| 1. |
- Toprak, Muhammet S., et al.
(författare)
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Active Cooperative Assemblies Towards Nanocomposites
- 2009
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Ingår i: ADVANCES IN MATERIAL DESIGN FOR REGENERATIVE MEDICINE, DRUG DELIVERY AND TARGETING/IMAGING. - 9781605111124 ; , s. 197-202
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Konferensbidrag (refereegranskat)abstract
- This work reports on the fabrication of novel type of assemblies bearing magnetic nanoparticles and inorganic shells prepared via a biomimetic route of complex coacervation. Magnetic nanoparticles fabricated under controlled conditions were surface modified with polyacrylic acid (PAA). Subsequently, PAA spontaneously formed spherical assemblies in contact with certain ions, such as Ca2+. The stability of these microspheres against environmental alterations such as pH, ionic strength, and dilution was increased through cross-linking. Ethylene diammine (EDA) was used as a cross-linker, which resulted in mechanically stabilized system that does not show sensitivity towards the external pH values. Important parameters for the formation of these coacervates as well as mechanism of formation and cross-linking have been evaluated by FTIR analysis. The cooperative assemblies are still active for further reaction and were used for the growth of an inorganic aluminum oxide shell. SEM analysis of these spheres showed that the structures are hollow with a large interior volume. A biocompatible outer surface combined with the magnetic functionality is very important for the targeted drug delivery devices for biomedical applications.
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| 2. |
- Vogt, Carmen M., et al.
(författare)
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Optimised synthetic route for tuneable shell Si02@Fe304 core-shell nanoparticles
- 2009
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Ingår i: Advances in material design for regenerative medicine, drug delivery, and targeting/imaging. - : Materials Research Society. - 9781605111124 ; , s. 209-214
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Konferensbidrag (refereegranskat)abstract
- Multifunctional nanoparticles (that have in their structure different components that can perform various functions) are subject of intensive research activities as they find a large variety of applications in numerous biomedical fields from enhancement of image contrast in MRI to different magnetically controllable drug delivery systems. In this study we report on the synthesis of well-separated, monodisperse single core-shell Si02@Fe304 nanoparticles with an overall diameter of ̃30 nm. The influence of stirring rate and reaction time on synthesis of tuneable shell thickness core-shell nanoparticles is reported. Particles' cell toxicity and performance as MRI contrast agents were also studied due to their promising biological applications (as contrast agents, cell labelling and separation, drug delivery systems, etc.) and results are promising in terms of MRI performance as well as having no significant cytotoxicity.
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