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| 2. |
- Landström, Anna, 1990, et al.
(författare)
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A life cycle approach to business performance measurement systems
- 2018
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Ingår i: Procedia Manufacturing. - : Elsevier BV. - 2351-9789. ; 25, s. 126-133, s. 126-133
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Konferensbidrag (refereegranskat)abstract
- Virtually every company has implemented a Business Performance Measurement System (BPMS) with the purpose of monitoring production and business performance and to execute the corporate strategy at all levels in a company. The purpose of this article is to shed light on common pitfalls related to the practical use of BPMS and further to present a life cycle model with the purpose of introducing structured approach to avoiding the pitfalls. The article contributes to further development of the BPMS life cycle concept and practical examples of how it can be used.
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| 3. |
- Landström, Anna, 1990, et al.
(författare)
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Present state analysis of BPMS in large manufacturing companies
- 2016
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Ingår i: Proceedings from PMA 2016, 10th conference of the Performance Measurement Association 26-29 June 2016 Edinburgh, Scotland.
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Konferensbidrag (refereegranskat)abstract
- The purpose of this article is to empirically investigate the present state of the performance measurement systems (PMS) at 7 sites of 6 different large Swedish manufacturingcompanies. The methodology has both a bottom-up and a top-down perspective. Important findings are that the PMSs are very similar in how they function but differ a lot in what ismeasured.
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| 4. |
- Sannö, Anna, 1978-, et al.
(författare)
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How to succeed with Co-production : Experiences from industrial researchers
- 2018. - 1
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Rapport (populärvet., debatt m.m.)abstract
- The aim of this handbook is to raise awareness of the differently organised systems when collaborations are to be set up between companies and universities. By presenting experiences from industrial researchers this handbook will be useful for persons that are going to work in a collaborative setting, regardless of whether they come from a company or a university.
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| 5. |
- Zackrisson, Mats, et al.
(författare)
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Sustainability Performance Indicators at Shop Floor Level in Large Manufacturing Companies
- 2017
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Ingår i: The 24th CIRP Conference on Life Cycle Engineering. - : Elsevier. ; 61, s. 457-462
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Konferensbidrag (refereegranskat)abstract
- This article investigates sustainability in the performance measurement systems of Swedish manufacturing companies. It builds on a previous study that documents relatively few direct environmental indicators at shop floor level, which raises questions about possible indirect links between existing indicators and the environment that could be used to improve the environmental aspect of company's sustainability ambitions. A method for identifying and categorizing indirect links to sustainability issues was defined and used. The results suggest that at shop floor level 90% of the indicators have at least an indirect relation to one or more of the sustainability dimensions economy, environment and social, of which 26% are at least indirectly related to the environmental dimension. Despite the many indirect connections, participating companies perceive a need to improve sustainability indicators and some ideas are suggested.
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| 6. |
- Öberg, Fredrik, 1982, et al.
(författare)
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Insight into factors directing high production of eukaryotic membrane proteins; production of 13 human AQPs in Pichia pastoris.
- 2009
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Ingår i: Molecular membrane biology. - : Informa UK Limited. - 1464-5203 .- 0968-7688. ; 26:4, s. 215-27
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Tidskriftsartikel (refereegranskat)abstract
- Membrane proteins are key players in all living cells. To achieve a better understanding of membrane protein function, significant amounts of purified protein are required for functional and structural analyses. Overproduction of eukaryotic membrane proteins, in particular, is thus an essential yet non-trivial task. Hence, improved understanding of factors which direct a high production of eukaryotic membrane proteins is desirable. In this study we have compared the overproduction of all human aquaporins in the eukaryotic host Pichia pastoris. We report quantitated production levels of each homologue and the extent of their membrane localization. Our results show that the protein production levels vary substantially, even between highly homologous aquaporins. A correlation between the extents of membrane insertion with protein function also emerged, with a higher extent of membrane insertion for pure water transporters compared to aquaporin family members with other substrate specificity. Nevertheless, the nucleic acid sequence of the second codon appears to play an important role in overproduction. Constructs containing guanine at the first position of this codon (being part of the mammalian Kozak sequence) are generally produced at a higher level, which is confirmed for hAQP8. In addition, mimicking the yeast consensus sequence (ATGTCT) apparently has a negative influence on the production level, as shown for hAQP1. Moreover, by mutational analysis we show that the yield of hAQP4 can be heavily improved by directing the protein folding pathway as well as stabilizing the aquaporin tetramer.
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| 7. |
- Asklund, Helen, 1975-, et al.
(författare)
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Hur meriterade lärare kan samverka för kollegial pedagogisk utveckling : Exemplet Mata inte studenten
- 2024
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Konferensbidrag (refereegranskat)abstract
- Vad skulle hända om du som lärare slutade att mata studenterna med information om vad och hur de ska lära sig? Den frågan ligger till grund för det kollegiala utvecklingsprojekt som vi, en grupp meriterade och excellenta lärare vid Mittuniversitetet, har genomfört i form av antologin Mata inte studenterna. Med antologiprojektet som utgångspunkt är vårt syfte att dels reflektera över vår kollegiala skrivprocess, dels bidra till den nationella diskussionen om meriterade lärares roll. Vi vill därför lyfta frågor om hur vi gått tillväga, vilka resurser som behövs för att få till stånd ett kollegialt skrivprojekt och eventuella vinster på individuell, kollegial och organisatorisk nivå - alltså de nivåer som är centrala för det akademiska lärarskapet och som meriterade lärare förväntas bidra till att utveckla. Med samtalet riktar vi oss därmed till en bred målgrupp - såväl meriterade lärare som alla med intresse för kollegiala samverkansformer. Rundabordssamtalet inleds med en presentation av vår kollektiva skrivprocess. Boken är resultatet av en idé från ett skrivinternat arrangerat av Nätverket för meriterade lärare på vårt lärosäte. Startpunkten var en diskussion om “spoon-fed students" och hur vi som lärare kan arbeta för ett mer aktivt lärande. Vi beslöt att dela med oss av våra tidigare erfarenheter i ett antologiprojekt. I rundabordssamtalet belyser vi drivkrafter och utmaningar från vår skrivprocess (jmf Fjellström & Wester, 2019) genom att lyfta våra lärdomar. I vidare mening vill vi reflektera över det akademiska lärarskapet och vad som krävs för att det ska fungera. Därefter följer gruppsamtal med erfarenhetsutbyte och diskussion om vilka resurser och strukturer som behövs för pedagogisk utveckling på olika nivåer. Ett sista steg är en kritisk metadiskussion om meriterade lärares roll och den typ av utvecklingsarbete vi bedrivit. Sessionen avslutas med en gemensam summering och dokumenteras i en padlet. Genom samtalet vill vi synliggöra behovet av att gå bortom den egna undervisningspraktiken och möjliggöra ett aktivt kollegialt kunskapsutbyte. Därigenom förstärks i slutändan det akademiska lärarskapet där lärare “kontinuerligt och systematiskt reflekterar över, utforskar och utvecklar den egna pedagogiska praktiken och dess inverkan på studenters lärande” (Bolander Laksov & Scheja, 2020,s.29).Referenser:Bolander Laksov, K., & Scheja, M. (2020). Akademiskt lärarskap. Stockholm: SULF.Fjellström, M. & Wester, M. (2019). Universitetslärares skrivande om och för sin undervisning.Högreutbildning, 9(1), s. 20-33.
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| 8. |
- Dahlin, Anna M, 1979-, et al.
(författare)
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Colorectal cancer prognosis depends on T-cell infiltration and molecular characteristics of the tumor
- 2011
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Ingår i: Modern Pathology. - : Elsevier BV. - 0893-3952 .- 1530-0285. ; 24, s. 671-682
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to relate the density of tumor infiltrating T cells to cancer-specific survival in colorectal cancer, taking into consideration the CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) screening status. The T-cell marker CD3 was stained by immunohistochemistry in 484 archival tumor tissue samples. T-cell density was semiquantitatively estimated and scored 1-4 in the tumor front and center (T cells in stroma), and intraepithelially (T cells infiltrating tumor cell nests). Total CD3 score was calculated as the sum of the three CD3 scores (range 3-12). MSI screening status was assessed by immunohistochemistry. CIMP status was determined by quantitative real-time PCR (MethyLight) using an eight-gene panel. We found that patients whose tumors were highly infiltrated by T cells (total CD3 score ≥7) had longer survival compared with patients with poorly infiltrated tumors (total CD3 score ≤4). This finding was statistically significant in multivariate analyses (multivariate hazard ratio, 0.57; 95% confidence interval, 0.31-1.00). Importantly, the finding was consistent in rectal cancer patients treated with preoperative radiotherapy. Although microsatellite unstable tumor patients are generally considered to have better prognosis, we found no difference in survival between microsatellite unstable and microsatellite stable (MSS) colorectal cancer patients with similar total CD3 scores. Patients with MSS tumors highly infiltrated by T cells had better prognosis compared with intermediately or poorly infiltrated microsatellite unstable tumors (log rank P=0.013). Regarding CIMP status, CIMP-low was associated with particularly poor prognosis in patients with poorly infiltrated tumors (multivariate hazard ratio for CIMP-low versus CIMP-negative, 3.07; 95% confidence interval, 1.53-6.15). However, some subset analyses suffered from low power and are in need of confirmation by independent studies. In conclusion, patients whose tumors are highly infiltrated by T cells have a beneficial prognosis, regardless of MSI, whereas the role of CIMP status in this context is less clear.
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| 9. |
- Dahlin, Anna M, 1979-, et al.
(författare)
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The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status
- 2010
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Ingår i: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 16:6, s. 1845-1855
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: The aim of this study was to relate the CpG island methylator phenotype (CIMP; characterized by extensive promoter hypermethylation) to cancer-specific survival in colorectal cancer, taking into consideration relevant clinicopathologic factors, such as microsatellite instability (MSI) screening status and the BRAF V600E mutation. EXPERIMENTAL DESIGN: Archival tumor samples from 190 patients from the Northern Sweden Health and Disease Study (NSHDS) and 414 patients from the Colorectal Cancer in Umeå Study (CRUMS), including 574 with cancer-specific survival data, were analyzed for an eight-gene CIMP panel using quantitative real-time PCR (MethyLight). MSI screening status was assessed by immunohistochemistry. RESULTS: CIMP-low patients had a shorter cancer-specific survival compared with CIMP-negative patients (multivariate hazard ratio in NSHDS, 2.01; 95% confidence interval, 1.20-3.37; multivariate hazard ratio in CRUMS, 1.48; 95% confidence interval, 1.00-2.22). This result was similar in subgroups based on MSI screening status and was statistically significant in microsatellite stable (MSS) tumors in NSHDS. For CIMP-high patients, a shorter cancer-specific survival compared with CIMP-negative patients was observed in the MSS subgroup. Statistical significance was lost after adjusting for the BRAF mutation, but the main findings were generally unaffected. CONCLUSIONS: In this study, we found a poor prognosis in CIMP-low patients regardless of MSI screening status, and in CIMP-high patients with MSS. Although not consistently statistically significant, these results were consistent in two separate patient groups and emphasize the potential importance of CIMP and MSI status in colorectal cancer research.
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| 10. |
- Dahlin, Anna, 1979-
(författare)
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The CpG island methylator phenotype in colorectal cancer : studies on risk and prognosis
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background Colorectal cancer (CRC) is the second most common malignancy in developed countries. The mortality is high, with nearly half of patients dying from the disease. The primary treatment of CRC is surgery, and decisions about additional treatment with chemotherapy are based mainly on tumor stage. Novel prognostic markers that identify patients at high risk of recurrence and cancer-related death are needed. The development of CRC has been described in terms of two different pathways; the microsatellite instability (MSI) and chromosomal instability (microsatellite stable, MSS) pathway. More recently, the CpG island methylator phenotype (CIMP), characterized by frequent DNA hypermethylation, has been described as an alternative pathway of tumorigenesis. The event of DNA methylation is dependent on one-carbon metabolism, in which folate and vitamin B12 have essential functions. The purpose of this thesis was to study CIMP in CRC. The specific aims were to investigate the potential role of components of one-carbon metabolism as risk factors for this subgroup of tumors, and the prognostic importance of CIMP status, taking into consideration important confounding factors, such as MSI and tumor-infiltrating T cells. Methods CRC cases and referents included in the Northern Sweden Health and Disease Study (NSHDS, 226 cases and 437 referents) and CRC cases in the Colorectal Cancer in Umeå Study (CRUMS, n=490) were studied. Prediagnostic plasma concentrations of folate and vitamin B12 were analyzed in NSHDS. In both study groups, CIMP status was determined in archival tumor tissue by real-time quantitative PCR using an eight-gene panel (CDKN2A, MLH1, CACNA1G, NEUROG1, RUNX3, SOCS1, IGF2 and CRABP1). MSI screening status and the density of tumor-infiltrating T cells were determined by immunohistochemistry. Results An inverse association was found between plasma concentrations of vitamin B12 and rectal, but not colon, cancer risk. We also found a reduced risk of CIMP-high and CIMP-low CRC in study subjects with the lowest levels of plasma folate. We found that patients with CIMP-low tumors in both NSHDS and CRUMS had a poorer prognosis compared with CIMP-negative, regardless of MSI screening status. We also found that MSS CIMP-high patients had a poorer prognosis compared with MSS CIMP-negative. The density of tumor-infiltrating T cells and CIMP status were both found to be independent predictors of CRC patient prognosis. A particularly poor prognosis was found in patients with CIMP-low tumors poorly infiltrated by T cells. In addition, the density of T cells appeared to be more important than MSI screening status for predicting CRC patient prognosis. Conclusion Rather than being one disease, CRC is a heterogeneous set of diseases with respect to clinico-pathological and molecular characteristics. We found that the association between risk and plasma concentration of vitamin B12 and folate depends on tumor site and CIMP status, respectively. Patient prognosis was found to be different depending on CIMP and MSI screening status, and the density of tumor-infiltrating T cells.
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