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- Klementieva, O., et al.
(författare)
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Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice
- 2018
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Ingår i: 2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018. - 9781538638095 ; 2018-September
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Konferensbidrag (refereegranskat)abstract
- Aβ is a class of aggregation-prone proteins, which may misfold into stable, β-sheet rich fibrils. Aβ is linked to the development of synaptic pathology in Alzheimer's disease (AD). However, a main question in the AD field is how Aβ contributes to AD neuropathology? Up to now there is little evidence for protein structural changes in diseased neuron. Our aim is to study the distribution of β-sheet structures in AD transgenic neurons in order to uncover sub-cellular mechanism(s) by which amyloid β-sheet structures are involved in AD pathology.
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