| 1. |
- Fei, Yiqiu, et al.
(författare)
-
The Role of Dihydroresveratrol in Enhancing the Synergistic Effect of Ligilactobacillus salivarius Li01 and Resveratrol in Ameliorating Colitis in Mice
- 2022
-
Ingår i: Research. - : American Association for the Advancement of Science (AAAS). - 2096-5168 .- 2639-5274. ; 2022
-
Tidskriftsartikel (refereegranskat)abstract
- Currently approved therapeutical strategies for inflammatory bowel diseases (IBD) suffer from variable efficacy and association with risk of serious side effects. Therefore, efforts have been made in searching for alternative therapeutics strategies utilizing gut microbiota manipulation. In this study, we show that the probiotic strain Ligilactobacillus salivarius Li01 (Li01) and the phytochemical prebiotic resveratrol (RSV) have synergistic effect in ameliorating colitis in mice. Oral coadministration of Li01 (10(9) CFU/d) and RSV (1.5 g/kg/d) promoted restoration of various inflammatory injuries and gut microbiota composition, exhibiting a favorable anti-inflammatory effect in DSS-induced colitis mice. The combination treatment was associated with reductions in the levels of proinflammatory cytokines IL-1 beta and IL-6 and increases in the levels of the anti-inflammatory cytokine IL-17A in mouse serum. Moreover, the combination treatment was found to alter the composition and metabolism of the gut microbiota, especially influencing the production of short chain fatty acids and anti-inflammatory related molecules. The mechanism underlying the improved anti-inflammatory effect from the RSV and Li01 combination treatment was found to be associated with the environmental sensor mammalian aryl hydrocarbon receptor (AHR) and tryptophan metabolism pathway. Administration of RSV in combination with Li01 in different mouse model led to enhanced conversion of RSV into metabolites, including dihydroresveratrol (DHR), resveratrol-sulfate, and resveratrol-glucuronide. DHR was found to be the dominant metabolite of RSV in conventional and colitis mice. An increased DHR/RSV ratio was confirmed to activate AHR and contribute to an enhanced anti-inflammatory effect. DHR is considered as a potential AHR ligand. The DHR/RSV ratio also affected the serotonin pathway by controlling the expression of Tph1, SERT, and 5-HT7R leading to amelioration of colitis in mice. Our data suggest that treatment with a combination of Li01 and RSV has potential as a therapeutic strategy for IBD; further investigation of this combination in clinical settings is warranted.
|
|
| 2. |
- Li, June, et al.
(författare)
-
Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression
- 2023
-
Ingår i: Research. - 2096-5168. ; 6
-
Tidskriftsartikel (refereegranskat)abstract
- Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. However, the anti-inflammatory/immunosuppressive potential of platelets has been poorly explored. Here, we uncovered, unexpectedly, desialylated platelets (dPLTs) down-regulated immune responses against both platelet-associated and -independent antigen challenges. Utilizing multispectral photoacoustic tomography, we tracked dPLT trafficking to gut vasculature and an exclusive Kupffer cell-mediated dPLT clearance in the liver, a process that we identified to be synergistically dependent on platelet glycoprotein Ibα and hepatic Ashwell-Morell receptor. Mechanistically, Kupffer cell clearance of dPLT potentiated a systemic immunosuppressive state with increased anti-inflammatory cytokines and circulating CD4+ regulatory T cells, abolishable by Kupffer cell depletion. Last, in a clinically relevant model of hemophilia A, presensitization with dPLT attenuated anti-factor VIII antibody production after factor VIII ( infusion. As platelet desialylation commonly occurs in daily-aged and activated platelets, these findings open new avenues toward understanding immune homeostasis and potentiate the therapeutic potential of dPLT and engineered dPLT transfusions in controlling autoimmune and alloimmune diseases.
|
|
| 3. |
- Lv, Zhihan, Dr. 1984-
(författare)
-
Digital Twins in Industry 5.0
- 2023
-
Ingår i: RESEARCH. - : American Association for the Advancement of Science (AAAS). - 2096-5168 .- 2639-5274. ; 6
-
Forskningsöversikt (refereegranskat)abstract
- This work aims to explore the impact of Digital Twins Technology on industrial manufacturing in the context of Industry 5.0. A computer is used to search the Web of Science database to summarize the Digital Twins in Industry 5.0. First, the background and system architecture of Industry 5.0 are introduced. Then, the potential applications and key modeling technologies in Industry 5.0 are discussd. It is found that equipment is the infrastructure of industrial scenarios, and the embedded intelligent upgrade for equipment is a Digital Twins primary condition. At the same time, Digital Twins can provide automated real-time process analysis between connected machines and data sources, speeding up error detection and correction. In addition, Digital Twins can bring obvious efficiency improvements and cost reductions to industrial manufacturing. Digital Twins reflects its potential application value and subsequent potential value in Industry 5.0 through the prospect. It is hoped that this relatively systematic overview can provide technical reference for the intelligent development of industrial manufacturing and the improvement of the efficiency of the entire business process in the Industrial X.0 era.
|
|
| 4. |
- Wang, Xuran, et al.
(författare)
-
De Novo Design of Spiro-Type Hole-Transporting Material: Anisotropic Regulation Toward Efficient and Stable Perovskite Solar Cells
- 2024
-
Ingår i: RESEARCH. - : AMER ASSOC ADVANCEMENT SCIENCE. - 2096-5168. ; 7
-
Tidskriftsartikel (refereegranskat)abstract
- 2,2′,7,7′-Tetrakis(N,N-di-p-methoxyphenyl)-amine-9,9′-spirobifluorene (Spiro-OMeTAD) represents the state-of-the-art hole-transporting material (HTM) in n-i-p perovskite solar cells (PSCs). However, its susceptibility to stability issues has been a long-standing concern. In this study, we embark on a comprehensive exploration of the untapped potential within the family of spiro-type HTMs using an innovative anisotropic regulation strategy. Diverging from conventional approaches that can only modify spirobifluorene with single functional group, this approach allows us to independently tailor the two orthogonal components of the spiro-skeleton at the molecular level. The newly designed HTM, SF-MPA-MCz, features enhanced thermal stability, precise energy level alignment, superior film morphology, and optimized interfacial properties when compared to Spiro-OMeTAD, which contribute to a remarkable power conversion efficiency (PCE) of 24.53% for PSCs employing SF-MPA-MCz with substantially improved thermal stability and operational stability. Note that the optimal concentration for SF-MPA-MCz solution is only 30 mg/ml, significantly lower than Spiro-OMeTAD (>70 mg/ml), which could remarkably reduce the cost especially for large-area processing in future commercialization. This work presents a promising avenue for the versatile design of multifunctional HTMs, offering a blueprint for achieving efficient and stable PSCs.
|
|
