| 1. |
- Akpe, Victor, et al.
(författare)
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Understanding the Photochemical Pathway of In Vitro Target Delivery of Aluminium Phthalocyanine : A Mechanistic Approach Using Radical Reaction Chemistry
- 2014
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Ingår i: ChemPlusChem. - : Wiley. - 2192-6506. ; 79:5, s. 671-679
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Tidskriftsartikel (refereegranskat)abstract
- A classical dye, aluminium phthalocyanine (AlPc), is used to study the photochemical processes involved in the chromophore-assisted laser inactivation technique. Both cell-free and cell-based systems are investigated by novel methods and radical reaction chemistry. Findings on the photochemical pathways in two models representing cell-free and a cell-based systems are reported. In the cell-free system, the unsubstituted, free, fluorescence-active photosensitiser AlPc recovers its fluorescence signal by means of phosphorescence through a reversible photobleaching process. In the cell-based system, photoactivation of substituted AlPc conjugated to an antibody results in the loss of fluorescence signal at the area examined. Reinjection of the AlPc-conjugated antibodies restores the fluorescence signal.
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| 2. |
- Alsaoub, Sabine, et al.
(författare)
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An Intrinsic Self-Charging Biosupercapacitor Comprised of a High-Potential Bioanode and a Low-Potential Biocathode
- 2017
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Ingår i: ChemPlusChem. - : John Wiley & Sons. - 2192-6506. ; 82:4, s. 576-583
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Tidskriftsartikel (refereegranskat)abstract
- An intrinsic self-charging biosupercapacitor built on a unique concept for the fabrication of biodevices based on redox polymers is presented. The biosupercapacitor consists of a high-potential redox polymer based bioanode and a low-potential redox polymer based biocathode in which the potentials of the electrodes in the discharged state show an apparent potential mismatch E-anode > E-cathode and prevent the use of the device as a conventional biofuel cell. Upon charging, the potentials of the electrodes are shifted to more positive (cathode) and more negative (anode) values because of a change in the a(ox-)to-a(red) ratio within the redox polymer matrix. Hence, a potential inversion occurs in the charged state (E-anode < E-cathode) and an open circuit voltage of >0.4 V is achieved and the bio-device acts as a true biosupercapacitor. The bioanode consists of a novel specifically designed high-potential Os complex modified polymer for the efficient immobilization and electrical wiring of glucose converting enzymes, such as glucose oxidase and flavin adenine dinucleotide (FAD)-dependent glucose dehydrogenase. The cathodic side is constructed from a low-potential Os complex modified polymer integrating the O-2 reducing enzyme, bilirubin oxidase. The large potential differences between the redox polymers and the prosthetic groups of the biocatalysts ensure fast and efficient charging of the biodevice.
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| 3. |
- Arja, Katriann, et al.
(författare)
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Self-Assembly of Chiro-Optical Materials from Nonchiral Oligothiophene-Porphyrin Derivatives and Random Coil Synthetic Peptides
- 2023
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Ingår i: ChemPlusChem. - : Wiley. - 2192-6506. ; 88:1
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Tidskriftsartikel (refereegranskat)abstract
- Biomimetic chiral optoelectronic materials can be utilized in electronic devices, biosensors and artificial enzymes. Herein, this work reports the chiro-optical properties and architectural arrangement of optoelectronic materials generated from self-assembly of initially nonchiral oligothiophene−porphyrin derivatives and random coil synthetic peptides. The photo-physical- and structural properties of the materials were assessed by absorption-, fluorescence- and circular dichroism spectroscopy, as well as dynamic light scattering, scanning electron microscopy and theoretical calculations. The materials display a three-dimensional ordered helical structure and optical activity that are observed due to an induced chirality of the optoelectronic element upon interaction with the peptide. Both these properties are influenced by the chemical composition of the oligothiophene−porphyrin derivative, as well as the peptide sequence. We foresee that our findings will aid in developing self-assembled optoelectronic materials with dynamic architectonical accuracies, as well as offer the possibility to generate the next generation of materials for a variety of bioelectronic applications.
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| 4. |
- Awad, Doaa, et al.
(författare)
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Halogenated Dodecaborate Clusters as Agents to Trigger Release of Liposomal Contents
- 2015
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Ingår i: ChemPlusChem. - : Wiley. - 2192-6506. ; 80:4, s. 656-664
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Tidskriftsartikel (refereegranskat)abstract
- Halogenated dodecaborates, and especially dodecaiodododecaborate(2−), are found to trigger effectively the release of the contents of phospholipid liposomes, including liposomes containing distearoylphosphatidylcholine and cholesterol, which are used clinically in cancer therapy. The basis of the release is studied through differential scanning calorimetry, cryo-transmission electron microscopy, and atomic force microscopy. Upon administration at high concentrations, drastic morphological changes are induced by the dodecaborates. Their possible use in triggered release is suggested.
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| 5. |
- Berniak, Tomasz, et al.
(författare)
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Covalent bonding of N-hydroxyphthalimide on mesoporous silica for catalytic aerobic oxidation of p-xylene at atmospheric pressure
- 2024
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Ingår i: ChemPlusChem. - 2192-6506.
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Tidskriftsartikel (refereegranskat)abstract
- The surface of SBA-15 mesoporous silica was modified by N-hydroxyphthalimide (NHPI) moieties acting as immobilized active species for aerobic oxidation of alkylaromatic hydrocarbons. The incorporation was carried out by four original approaches: the grafting-from and grafting-onto techniques, using the presence of surface silanols enabling the formation of particularly stable O-Si-C bonds between the silica support and the organic modifier. The strategies involving the Heck coupling led to the formation of NHPI groups separated from the SiO2 surface by a vinyl linker, while one of the developed modification paths based on the grafting of an appropriate organosilane coupling agent resulted in the active phase devoid of this structural element. The successful course of the synthesis was verified by FTIR and H-1 NMR measurements. Furthermore, the formed materials were examined in terms of their chemical composition (elemental analysis, thermal analysis), structure of surface groups (C-13 NMR, XPS), porosity (low-temperature N-2 adsorption), and tested as catalysts in the aerobic oxidation of p-xylene at atmospheric pressure. The highest conversion and selectivity to p-toluic acid were achieved using the catalyst with enhanced availability of non-hydrolyzed NHPI groups in the pore system. The catalytic stability of the material was additionally confirmed in several subsequent reaction cycles.
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| 6. |
- Brudvig, G. W., et al.
(författare)
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Catalytic Systems for Water Splitting
- 2016
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Ingår i: ChemPlusChem. - : Wiley-VCH Verlagsgesellschaft. - 2192-6506. ; 81:10, s. 1017-1019
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Tidskriftsartikel (refereegranskat)
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| 7. |
- Denk, C., et al.
(författare)
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Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio-Crosslinking
- 2019
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Ingår i: ChemPlusChem. - : Wiley. - 2192-6506. ; 84:7, s. 775-778
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Tidskriftsartikel (refereegranskat)abstract
- In the past decade, several developments have expanded the chemical toolbox for astatination and the preparation of 211 At-labeled radiopharmaceuticals. However, there is still a need for advanced methods for the synthesis of astatinated (bio)molecules to address challenges such as limited in vivo stability. Herein, we report the development of multifunctional 211 At-labeled reagents that can be prepared by applying a modular and versatile click approach for rapid assembly. The introduction of tetrazines as bioorthogonal tags enables rapid radiolabeling and radio-crosslinking, which is demonstrated by steric shielding of 211 At to significantly increase label stability in human blood plasma. © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
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| 8. |
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| 9. |
- Durbeej, Bo, 1973-, et al.
(författare)
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Molecular Photoswitching Aided by Excited-State Aromaticity
- 2018
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Ingår i: ChemPlusChem. - Weinheim, Germany : Wiley-VCH Verlagsgesellschaft. - 2192-6506. ; 83:11, s. 958-967
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Tidskriftsartikel (refereegranskat)abstract
- Central to the development of optoelectronic devices is the availability of efficient synthetic molecular photoswitches, the design of which is an arena where the evolving concept of excited‐state aromaticity (ESA) is yet to make a big impact. The aim of this minireview is to illustrate the potential of this concept to become a key tool for the future design of photoswitches. The paper starts with a discussion of challenges facing the use of photoswitches for applications and continues with an account of how the ESA concept has progressed since its inception. Then, following some brief remarks on computational modeling of photoswitches and ESA, the paper describes two different approaches to improve the quantum yields and response times of switches driven by E/Z photoisomerization or photoinduced H‐atom/proton transfer reactions through simple ESA considerations. It is our hope that these approaches, verified by quantum chemical calculations and molecular dynamics simulations, will help stimulate the application of the ESA concept as a general tool for designing more efficient photoswitches and other functional molecules used in optoelectronic devices.
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| 10. |
- Erdélyi, Máté, 1975-, et al.
(författare)
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Halogen Bonding : From Fundamentals to Applications
- 2021
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Ingår i: ChemPlusChem. - : John Wiley & Sons. - 2192-6506. ; 86:9, s. 1229-1230
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Guest Editors Maté Erdélyi, Catharine Esterhuysen, and Weilang Zhu introduce the joint Special Collection on Halogen Bonding published by ChemPlusChem and The Chemical Record. This collection is organized in association with the 4th International Symposium on Halogen Bonding (ISXB4) and features top multidisciplinary contributions where halogen bonding plays a pivotal role, including computational, synthetic and catalytic, supramolecular and crystal engineering, and biological investigations and applications.
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