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- Augustsson, Cecilia, et al.
(författare)
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A nonneutralizing antibody as cause of prothrombin deficiency in a patient with follicular lymphoma
- 2024
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Ingår i: Clinical Case Reports. - : WILEY. - 2050-0904. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Acquired inhibitors of blood coagulation are rare but of clinical importance. Prothrombin is a vitamin K-dependent protein, and acquired antibodies toward prothrombin are often associated with the presence of lupus anticoagulant. We describe a previously healthy 70-year-old man presenting with both hemorrhage and thrombosis as well as a prolonged prothrombin time. At arrival at the hospital, he was diagnosed with deep venous thrombosis, and an enlarged lymph node in the left groin was noted (revealed as follicular lymphoma grade 1 by biopsy). Prothrombin activity and antibody titer were followed for 5 months with 15 sampling time points to monitor the treatment outcome of the patient. Diagnostic work-up identified prothrombin deficiency as cause of bleeding. A nonneutralizing calcium-dependent antiprothrombin antibody was found, suspected to increase the clearance of prothrombin, which has previously only occasionally been reported. Lupus anticoagulant was ruled out and thrombosis was judged to be caused by a combination of malignant disease and stagnant venous flow following enlarged lymph nodes in the groin. This report illustrates how investigation of prolonged global coagulation tests, triggered the diagnosis of a rare but critical condition, immune-mediated prothrombin deficiency. The diagnosis is challenging and involves proper differential diagnosis. image
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- Baliakas, Panagiotis, 1977-, et al.
(författare)
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Refractory chronic "ITP" : When platelet size matters
- 2018
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Ingår i: Clinical Case Reports. - : Wiley. - 2050-0904. ; 6:9, s. 1779-1780
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Tidskriftsartikel (refereegranskat)abstract
- Key Clinical Message Inherited conditions associated with thrombocytopenia should be included in the differential diagnosis of young patients with refractory immune thrombocytopenia (ITP), even in the absence of a positive family history. Early identification of such conditions is of vital importance in order to reach the right diagnosis and avoid unnecessary or even harmful medication.
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- Belayneh, Dereje K., et al.
(författare)
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Asymptomatic giant right coronary artery aneurysm in Kawasaki disease : A case report
- 2020
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Ingår i: Clinical Case Reports. - : John Wiley & Sons. - 2050-0904. ; 8:12, s. 2732-2738
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Tidskriftsartikel (refereegranskat)abstract
- Incidentally diagnosed giant coronary artery aneurysms (gCAA) exceeding 50 mm in diameter are extremely rare and carry increased risks of cardiovascular morbidity and mortality. Currently, surgery is the preferred treatment for such gCAA.
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| 7. |
- Belayneh, Dereje K., et al.
(författare)
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Thyrotoxic hypokalemic periodic paralysis in an African male : a case report
- 2015
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Ingår i: Clinical Case Reports. - Hoboken, USA : Wiley-Blackwell. - 2050-0904. ; 3:2, s. 102-105
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Tidskriftsartikel (refereegranskat)abstract
- Thyrotoxic hypokalemic periodic paralysis is a rare manifestation of thyrotoxicosis and is rarely reported in non-Asian populations. A 26-year-old Ethiopian male who presented with recurrent flaccid tetraparesis, hypokalemia, and hyperthyroidism is reported here. Thyroid function should be routinely checked in patients with acute or recurrent hypokalemic paralysis.
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- Björkenstam, Marie, et al.
(författare)
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Case report of eosinophilic granulomatosis with polyangitis presenting as acute myocarditis.
- 2022
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Ingår i: Clinical case reports. - : Wiley. - 2050-0904. ; 10:10
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Tidskriftsartikel (refereegranskat)abstract
- This case presents a challenging diagnosis of EGPA presenting as eosinophilic myocarditis. It is a condition that can mimic many other diseases and where prompt diagnosis and early treatment is essential for recovery. The diagnosis was made after an endomyocardial biopsy (EMB) and showed the importance of EMB in the diagnostic work-up.
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