles in a number of physiological systems. However, disturbed functions or abnormal levels of steroids can result in serious health problems. The cellular levels of steroids are regulated by enzymes and other factors that control the formation and elimination of these compounds. Recent findings on steroid action and metabolism have identified novel links between two groups of steroids, oxysterols and estrogens. A better understanding of cellular processes related to these steroids is of interest for developing future therapies in several conditions, including endocrine tumors and hyperlipidemia.
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