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- Fadeel, B., et al.
(författare)
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Bridge over troubled waters : Understanding the synthetic and biological identities of engineered nanomaterials
- 2013
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Ingår i: Wiley Interdisciplinary Reviews. - : Wiley. - 1939-5116 .- 1939-0041. ; 5:2, s. 111-129
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Tidskriftsartikel (refereegranskat)abstract
- Engineered nanomaterials offer exciting opportunities for 'smart' drug delivery and in vivo imaging of disease processes, as well as in regenerative medicine. The ability to manipulate matter at the nanoscale enables many new properties that are both desirable and exploitable, but the same properties could also give rise to unexpected toxicities that may adversely affect human health. Understanding the physicochemical properties that drive toxicological outcomes is a formidable challenge as it is not trivial to separate and, hence, to pinpoint individual material characteristics of nanomaterials. In addition, nanomaterials that interact with biological systems are likely to acquire a surface corona of biomolecules that may dictate their biological behavior. Indeed, we propose that it is the combination of material-intrinsic properties (the 'synthetic identity') and context-dependent properties determined, in part, by the bio-corona of a given biological compartment (the 'biological identity') that will determine the interactions of engineered nanomaterials with cells and tissues and subsequent outcomes. The delineation of these entwined 'identities' of engineered nanomaterials constitutes the bridge between nanotoxicological research and nanomedicine.
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| 5. |
- Hilborn, Jöns
(författare)
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In vivo injectable gels for tissue repair
- 2011
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Ingår i: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. - : Wiley. - 1939-5116. ; 3:6, s. 589-606
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Forskningsöversikt (refereegranskat)abstract
- The desire to reduce healthcare costs while improving outcomes drives minimally invasive methods to replacing traditional surgical procedures. Various treatments that would previously have needed open-type surgeries can be carried out using endoscopes, catheters, and needles. These advantages have become especially obvious for tissue engineering and regenerative medicine with in vivo gel injectable nanomaterials. In this review, the state of the art in this rapidly developing field is given. This is done by contrasting functional evaluation in vitro with in vivo followed by describing (1) synthetic materials, (2) the body's own polymers, (3) polymers in nature, (4) self-assembled peptides, and (5) new innovations and combinations. With increased understanding of the relationship between material characteristics and the outcome in vivo more rational design criteria are emerging.
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| 6. |
- Hurtig, Johan, et al.
(författare)
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Intercellular nanotubes : insights from imaging studies and beyond
- 2010
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Ingår i: WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY. - : Wiley. - 1939-5116 .- 1939-0041. ; 2:3, s. 260-276
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Forskningsöversikt (refereegranskat)abstract
- Cell-cell communication is critical to the development, maintenance, and function of multicellular organisms. Classical mechanisms for intercellular communication include secretion of molecules into the extracellular space and transport of small molecules through gap junctions. Recent reports suggest that cells also can communicate over long distances via a network of transient intercellular nanotubes. Such nanotubes have been shown to mediate intercellular transfer of organelles as well as membrane components and cytoplasmic molecules. Moreover, intercellular nanotubes have been observed in vivo and have been shown to enhance the transmission of pathogens such as human immunodeficiency virus (HIV)-1 and prions in vitro. These studies indicate that intercellular nanotubes may play a role both in normal physiology and in disease. (C) 2010 John Wiley & Sons, Inc. WIREs Nanomed Nanobiotechnol 2010 2 260-276
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| 7. |
- Sharma, Hari Shanker, et al.
(författare)
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Nanowired drug delivery for neuroprotection in central nervous system injuries : modulation by environmental temperature, intoxication of nanoparticles, and comorbidity factors
- 2012
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Ingår i: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. - : Wiley. - 1939-5116. ; 4:2, s. 184-203
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Forskningsöversikt (refereegranskat)abstract
- Recent developments in nanomedicine resulted in targeted drug delivery of active compounds into the central nervous system (CNS) either through encapsulated material or attached to nanowires. Nanodrug delivery by any means is supposed to enhance neuroprotection due to rapid accumulation of drugs within the target area and a slow metabolism of the compound. These two factors enhance neuroprotection than the conventions drug delivery. However, this is still uncertain whether nanodrug delivery could alter the pharmacokinetics of compounds making it more effective or just longer exposure of the compound for extended period of time is primarily responsible for enhanced effects of the drugs. Our laboratory is engaged in understanding of the nanodrug delivery using TiO2 nanowires in CNS injuries models, for example, spinal cord injury (SCI), hyperthermia and/or intoxication of nanoparticles with or without other comorbidity factors, that is, diabetes or hypertension in rat models. Our observations suggest that nanowired drug delivery is effective under normal situation of SCI and hyperthermia as evidenced by significant reduction in the bloodbrain barrier (BBB) breakdown, brain edema formation, cognitive disturbances, neuronal damages, and brain pathologies. However, when the pathophysiology of these CNS injuries is aggravated by nanoparticles intoxication or comorbidity factors, adjustment in dosage of nanodrug delivery is needed. This indicates that further research in nanomedicine is needed to explore suitable strategies in achieving greater neuroprotection in CNS injury in combination with nanoparticles intoxication or other comorbidity factors for better clinical practices.
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| 8. |
- Strømme, Maria, 1970-, et al.
(författare)
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Mesoporous silica-based nanomaterials for drug delivery : evaluation of structural properties associated with release rate
- 2009
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Ingår i: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. - : Wiley. - 1939-5116. ; 1:1, s. 140-148
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Tidskriftsartikel (refereegranskat)abstract
- We present here a study of the controlled release of amino acid-derived amphiphilic molecules from the internal pore structure of mesoporous nanoparticle drug delivery systems with different structural properties, namely cubic and hexagonal structures of various degrees of complexity. The internal pore surface of the nanomaterials presented has been functionalised with amine moieties through a one-pot method. Release profiles obtained by conductivity measurements are interpreted in terms of specific structural and textural parameters of the porous nanoparticles, such as pore geometry and connectivity. Results indicate that diffusion coefficients are lower by as much 4 orders of magnitude in two-dimensional structures in comparison to three-dimensional mesoporous solids. A fast release in turn is observed from mesocaged materials AMS-9 and AMS-8, where the presence of structural defects is thought to lead to a slightly lower diffusion coefficient in the latter. We conclude that the use of single or mixed phases of these porous systems can be utilized to provide sustained release over long time periods and expect their use in a variety of formulations.
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| 9. |
- Tarakanov, A. O., et al.
(författare)
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Carbon nanotubes towards medicinal biochips
- 2010
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Ingår i: Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. - : Wiley. - 1939-0041 .- 1939-5116. ; 2:1, s. 1-10
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Tidskriftsartikel (refereegranskat)abstract
- Carbon nanotubes (CNTs) exhibit a unique combination of biological and physical properties.(1-3) These properties make CNT-based devices, especially CNT field-effect transistors (FETs),(3,4) promising as a novel platform for chemical sensors,(5) biosensors,(6-8) and biochips.(9-11) The last ones seem to be especially promising for clinical diagnostics.(12) Namely, biochips permit the analysis of DNA, proteins, and other biological and chemical molecules in a massively parallel format.(13) They represent a multidisciplinary development unifying molecular biology, chemical and electronics engineering.(14) The emerging technologies of CNT biochips in medicine might provide further advantages relative to traditional biochip platforms including the cost and speed of medical tests.(12,15,16) Accordingly, our overview focuses on the recent advances in CNT-based biochips and tries to clarify their medicinal potential including lab-on-chips for molecular diagnostics,(17,18) drug screening,(19) and also novel strategies in molecular medicine.(20-22)
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