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- Athan, E., et al.
(författare)
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Influence of vancomycin minimum inhibitory concentration on the outcome of methicillin-susceptible Staphylococcus aureus left-sided infective endocarditis treated with antistaphylococcal β-lactam antibiotics: a prospective cohort study by the International Collaboration on Endocarditis
- 2017
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Ingår i: Clinical Microbiology and Infection. - : Elsevier BV. - 1198-743X .- 1469-0691. ; 23, s. 544-549
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Tidskriftsartikel (refereegranskat)abstract
- © 2017 European Society of Clinical Microbiology and Infectious Diseases Objectives Left-sided methicillin-susceptible Staphylococcus aureus (MSSA) endocarditis treated with cloxacillin has a poorer prognosis when the vancomycin minimum inhibitory concentration (MIC) is ≥1.5 mg/L. We aimed to validate this using the International Collaboration on Endocarditis cohort and to analyse whether specific genetic characteristics were associated with a high vancomycin MIC (≥1.5 mg/L) phenotype. Methods All patients with left-sided MSSA infective endocarditis treated with antistaphylococcal β-lactam antibiotics between 2000 and 2006 with available isolates were included. Vancomycin MIC was determined by Etest as either high (≥1.5 mg/L) or low (<1.5 mg/L). Isolates underwent spa typing to infer clonal complexes and multiplex PCR for identifying virulence genes. Univariate analysis was performed to evaluate the association between in-hospital and 1-year mortality, and vancomycin MIC phenotype. Results Sixty-two cases met the inclusion criteria. Vancomycin MIC was low in 28 cases (45%) and high in 34 cases (55%). No significant differences in patient demographic data or characteristics of infection were observed between patients with infective endocarditis due to high and low vancomycin MIC isolates. Isolates with high and low vancomycin MIC had similar distributions of virulence genes and clonal lineages. In-hospital and 1-year mortality did not differ significantly between the two groups (32% (9/28) vs. 27% (9/34), p 0.780; and 43% (12/28) vs. 29% (10/34), p 0.298, for low and high vancomycin MIC respectively). Conclusions In this international cohort of patients with left-sided MSSA endocarditis treated with antistaphylococcal β-lactams, vancomycin MIC phenotype was not associated with patient demographics, clinical outcome or virulence gene repertoire.
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- De Angelis, A., et al.
(författare)
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Science with e-ASTROGAM A space mission for MeV-GeV gamma-ray astrophysics
- 2018
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Ingår i: Journal of High Energy Astrophysics. - : Elsevier. - 2214-4048 .- 2214-4056. ; 19, s. 1-106
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Tidskriftsartikel (refereegranskat)abstract
- e-ASTROGAM ('enhanced ASTROGAM') is a breakthrough Observatory space mission, with a detector composed by a Silicon tracker, a calorimeter, and an anticoincidence system, dedicated to the study of the non-thermal Universe in the photon energy range from 0.3 MeV to 3 GeV - the lower energy limit can be pushed to energies as low as 150 keV for the tracker, and to 30 keV for calorimetric detection. The mission is based on an advanced space-proven detector technology, with unprecedented sensitivity, angular and energy resolution, combined with polarimetric capability. Thanks to its performance in the MeV-GeV domain, substantially improving its predecessors, e-ASTROGAM will open a new window on the non-thermal Universe, making pioneering observations of the most powerful Galactic and extragalactic sources, elucidating the nature of their relativistic outflows and their effects on the surroundings. With a line sensitivity in the MeV energy range one to two orders of magnitude better than previous generation instruments, e-ASTROGAM will determine the origin of key isotopes fundamental for the understanding of supernova explosion and the chemical evolution of our Galaxy. The mission will provide unique data of significant interest to a broad astronomical community, complementary to powerful observatories such as LIGO-Virgo-GEO600-KAGRA, SKA, ALMA, E-ELT, TMT, LSST, JWST, Athena, CTA, IceCube, KM3NeT, and LISA.
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- Dumke, Roger, et al.
(författare)
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Multi-center evaluation of one commercial and 12 in-house real-time PCR assays for detection of Mycoplasma pneumoniae
- 2017
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Ingår i: Diagnostic microbiology and infectious disease. - : ELSEVIER SCIENCE INC. - 0732-8893 .- 1879-0070. ; 88:2, s. 111-114
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Tidskriftsartikel (refereegranskat)abstract
- Detection of Mycoplasma pneumoniae by real-time PCR is not yet standardized across laboratories. We have implemented a standardization protocol to compare the performance of thirteen commercial and in-house approaches. Despite differences on threshold values of samples, all assays were able to detect at least 20 M. pneumoniae genomes per reaction.
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- Pauletto, Franco, 1968-, et al.
(författare)
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Claiming epistemic access : eh ciò-prefaced turns in Trevigiano and in regional Italian
- 2022
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Ingår i: Journal of Pragmatics. - : Elsevier BV. - 0378-2166 .- 1879-1387. ; 190, s. 110-122
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Tidskriftsartikel (refereegranskat)abstract
- This conversation analytic study describes the interactional uses of ciò [ʧɔ], a pragmatic particle that is used both in the regional Italian spoken in Veneto (a region of northeastern Italy) and in Trevigiano (Trevixàn [trevi’zaŋ]), an Italo-Romance variety widely used in the Treviso area. Preliminary results show that ciò (derived from the imperative form of the verb ciór/tòr ([ʧor]/[tɔr] ‘to take’) is mostly used as a preface in responsive position and is frequently preceded by the particle eh. In our data, the (eh) ciò-prefaced turns are designed as general, objective, obvious contributions through which participants provide a wider perspective on the topic while treating the preceding talk as defective or not dealing with relevant aspects of the subject under discussion. This study contributes to the documentation of linguistic forms that are used by speakers of an Italo-Romance variety as conversational resources in talk-in-interaction.
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- Pauletto, Franco, 1968-, et al.
(författare)
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“Eh ciò, Sergio el xe stà anca sfortunà” – Il segnale discorsivo ciò in dialetto trevigiano e nell’italiano regionale parlato in provincia di Treviso: una rassegna di alcuni suoi usi nel parlato in interazione
- 2021
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Ingår i: Cuadernos de Filología Italiana. - : Universidad Complutense de Madrid (UCM). - 1133-9527 .- 1988-2394. ; 28, s. 153-183
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Tidskriftsartikel (refereegranskat)abstract
- This conversation analytic study describes the uses of ciò ([ʧɔ]) in talk-in-interaction. This discourse marker is documented as a linguistic resource in several Venetan Italo-Romance varieties still widely spoken in the Veneto region, and it is also frequently used in the regional Italian spoken in that area. The data come from informal telephone calls and from family dinner conversations in both Italian and Trevigiano ([trevi’zaŋ]), which is a dialect spoken in the Treviso area. Preliminary results show that ciò (derived from the imperative form of the Venetan verb ciór / tór / tòr ([ʧor] / [tor] / [tɔr], ‘to take’)) is mainly mobilized as turn preface, often preceded by other particles. However, ciò is also found within the turn and, in a limited number of cases, in turn-final position. From a sequential point of view, in our data ciò occurs almost exclusively in responsive turns. This study shows that a conversation analytic approach yields a much more comprehensive understanding not only of specific structures of spoken languages but also of the complex relations existing between different linguistic varieties in Italy.
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| 7. |
- Pauletto, Franco, 1968-, et al.
(författare)
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Histoire d’öh : Alcuni usi conversazionali di ”öh” ([ø]) nel parlato italo-romanzo
- 2023
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Ingår i: Studi Italiani di Linguistica Teorica e Applicata. - 0390-6809. ; :2, s. 356-382
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Tidskriftsartikel (refereegranskat)abstract
- This qualitative study aims to describe some interactional uses of öh [ø], a commonly used particle both in Italian and in other Italian-Romance varieties, from the perspective of conversation analysis (Schegloff, 2007). The research is based on a corpus of 59 instances from informal phone calls between friends, face-to-face conversations, and interviews in standard and regional Italian. The analysis shows that öh appears in responsive turns both as a free-standing turn-constructional unit and as a turn preface, either alone or in combination with other words. In the sequential context analyzed here - the response to a polar question, a B-event statement (i.e., a statement that indicate privileged, first-hand knowledge to a topic by the interlocutor, and which is usually treated as request for confirmation; cf. Labov and Fanshel, 1977: 100) or other types of informational turns - öh is used by participants to confirm from an epistemically qualified position. Finally, öh can take on distinct prosodic contours, lending itself to remarkable modulations that can emphasize the participant’s stance (cf. Gardner 2001).
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| 9. |
- Veres, P., et al.
(författare)
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Observation of inverse Compton emission from a long gamma-ray burst
- 2019
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Ingår i: Nature. - : NATURE PUBLISHING GROUP. - 0028-0836 .- 1476-4687. ; 575:7783, s. 459-
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Tidskriftsartikel (refereegranskat)abstract
- Long-duration gamma-ray bursts (GRBs) originate from ultra-relativistic jets launched from the collapsing cores of dying massive stars. They are characterized by an initial phase of bright and highly variable radiation in the kiloelectron volt-to-mega electronvoltband, which is probably produced within the jet and lasts from milliseconds to minutes, known as the prompt emission(1,2). Subsequently, the interaction of the jet with the surrounding medium generates shock waves that are responsible for the afterglow emission, which lasts from days to months and occurs over a broad energy range from the radio to the gigaelectronvolt bands(1-6). The afterglow emission is generally well explained as synchrotron radiation emitted by electrons accelerated by the external shock(7-9). Recently, intense long-lasting emission between 0.2 and 1 teraelectronvolts was observed from GRB 190114C(10,11). Here we report multifrequency observations of GRB 190114C, and study the evolution in time of the GRB emission across 17 orders of magnitude in energy, from 5 x 10(-6) to 10(12) electronvolts. We find that the broadband spectral energy distribution is double-peaked, with the teraelectronvolt emission constituting a distinct spectral component with power comparable to the synchrotron component. This component is associated with the afterglow and is satisfactorily explained by inverse Compton up-scattering of synchrotron photons by high-energy electrons. We find that the conditions required to account for the observed teraelectronvolt component are typical for GRBs, supporting the possibility that inverse Compton emission is commonly produced in GRBs.
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