| 1. |
- Moiseenko, V. E., et al.
(författare)
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Stellator research at IPP KIPT : Status and prospects
- 2019
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Ingår i: PROBLEMS OF ATOMIC SCIENCE AND TECHNOLOGY. - : KHARKOV INST PHYSICS & TECHNOLOGY. - 1562-6016. ; :1, s. 3-8
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Tidskriftsartikel (refereegranskat)abstract
- Features of the recent Uragan-2M campaign are reviewed together with some theoretical advances. They include experiments with B4C limiter, studies of various 1. . . 20 kHz oscillations, development of a new in-situ diagnostics for wall conditions, i.e. the thermal desorption probe, the improved numerical model of RF plasma production in stellarators in the ion cyclotron and electron-cyclotron frequency ranges, a new positive-definite form of time-harmonic Maxwell's equations and plasma start-up studies.
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| 2. |
- Thiele, I., et al.
(författare)
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A community-driven global reconstruction of human metabolism
- 2013
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Ingår i: Nature Biotechnology. - : Springer Science and Business Media LLC. - 1087-0156 .- 1546-1696. ; 31:5, s. 419-
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Tidskriftsartikel (refereegranskat)abstract
- Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven, consensus 'metabolic reconstruction', which is the most comprehensive representation of human metabolism that is applicable to computational modeling. Compared with its predecessors, the reconstruction has improved topological and functional features, including similar to 2x more reactions and similar to 1.7x more unique metabolites. Using Recon 2 we predicted changes in metabolite biomarkers for 49 inborn errors of metabolism with 77% accuracy when compared to experimental data. Mapping metabolomic data and drug information onto Recon 2 demonstrates its potential for integrating and analyzing diverse data types. Using protein expression data, we automatically generated a compendium of 65 cell type-specific models, providing a basis for manual curation or investigation of cell-specific metabolic properties. Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/.
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| 3. |
- Moiseyenko, Volodymyr, et al.
(författare)
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Developments for stellarator-mirror fusion-fission hybrid concept
- 2021
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Ingår i: Problems of Atomic Science and Technology, Ser. Thermonuclear Fusion. - : NRC Kurchatov Institute. - 0202-3822. ; 44:2, s. 111-117
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Tidskriftsartikel (refereegranskat)abstract
- Conceptual development activities on a stellarator-mirror-based fission-fusion hybrid system (SM hybrid) are reviewed. Intended fortransmutation of spent nuclear fuel and safe fission energy production, SM hybrid consists of a fusion neutron source and a powerful subcritical fast fission reactor core. Its fusion component is a stellarator with an embedded magnetic mirror. The stellarator allows for theconfinement of a moderately hot (1—2 keV) deuterium plasma. In the magnetic mirror, the hot sloshing tritium ions are trapped andfusion neutrons are generated. The magnetic mirror is surrounded by a fission mantle, where transmutation of minor actinides and energygeneration take place. One candidate magnetic confinement device for the SM hybrid is the advanced DRACON magnetic trap system,which, unlike the «classical» DRACON version, has one short, rather than two longer mirrors with a relatively short size of 3—6 m. Acomparative numerical analysis of collisionless losses occurring in the magnetic trap part of the single-mirror DRACON leads to a conclusion about the possibility for high-energy tritium ions to be fairly well confined in the magnetic trap area. The Uragan-2M (U-2M)stellarator is used to test the SM hybrid concept with experiment. To fit a magnetic trap into U-2M system, one of the toroidal coils hadto be switched off. A radial escape of charged particles may spontaneously give rise to a weak radial electric field, which may result inclosing the particles’ drift trajectories and thereby substantially improve their confinement. Background plasma confinement withoutdestructive instabilities is demonstrated in the stellarator-mirror regime of U-2M) operation. The sloshing ions driven by radio-frequencyheating are detected in the mirror part of the device with NPA diagnostics. A novel fission mantle design for the SM hybrid is proposed.
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| 4. |
- Aidas, Kestutis, et al.
(författare)
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The Dalton quantum chemistry program system
- 2014
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Ingår i: WIREs Computational Molecular Science. - : Wiley. - 1759-0876 .- 1759-0884. ; 4:3, s. 269-284
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Tidskriftsartikel (refereegranskat)abstract
- Dalton is a powerful general-purpose program system for the study of molecular electronic structure at the Hartree-Fock, Kohn-Sham, multiconfigurational self-consistent-field, MOller-Plesset, configuration-interaction, and coupled-cluster levels of theory. Apart from the total energy, a wide variety of molecular properties may be calculated using these electronic-structure models. Molecular gradients and Hessians are available for geometry optimizations, molecular dynamics, and vibrational studies, whereas magnetic resonance and optical activity can be studied in a gauge-origin-invariant manner. Frequency-dependent molecular properties can be calculated using linear, quadratic, and cubic response theory. A large number of singlet and triplet perturbation operators are available for the study of one-, two-, and three-photon processes. Environmental effects may be included using various dielectric-medium and quantum-mechanics/molecular-mechanics models. Large molecules may be studied using linear-scaling and massively parallel algorithms. Dalton is distributed at no cost from for a number of UNIX platforms.
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| 5. |
- Berntorp, E., et al.
(författare)
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Fifth Åland Island conference on von Willebrand disease
- 2018
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Ingår i: Haemophilia. - : Wiley. - 1351-8216. ; 2424 Suppl 4, s. 5-19
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Tidskriftsartikel (refereegranskat)abstract
- The fifth Åland Island meeting on von Willebrand disease (VWD) was held on the Åland Islands, Finland, from 22 to 24 September 2016—90 years after the first case of VWD was diagnosed in a patient from the Åland Islands in 1926. This meeting brought together experts in the field of VWD to share knowledge and expertise on current trends and challenges in VWD. Topics included the storage and release of von Willebrand factor (VWF), epidemiology and diagnostics in VWD, treatment of VWD, angiogenesis and VWF inhibitors.
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| 6. |
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| 7. |
- Gruber, T, et al.
(författare)
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Geodetic SAR for Height System Unification and Sea Level Research - Observation Concept and Results in the Baltic Sea
- 2021
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Konferensbidrag (refereegranskat)abstract
- Traditionally, sea level is observed at tide gauge stations, which usually also serve as height reference stations for national leveling networks and therefore define a height system of a country. Thus, sea level research across countries is closely linked to height system unification and needs to be regarded jointly. One of the main deficiencies to use tide gauge data for geodetic sea level research and height systems unification is that only a few stations are connected to permanent GNSS receivers next to the tide gauge in order to systematically observe vertical land motion. As a new observation technique, absolute positioning by SAR using active transponders on ground can fill this gap by systematically observing time series of geometric heights at tide gauge stations. By additionally knowing the tide gauge geoid heights in a global height reference frame, one can finally obtain absolute sea level heights at each tide gauge. With this information the impact of climate change on the sea level can be quantified in an absolute manner and height systems can be connected across the oceans. First results from applying this technique at selected tide gauges at the Baltic coasts are promising but also exhibit some problems related to the new technique. The paper presents the concept of using the new observation type in an integrated sea level observing system and provides results for a test network in the Baltic sea area by combining geometric and physical heights with tide gauge readings.
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| 8. |
- Gusev, Alexey N., et al.
(författare)
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Schiff Base Zinc(II) Complexes as Promising Emitters for Blue Organic Light-Emitting Diodes
- 2021
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Ingår i: ACS Applied Electronic Materials. - : American Chemical Society (ACS). - 2637-6113. ; 3:8, s. 3436-3444
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Tidskriftsartikel (refereegranskat)abstract
- Organometallic blue fluorescent Zn(II) Schiff base complexes are synthesized and explored computationally in order to use them in organic electroluminescent heterostructures. Characterization of these pyrazolone-based azomethine-zinc complexes was accomplished by various physicochemical techniques to get insight into their applicability as an active layer in light-emitting diodes. All the complexes demonstrate high thermal stability and remarkable photoluminescence both in solution and in the solid state with maximum in the blue region. Quantum chemical calculations of the first exited electronic state and vertical singlet-singlet electronic transitions by means of time-dependent density functional theory calculations and results show that the origin of the luminescence for the target complexes refers to the intraligand charge transfer within the Schiff bases. The constructed light-emitting diodes demonstrate low input voltage (3.2-4.0 V), brightness at a level of 4300-11,600 Cd m(-2), and external quantum efficiency of up to 3.2%, which is a good value for purely fluorescent organic light-emitting diodes.
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| 9. |
- Jonkman, Nini H., et al.
(författare)
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Do self-management interventions work in patients with heart failure? An individual patient data meta-analysis
- 2016
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Ingår i: Circulation. - : Lippincott Williams & Wilkins. - 0009-7322 .- 1524-4539. ; 133:12, s. 1189-1198
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: -Self-management interventions are widely implemented in care for patients with heart failure (HF). Trials however show inconsistent results and whether specific patient groups respond differently is unknown. This individual patient data meta-analysis assessed the effectiveness of self-management interventions in HF patients and whether subgroups of patients respond differently.METHODS AND RESULTS: -Systematic literature search identified randomized trials of self-management interventions. Data of twenty studies, representing 5624 patients, were included and analyzed using mixed effects models and Cox proportional-hazard models including interaction terms. Self-management interventions reduced risk of time to the combined endpoint HF-related hospitalization or all-cause death (hazard ratio [HR], 0.80; 95% confidence interval [CI], 0.71-0.89), time to HF-related hospitalization (HR, 0.80; 95%CI, 0.69-0.92), and improved 12-month HF-related quality of life (standardized mean difference 0.15; 95%CI, 0.00-0.30). Subgroup analysis revealed a protective effect of self-management on number of HF-related hospital days in patients <65 years (mean number of days 0.70 days vs. 5.35 days; interaction p=0.03). Patients without depression did not show an effect of self-management on survival (HR for all-cause mortality, 0.86; 95%CI, 0.69-1.06), while in patients with moderate/severe depression self-management reduced survival (HR, 1.39; 95%CI, 1.06-1.83, interaction p=0.01).CONCLUSIONS: -This study shows that self-management interventions had a beneficial effect on time to HF-related hospitalization or all-cause death, HF-related hospitalization alone, and elicited a small increase in HF-related quality of life. The findings do not endorse limiting self-management interventions to subgroups of HF patients, but increased mortality in depressed patients warrants caution in applying self-management strategies in these patients.
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| 10. |
- Jonkman, Nini H., et al.
(författare)
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What Are Effective Program Characteristics of Self-Management Interventions in Patients With Heart Failure? : An Individual Patient Data Meta-analysis
- 2016
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Ingår i: Journal of Cardiac Failure. - : Elsevier BV. - 1071-9164 .- 1532-8414. ; 22:11, s. 861-871
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Tidskriftsartikel (refereegranskat)abstract
- Background To identify those characteristics of self-management interventions in patients with heart failure (HF) that are effective in influencing health-related quality of life, mortality, and hospitalizations.Methods and Results Randomized trials on self-management interventions conducted between January 1985 and June 2013 were identified and individual patient data were requested for meta-analysis. Generalized mixed effects models and Cox proportional hazard models including frailty terms were used to assess the relation between characteristics of interventions and health-related outcomes. Twenty randomized trials (5624 patients) were included. Longer intervention duration reduced mortality risk (hazard ratio 0.99, 95% confidence interval [CI] 0.97–0.999 per month increase in duration), risk of HF-related hospitalization (hazard ratio 0.98, 95% CI 0.96–0.99), and HF-related hospitalization at 6 months (risk ratio 0.96, 95% CI 0.92–0.995). Although results were not consistent across outcomes, interventions comprising standardized training of interventionists, peer contact, log keeping, or goal-setting skills appeared less effective than interventions without these characteristics.Conclusion No specific program characteristics were consistently associated with better effects of self-management interventions, but longer duration seemed to improve the effect of self-management interventions on several outcomes. Future research using factorial trial designs and process evaluations is needed to understand the working mechanism of specific program characteristics of self-management interventions in HF patients.
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