| 1. |
- Amer-Wåhlin, Isis, et al.
(författare)
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ST analysis of fetal electrocardiography in labor
- 2011
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Ingår i: Seminars in Fetal & Neonatal Medicine. - : Elsevier BV. - 1878-0946 .- 1744-165X. ; 16:1, s. 29-35
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Tidskriftsartikel (refereegranskat)abstract
- Since its introduction more than 40 years ago, electronic fetal monitoring has become widely used for intrapartum surveillance to determine fetal wellbeing in labor. Although fetal hypoxia and acidosis are reflected in changes in fetal heart rate, there is no evidence that cardiotocography has been effective in reducing neonatal morbidity related to fetal distress occurring during labor. Indeed the specificity of this tool is poor and in many instances the incorporation of electronic fetal monitoring into intrapartum care has merely led to an increase in medical intervention rather than an improvement in neonatal outcome. Fetal electrocardiography (ECG) analysis provides an additional method for assessing the response of the fetus to hypoxia and in particular to the development of metabolic acidosis. ST changes in the fetal ECG can be quantified with computational analysis, reducing subjective interpretation that has been problematic with traditional electronic fetal monitoring. Formal algorithms indicating appropriate points for intervention in labor have been designed. The fetal ECG has been shown to be a useful adjunct to traditional electronic fetal monitoring in several randomized controlled trials with evidence of reduced rates of neonatal encephalopathy and reduced rates of obstetric intervention. (C) 2010 Elsevier Ltd. All rights reserved.
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| 2. |
- Anderlid, BM, et al.
(författare)
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Clinical perinatal genetics
- 2011
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Ingår i: Seminars in fetal & neonatal medicine. - : Elsevier BV. - 1878-0946 .- 1744-165X. ; 16:2, s. 69-69
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Barbaro, M, et al.
(författare)
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Disorders of sex development
- 2011
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Ingår i: Seminars in fetal & neonatal medicine. - : Elsevier BV. - 1878-0946 .- 1744-165X. ; 16:2, s. 119-127
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Tidskriftsartikel (refereegranskat)
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| 4. |
- Chalak, L., et al.
(författare)
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Bedside and laboratory neuromonitoring in neonatal encephalopathy
- 2021
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Ingår i: Seminars in Fetal & Neonatal Medicine. - : Elsevier. - 1744-165X .- 1878-0946. ; 26:5
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Forskningsöversikt (refereegranskat)abstract
- Several bedside and laboratory neuromonitoring tools are currently used in neonatal encephalopathy (NE) to assess 1) brain function [amplitude-integrated electroencephalogram (aEEG) and EEG], 2) cerebral oxygenation delivery and consumption [near-infrared spectroscopy (NIRS)] and 3) blood and cerebrospinal fluid biomarkers. The aim of the review is to provide the role of neuromonitoring in understanding the development of brain injury in these newborns and better predict their long-term outcome. Simultaneous use of these monitoring modalities may improve our ability to provide meaningful prognostic information regarding ongoing treatments. Evidence will be summarized in this review for each of these modalities, by describing (1) the methods, (2) the clinical evidence in context of NE both before and with hypothermia, and (3) the research and future directions.
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| 5. |
- Diaz, Francisca, et al.
(författare)
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Mitochondrial disorders caused by mutations in respiratory chain assembly factors
- 2011
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Ingår i: Seminars in Fetal & Neonatal Medicine. - : Elsevier BV. - 1878-0946 .- 1744-165X. ; 16:4, s. 197-204
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Tidskriftsartikel (refereegranskat)abstract
- Mitochondrial diseases involve the dysfunction of the oxidative phosphorylation (OXPHOS) system. This group of diseases presents with heterogeneous clinical symptoms affecting mainly organs with high energy demands. Defects in the multimeric complexes comprising the OXPHOS system have a dual genetic origin, mitochondrial or nuclear DNA. Although many nuclear DNA mutations involve genes coding for subunits of the respiratory complexes, the majority of mutations found to date affect factors that do not form part of the final complexes. These assembly factors or chaperones have multiple functions ranging from cofactor insertion to proper assembly/stability of the complexes. Although significant progress has been made in the last few years in the discovery of new assembly factors, the function of many remains elusive. Here, we describe assembly factors or chaperones that are required for respiratory chain complex assembly and their clinical relevance. (C) 2011 Elsevier Ltd. All rights reserved.
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| 6. |
- Eriksson, Mats, Professor, 1959-, et al.
(författare)
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Assessment of pain in newborn infants
- 2019
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Ingår i: Seminars in Fetal & Neonatal Medicine. - : Saunders Elsevier. - 1744-165X .- 1878-0946. ; 24:4
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Tidskriftsartikel (refereegranskat)abstract
- Hospitalized newborn infants experience pain that can have negative short- and long-term consequences and thus should be prevented and treated. National and international guidelines state that adequate pain management requires valid pain assessment. Nociceptive signals cause a cascade of physical and behavioral reactions that alone or in combination can be observed and used to assess the presence and intensity of pain.Units that are caring for newborn infants must adopt sufficient pain assessment tools to cover the gestational ages and pain types that occurs in their setting. Pain assessment should be performed on a regular basis and any detection of pain should be acted on. Future research should focus on developing and validating pain assessment tools for specific situations.
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| 7. |
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| 8. |
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| 9. |
- Fellman, Vineta, et al.
(författare)
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Cortical auditory event-related potentials in newborn infants.
- 2006
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Ingår i: Seminars in Fetal & Neonatal Medicine. - : Elsevier BV. - 1878-0946 .- 1744-165X. ; 11:6, s. 452-458
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Tidskriftsartikel (refereegranskat)abstract
- The possibility of recording changes in electroencephalography potentials following perception of sound was reported several decades ago. The recent expanding research on auditory cortical event-retated potentials (AERPs) for assessing sound discrimination abilities in children and infants has indicated that several methodological issues need to be addressed before it can be implemented in clinical practice. Latencies, polarities, and amplitudes of the responses change with gestational age and during infancy. Thus, the maturation of the infant must be considered when designing stimulus paradigms and interpreting the responses. Of healthy newborn infants, only about 80% will show mismatch negativity, the automatic change detection of the auditory stimuli. Currently, the AERP method cannot be applied in clinical practice in the neonatal period, although the findings in healthy newborns at risk for dyslexia are promising. Further research will elucidate the possibility of developing AERPs as a possible early screening method during infancy for later dyslexia or cognitive dysfunction.
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| 10. |
- Fellman, Vineta, et al.
(författare)
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Mitochondrial disorders in the perinatal period
- 2011
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Ingår i: Seminars in Fetal & Neonatal Medicine. - : Elsevier BV. - 1878-0946 .- 1744-165X. ; 16:4, s. 173-174
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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