| 1. |
- Bajc, Marika, et al.
(författare)
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Ventilation/Perfusion SPECT for Diagnosis of Pulmonary Embolism and Other Diseases.
- 2011
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Ingår i: International Journal of Molecular Imaging. - : Hindawi Limited. - 2090-1712 .- 2090-1720. ; 2011:Dec 19
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Tidskriftsartikel (refereegranskat)abstract
- V/P(SPECT) has the potential to become a first hand tool for diagnosis of pulmonary embolism based on standardized technology and new holistic interpretation criteria. Pretest probability helps clinicians choose the most appropriate objective test for diagnosis or exclusion of PE. Interpretation should also take into account all ventilation and perfusion patterns allowing diagnosis of other cardiopulmonary diseases than PE. In such contexts, V/P(SPECT) has excellent sensitivity and specificity. Nondiagnostic reports are ≤3%. V/P(SPECT) has no contraindication; it is noninvasive and has very low radiation exposure. Moreover, acquisition time for V/P(SPECT) is only 20 minutes. It allows quantification of PE extension which has an impact on individual treatment. It is uniquely useful for followup and research.
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| 2. |
- Lindhe, Örjan, et al.
(författare)
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Autoradiographic mapping of 5-HT1B/1D binding sites in the Rhesus monkey brain using [carbonyl-11C]zolmitriptan
- 2011
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Ingår i: International Journal of Molecular Imaging. - : Hindawi Publishing Corporation. - 2090-1712 .- 2090-1720.
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Tidskriftsartikel (refereegranskat)abstract
- Zolmitriptan is a serotonin 5-HT1B/1D receptor agonist that is an effective and well-tolerated drug for migraine treatment. In a human positron emission tomography study, [11C]zolmitriptan crossed the blood-brain barrier but no clear pattern of regional uptake was discernable. The objective of this study was to map the binding of [11C]zolmitriptan in Rhesus monkey brain using whole hemisphere in vitro autoradiography with [11C]zolmitriptan as a radioligand. In saturation studies, [11C]zolmitriptan showed specific (90%) binding to a population of high-affinity binding sites (Kd 0.95–5.06 nM). There was regional distribution of binding sites with the highest density in the ventral pallidum, followed by the external globus pallidus, substantia nigra, visual cortex, and nucleus accumbens. In competitive binding studies with 5-HT1 receptor antagonists, [11C]zolmitriptan binding was blocked by selective 5-HT1B and 5-HT1D ligands in all target areas. There was no appreciable change in binding with the addition of a 5-HT1A receptor antagonist.
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| 3. |
- Smits, Anja, et al.
(författare)
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The clinical value of PET with amino acid tracers for gliomas WHO grade II
- 2011
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Ingår i: International Journal of Molecular Imaging. - : Hindawi Limited. - 2090-1712 .- 2090-1720. ; :Article ID 372509
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Tidskriftsartikel (refereegranskat)abstract
- The clinical management of adults with low-grade gliomas (LGGs) remains a challenge. There is no curative treatment, and management of individual patients is a matter of deciding optimal timing as well as right treatment modality. In addition to conventional imaging techniques, positron emission tomography (PET) with amino acid tracers can facilitate diagnostic and therapeutic procedures. In this paper, the clinical applications of PET with amino acid tracers 11C-methyl-L-methionine (MET) and 18F-fluoro-ethyl-L-tyrosine (FET) for patients with LGG are summarized. We also discuss the value of PET for the long-term followup of this patient group. Monitoring metabolic activity by PET in individual patients during course of disease will provide insight in the biological behavior and evolution of these tumors. As such, spatial changes in tumor activity over time, including shifts of hot-spot regions within the tumor, may reflect intratumoral heterogeneity and correlate to clinical parameters.
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| 4. |
- Naze, Cedric, et al.
(författare)
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Isotope Shifts in Beryllium-, Boron-, Carbon-, and Nitrogen-like Ions from Relativistic Configuration Interaction Calculations
- 2014
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Ingår i: Atomic Data and Nuclear Data Tables. - : Elsevier. - 0092-640X .- 1090-2090. ; 100:5, s. 1197-1249
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Tidskriftsartikel (refereegranskat)abstract
- Energy levels, normal and specific mass shift parameters as well as electronic densities at the nucleus are reported for numerous states along the beryllium, boron, carbon, and nitrogen isoelectronic sequences. Combined with nuclear data, these electronic parameters can be used to determine values of level and transition isotope shifts. The calculation of the electronic parameters is done using first-order perturbation theory with relativistic configuration interaction wavefunctions that account for valence, core–valence, and core–core correlation effects as zero-order functions. Results are compared with experimental and other theoretical values, when available.
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