| 1. |
- Söderhäll, Kenneth, et al.
(författare)
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Role of the prophenoloxidase-activating system in invertebrate immunity
- 1998
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Ingår i: Current Opinion in Immunology. - 0952-7915 .- 1879-0372. ; 10:1, s. 23-28
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Tidskriftsartikel (refereegranskat)abstract
- The melanization reaction, which is a common response to parasite entry in invertebrate animals, especially arthropods, is due to the activity of an oxidoreductase, phenoloxidase. This enzyme is part of a complex system of proteinases, pattern recognition
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| 2. |
- Apcher, Sebastien, et al.
(författare)
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In search of the cell biology for self- versus non-self- recognition
- 2023
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Ingår i: Current Opinion in Immunology. - 0952-7915 .- 1879-0372. ; 83
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Forskningsöversikt (refereegranskat)abstract
- Several of today's cancer treatments are based on the immune system's capacity to detect and destroy cells expressing neoantigens on major histocompatibility class-I molecules (MHC-I). Despite this, we still do not know the cell biology behind how antigenic peptide substrates (APSs) for the MHC-I pathway are produced. Indeed, there are few research fields with so many divergent views as the one concerning the source of APSs. This is quite remarkable considering their fundamental role in the immune systems’ capacity to detect and destroy virus-infected or transformed cells. A better understanding of the processes generating APSs and how these are regulated will shed light on the evolution of self-recognition and provide new targets for therapeutic intervention. We discuss the search for the elusive source of MHC-I peptides and highlight the cell biology that is still missing to explain how they are synthesised and where they come from.
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| 3. |
- Apcher, Sebastien, et al.
(författare)
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The source of MHC class I presented peptides and its implications
- 2016
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Ingår i: Current Opinion in Immunology. - : Elsevier BV. - 0952-7915 .- 1879-0372. ; 40, s. 117-122
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Forskningsöversikt (refereegranskat)abstract
- The source of peptides that enter the major histocompatibility class I (MHCI) pathway has been intensively debated over the last two decades. The initial assumption that peptides are derived from degradation of full length proteins was challenged by a model in which alternative translation products are a source of peptides. This model has been tested and supported by scientific data. We now need new hypotheses on the physiological implications of different sources of peptides for the MHCI pathway. The aim of this overview is to give an up-todate account of the source of antigenic peptide material for the MHCI pathway and to incorporate the more recent observations of alternative mRNA translation products into existing models of the direct and cross-presentation pathways.
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| 4. |
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| 5. |
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| 6. |
- Bryder, David, et al.
(författare)
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Shaping up a lineage-lessons from B lymphopoesis
- 2010
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Ingår i: CURRENT OPINION IN IMMUNOLOGY. - : Elsevier Science B.V., Amsterdam.. - 0952-7915 .- 1879-0372. ; 22:2, s. 148-153
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Forskningsöversikt (refereegranskat)abstract
- Even though the development of B lymphoid cells from hematopoietic stem cells is one of the most carefully investigated models of cell differentiation in adult mammalians, a set of recent findings has to a large extent increased our understanding for how B lymphoid commitment is achieved. These include the identification of IKAROS, PU.1 and E2A as transcription factors responsible for lymphoid lineage priming in multipotent cells, as well as the identification of EBF1 dependent B lineage restricted progenitors among cells lacking expression of the classical B lineage markers CD19 or 8220. The insight that the B cell identity may be defined at an earlier stage then previously thought, allows for an increased understanding of B lymphoid development likely to unravel molecular mechanisms of high relevance also for other differentiation processes within as well as outside of the hematopoietic system.
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| 7. |
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| 8. |
- Delgado-Vega, Angelica, et al.
(författare)
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Recent findings on genetics of systemic autoimmune diseases
- 2010
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Ingår i: Current Opinion in Immunology. - : Elsevier BV. - 0952-7915 .- 1879-0372. ; 22:6, s. 698-705
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Forskningsöversikt (refereegranskat)abstract
- Association studies of over 1 million SNPs capturing most of the human genome common variation became possible thanks to the information provided by the HapMap International project and the development of high-throughput genotyping technologies at accessible prices. Genome-wide scans analyzing thousands of individuals have now identified most if not all of the major genes involved in susceptibility for several systemic autoimmune diseases. In particular, results for rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc) are reviewed here. While most genes are shared between diseases, few seem to be unique reflecting that we still are long before knowing all genes, their interactions with other genes and the environment and their impact on biological functions.
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| 9. |
- Flodstrom-Tullberg, M, et al.
(författare)
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Natural killer cells in human autoimmunity
- 2009
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Ingår i: Current opinion in immunology. - : Elsevier BV. - 1879-0372 .- 0952-7915. ; 21:6, s. 634-640
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Tidskriftsartikel (refereegranskat)
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| 10. |
- Jensen, Christina, et al.
(författare)
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Exploring the multifaceted nature of the common lymphoid progenitor compartment.
- 2016
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Ingår i: Current Opinion in Immunology. - : Elsevier BV. - 1879-0372 .- 0952-7915. ; 39, s. 121-126
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Forskningsöversikt (refereegranskat)abstract
- While the common lymphoid progenitor compartment was originally thought to be a rather homogenous cell population, it has become increasingly clear that this compartment is highly heterogeneous both with regard to phenotypic and functional features. The exploration of this cellular complexity has generated novel molecular insights into regulatory events in lymphoid lineage restriction and provided support for the idea that multiple lineage restriction events occur at this developmental stage. Furthermore, the identification of multiple lineage-restricted progenitors with mixed lineage potential challenges a strictly hierarchical model for lymphoid development. Instead we propose a model based on competence windows during which cell fates are established through the action of lineage determining factors.
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