| 1. |
- Zheng, Hou-Feng, et al.
(författare)
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Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 526:7571, s. 112-
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Tidskriftsartikel (refereegranskat)abstract
- The extent to which low-frequency (minor allele frequency (MAF) between 1-5%) and rare (MAF <= 1%) variants contribute to complex traits and disease in the general population is mainly unknown. Bone mineral density (BMD) is highly heritable, a major predictor of osteoporotic fractures, and has been previously associated with common genetic variants(1-8), as well as rare, population specific, coding variants(9). Here we identify novel non-coding genetic variants with large effects on BMD (n(total) = 53,236) and fracture (n(total) = 508,253) in individuals of European ancestry from the general population. Associations for BMD were derived from whole-genome sequencing (n = 2,882 from UK10K (ref. 10); a population-based genome sequencing consortium), whole-exome sequencing (n = 3,549), deep imputation of genotyped samples using a combined UK10K/1000 Genomes reference panel (n = 26,534), and de novo replication genotyping (n = 20,271). We identified a low-frequency non-coding variant near a novel locus, EN1, with an effect size fourfold larger than the mean of previously reported common variants for lumbar spine BMD8 (rs11692564(T), MAF51.6%, replication effect size510.20 s.d., P-meta = 2 x 10(-14)), which was also associated with a decreased risk of fracture (odds ratio = 0.85; P = 2 x 10(-11); ncases = 98,742 and ncontrols = 409,511). Using an En1cre/flox mouse model, we observed that conditional loss of En1 results in low bone mass, probably as a consequence of high bone turnover. We also identified a novel low frequency non-coding variant with large effects on BMD near WNT16 (rs148771817(T), MAF = 1.2%, replication effect size +10.41 s.d., P-meta = 1 x 10(-11)). In general, there was an excess of association signals arising from deleterious coding and conserved non-coding variants. These findings provide evidence that low-frequency non-coding variants have large effects on BMD and fracture, thereby providing rationale for whole-genome sequencing and improved imputation reference panels to study the genetic architecture of complex traits and disease in the general population.
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| 2. |
- Aad, G., et al.
(författare)
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Identification and energy calibration of hadronically decaying tau leptons with the ATLAS experiment in pp collisions at root s=8 TeV
- 2015
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 75:7
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes the trigger and offline reconstruction, identification and energy calibration algorithms for hadronic decays of tau leptons employed for the data collected from pp collisions in 2012 with the ATLAS detector at the LHC center-of-mass energy root s = 8 TeV. The performance of these algorithms is measured in most cases with Z decays to tau leptons using the full 2012 dataset, corresponding to an integrated luminosity of 20.3 fb(-1). An uncertainty on the offline reconstructed tau energy scale of 2-4%, depending on transverse energy and pseudorapidity, is achieved using two independent methods. The offline tau identification efficiency is measured with a precision of 2.5% for hadronically decaying tau leptons with one associated track, and of 4% for the case of three associated tracks, inclusive in pseudorapidity and for a visible transverse energy greater than 20 GeV. For hadronic tau lepton decays selected by offline algorithms, the tau trigger identification efficiency is measured with a precision of 2-8%, depending on the transverse energy. The performance of the tau algorithms, both offline and at the trigger level, is found to be stable with respect to the number of concurrent proton-proton interactions and has supported a variety of physics results using hadronically decaying tau leptons at ATLAS.
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| 3. |
- Abulaiti, Yiming, et al.
(författare)
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Centrality, rapidity, and transverse momentum dependence of isolated prompt photon production in lead-lead collisions at root S-NN=2.76 TeV measured with the ATLAS detector
- 2016
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Ingår i: Physical Review C. - : American Physical Society. - 2469-9985. ; 93:3
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Tidskriftsartikel (refereegranskat)abstract
- Prompt photon production in root S-NN = 2.76-TeV Pb + Pb collisions has been measured by the ATLAS experiment at the Large Hadron Collider using data collected in 2011 with an integrated luminosity of 0.14 nb(-1). Inclusive photon yields, scaled by the mean nuclear thickness function, are presented as a function of collision centrality and transverse momentum in two pseudorapidity intervals, vertical bar eta vertical bar < 1.37 and 1.52 <= vertical bar eta vertical bar < 2.37. The scaled yields in the two pseudorapidity intervals, as well as the ratios of the forward yields to those at midrapidity, are compared to the expectations from next-to-leading-order perturbative QCD (pQCD) calculations. The measured cross sections agree well with the predictions for proton-proton collisions within statistical and systematic uncertainties. Both the yields and the ratios are also compared to two other pQCD calculations, one which uses the isospin content appropriate to colliding lead nuclei and another which includes nuclear modifications to the nucleon parton distribution functions.
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| 4. |
- Abulaiti, Yiming, et al.
(författare)
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Measurement of the centrality dependence of the charged-particle pseudorapidity distribution in proton-lead collisions at root s(NN)=5.02 TeV with the ATLAS detector
- 2016
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 76:4
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Tidskriftsartikel (refereegranskat)abstract
- The centrality dependence of the mean charged-particle multiplicity as a function of pseudorapidity is measured in approximately 1 mu b(-1) of proton-lead collisions at a nucleon-nucleon centre-of-mass energy of root s(NN) = 5.02 TeV using the ATLAS detector at the Large Hadron Collider. Charged particles with absolute pseudorapidity less than 2.7 are reconstructed using the ATLAS pixel detector. The p + Pb collision centrality is characterised by the total transverse energy measured in the Pb-going direction of the forward calorimeter. The charged-particle pseudorapidity distributions are found to vary strongly with centrality, with an increasing asymmetry between the proton-going and Pb-going directions as the collisions become more central. Three different estimations of the number of nucleons participating in the p + Pb collision have been carried out using the Glauber model as well as two Glauber-Gribov inspired extensions to the Glauber model. Charged-particle multiplicities per participant pair are found to vary differently for these three models, highlighting the importance of including colour fluctuations in nucleon-nucleon collisions in the modelling of the initial state of p + Pb collisions.
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| 5. |
- Bertilsson, Filip, et al.
(författare)
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Centralized versus Distributed Nonlinear Model Predictive Control for Online Robot Fleet Trajectory Planning
- 2022
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Ingår i: IEEE International Conference on Automation Science and Engineering. - 2161-8070 .- 2161-8089. ; 2022-August, s. 701-706
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Konferensbidrag (refereegranskat)abstract
- In this paper, we formulate and evaluate a centralized vs. a distributed approach for online trajectory generation for a fleet of mobile robots in the presence of static and dynamic obstacles. Due to dynamic obstacles, the trajectories need to be updated online and this is formulated as a nonlinear model predictive control problem. We show that both centralized and distributed MPC solvers manage to generate smooth collision-free trajectories. The distributed approach is shown to scale to many robots very well. In contrast, the computational cost of the centralized approach increases with the number of robots. However, the trajectories generated by the distributed control approach have larger deviations than those generated by the centralized approach. The experiments suggest that the centralized method should be chosen with sufficient computation resource while the distributed approach is a viable alternative when the number of robots is considerable.
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| 6. |
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| 7. |
- Åkesson, Erik, 1981-
(författare)
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Resultatansvar för likvärdighet : En läroplansteoretisk studie av systematiskt kvalitetsarbete och rektorers sensemaking
- 2024
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this dissertation is to describe and critically analyze ideas about quality management with in different arenas of the Swedish education systemand how these relate to leadership and the enacted curriculum. The study conceptualizes systematic quality work as a governance tool and a national accountability program created with the aim of solving problems concerning lack of equity and lowered national test scores. Two tensions within the policy program are identified. The first is between external results-oriented forms of control and internal professional trust. The second is between national curriculum goals and local organizational goals.The empirical study consists of a cross-case study of the most different designs of four quality systems enacted by the heads of the school organizations and the principals. The main sources of data are interviews with principals and school leaders and documents and policy artifacts. The data are analyzed from a combined perspective of loosely coupled system, discursive institutionalism and sensemaking.The main conclusion of the study is that while systematic quality work represents an attempt by the state to create a more coherent and centralized accountability system, the results point to a decentralized and loosely coupled education system focused on local organizational goals. The contents of the enacted policy solutions show that the ideational content of quality work is highly malleable to localized uses and interpretations, which also raises questions about how equity is to be understood within the policy program.The enacted solutions show great variance concerning how tensions relating to internal and external dimensions of accountability were handled. The reasons for these differences where related to different leadership strategies, varying pressures from the school market and distinct organizational needs. While the enacted accountability systems in all four cases have created results-oriented frameworks for teaching, their impact on the enacted curriculum was clearly mediated in three of the four cases.
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| 8. |
- Aad, G, et al.
(författare)
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Beam-induced and cosmic-ray backgrounds observed in the ATLAS detector during the LHC 2012 proton-proton running period
- 2016
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Ingår i: Journal of Instrumentation. - : IOP PUBLISHING LTD. - 1748-0221. ; 11:5
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Tidskriftsartikel (refereegranskat)abstract
- This paper discusses various observations on beam-induced and cosmic-ray backgrounds in the ATLAS detector during the LHC 2012 proton-proton run. Building on published results based on 2011 data, the correlations between background and residual pressure of the beam vacuum are revisited. Ghost charge evolution over 2012 and its role for backgrounds are evaluated. New methods to monitor ghost charge with beam-gas rates are presented and observations of LHC abort gap population by ghost charge are discussed in detail. Fake jets from colliding bunches and from ghost charge are analysed with improved methods, showing that ghost charge in individual radio-frequency buckets of the LHC can be resolved. Some results of two short periods of dedicated cosmic-ray background data-taking are shown; in particular cosmic-ray muon induced fake jet rates are compared to Monte Carlo simulations and to the fake jet rates from beam background. A thorough analysis of a particular LHC fill, where abnormally high background was observed, is presented. Correlations between backgrounds and beam intensity losses in special fills with very high β∗ are studied. © 2016 CERN for the benefit of the ATLAS collaboration.
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| 9. |
- Aad, G., et al.
(författare)
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Commissioning of the ATLAS Muon Spectrometer with cosmic rays
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 875-916
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Tidskriftsartikel (refereegranskat)abstract
- The ATLAS detector at the Large Hadron Collider has collected several hundred million cosmic ray events during 2008 and 2009. These data were used to commission the Muon Spectrometer and to study the performance of the trigger and tracking chambers, their alignment, the detector control system, the data acquisition and the analysis programs. We present the performance in the relevant parameters that determine the quality of the muon measurement. We discuss the single element efficiency, resolution and noise rates, the calibration method of the detector response and of the alignment system, the track reconstruction efficiency and the momentum measurement. The results show that the detector is close to the design performance and that the Muon Spectrometer is ready to detect muons produced in high energy proton-proton collisions.
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| 10. |
- Aad, G, et al.
(författare)
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Constraints on non-Standard Model Higgs boson interactions in an effective Lagrangian using differential cross sections measured in the H → γγ decay channel at √s=8 TeV with the ATLAS detector
- 2016
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 753, s. 69-85
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Tidskriftsartikel (refereegranskat)abstract
- The strength and tensor structure of the Higgs boson's interactions are investigated using an effective Lagrangian, which introduces additional CP-even and CP-odd interactions that lead to changes in the kinematic properties of the Higgs boson and associated jet spectra with respect to the Standard Model. The parameters of the effective Lagrangian are probed using a fit to five differential cross sections previously measured by the ATLAS experiment in the H→γγ decay channel with an integrated luminosity of 20.3 fb−1 at s=8 TeV. In order to perform a simultaneous fit to the five distributions, the statistical correlations between them are determined by re-analysing the H→γγ candidate events in the proton–proton collision data. No significant deviations from the Standard Model predictions are observed and limits on the effective Lagrangian parameters are derived. The statistical correlations are made publicly available to allow for future analysis of theories with non-Standard Model interactions. © 2015 CERN for the benefit of the ATLAS Collaboration.
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