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- Wagner, Darcy E.
(författare)
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Bioengineering Approaches for the Distal Lung
- 2021
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Ingår i: Encyclopedia of Respiratory Medicine, Second Edition. - 9780081027240 - 9780081027233 ; 1, s. 788-795
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Bokkapitel (refereegranskat)abstract
- Chronic and acute lung diseases are the third and fourth leading causes of global mortality. Distal lung tissue is severely damaged in many lung diseases, causing respiratory insufficiency from loss of surface area available for gas exchange. Current therapies aim at relieving symptoms and are unable to reverse disease. Lung transplantation remains the only potential curative option at end-stage disease but is severely limited by a lack of suitable donor lungs and low long-term survival. Bioengineering lung tissue or bioengineering cells with biomaterials for transplantation is an exciting new approach to (re)generate tissue to close this large unmet clinical need.
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