| 1. |
- Abdelhak, Ahmed, et al.
(författare)
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Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations: an individual participant data meta-analysis.
- 2023
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Ingår i: Journal of neurology. - : Springer. - 1432-1459 .- 0340-5354. ; 270:7, s. 3315-3328
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Tidskriftsartikel (refereegranskat)abstract
- To investigate the prognostic value of blood neurofilament light chain protein (NfL) levels in the acute phase of coronavirus disease 2019 (COVID-19).We conducted an individual participant data (IPD) meta-analysis after screening on MEDLINE and Scopus to May 23rd2022. We included studies with hospitalized adult COVID-19 patients without major COVID-19-associated central nervous system (CNS) manifestations and with a measurement of blood NfL in the acute phase as well as data regarding at least one clinical outcome including intensive care unit (ICU)admission, need of mechanical ventilation (MV) and death. We derived the age-adjusted measures NfL Z scores and conducted mixed-effects modelling to test associations between NfL Z scores and other variables, encompassing clinical outcomes. Summary receiver operating characteristic curves (SROCs) were used to calculate the area under the curve (AUC) for blood NfL.We identified 382 records, of which 7 studies were included with a total of 669 hospitalized COVID-19 cases (mean age 66.2±15.0years, 68.1% males). Median NfL Z score at admission was elevated compared to the age-corrected reference population (2.37, IQR: 1.13-3.06, referring to 99th percentile in healthy controls). NfL Z scores were significantly associated with disease duration and severity. Higher NfL Z scores were associated with ahigher likelihood of ICU admission, need ofMV, and death. SROCs revealed AUCs of 0.74, 0.80 and 0.71 for mortality, need ofMV and ICU admission, respectively.Blood NfL levels were elevated in the acute phase of COVID-19 patients without major CNS manifestations and associated with clinical severity and poor outcome. The marker might ameliorate the performance of prognostic multivariable algorithms in COVID-19.
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| 2. |
- Abu-Rumeileh, Samir, et al.
(författare)
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The multifaceted role of neurofilament light chain protein in non-primary neurological diseases.
- 2023
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Ingår i: Brain : a journal of neurology. - : Oxford University Press (OUP). - 1460-2156. ; 146:2, s. 421-437
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Tidskriftsartikel (refereegranskat)abstract
- The advancing validation and exploitation of cerebrospinal fluid and blood neurofilament light chain protein as a biomarker of neuroaxonal damage has deeply changed the current diagnostic and prognostic approach to neurological diseases. Further, recent studies have provided evidence of potential new applications of this biomarker also in non-primary neurological diseases. In the present review we summarise the current evidence, future perspectives, but also limitations, of neurofilament light chain protein as a cerebrospinal fluid and blood biomarker in several medical fields, including intensive care, surgery, internal medicine and psychiatry. In particular, neurofilament light chain protein is associated with the degree of neurologic impairment and outcome in patients admitted to intensive care units or in the perioperative phase and it seems to be highly interconnected with cardiovascular risk factors. Beyond that, interesting diagnostic and prognostic insights have been provided by the investigation of neurofilament light chain protein in psychiatric disorders as well as in the current coronavirus disease 19 (COVID-19) pandemic and in normal aging. Altogether, current data outline a multifaceted applicability of cerebrospinal fluid and blood neurofilament light chain protein ranging from the critical clinical setting to the development of precision medicine models suggesting a strict interplay between the nervous system pathophysiology and the health-illness continuum.
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| 3. |
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| 4. |
- Ait Lahna, Abdelhak, et al.
(författare)
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Revised stratigraphic framework for the lower Anti-Atlas supergroup based on U–Pb geochronology of magmatic and detrital zircons (Zenaga and Bou Azzer-El Graara inliers, Anti-Atlas Belt, Morocco)
- 2020
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Ingår i: Journal of African Earth Sciences. - : Elsevier BV. - 1464-343X. ; 171
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Tidskriftsartikel (refereegranskat)abstract
- U–Pb geochronology of magmatic and detrital zircons (Zenaga and Bou Azzer-El Graara inliers, Anti-Atlas Belt, Morocco) and a reassessment of the published constraints suggest a revised stratigraphic framework for the lower Anti-Atlas Supergroup. Five major unconformity-bounded lithostratigraphic packages are here distinguished: the two lower units of Paleoproterozoic age are named the Tasserda-Taghatine Group (2030–1706 Ma) and the Oumoula (Mimount) Formation (ca. 1745–1650 Ma); the third unit of Paleoproterozoic to Neoproterozoic age (ca. 1650 to >883 Ma) is the Tizi n'Taghatine Group; the fourth and fifth units of Neoproterozoic age are the ca. 883 Ma Tachdamt and the ca. 700 Ma Bleida formations. Implications of this revised stratigraphic framework include: 1) the Tasserda-Taghatine Group might be linked to the post-orogenic collapse after the Eburnean Orogeny; 2) the Tizi n'Taghatine Group might be ca. 1.1 Ga in age based on proposed correlation with the Taoudeni Basin succession in Mauritania; 3) the Bleida Formation likely reflects deposition in the foreland basin at the early stage of the Pan-African Orogeny; 4) the Oumoula (Mimount) Formation, Tizi n'Taghatine Group, and Tachdamt Formation potentially record extensional events within the Nuna/Columbia and Rodinia supercontinents; 5) the provenance of the lower Anti-Atlas Supergroup (based on our new detrital zircon dating) is mainly from the West African craton along with possible contributions from other cratons such as Amazonia and the Sahara Metacraton; 6) the flood basalt sequence of the Tachdamt Formation likely belongs to the ca. 885-883 Ma intraplate Iguerda-Taïfast Large Igneous Province (LIP) event defined by previously dated dykes in the Iguerda and Taïfast inliers; and 7) the 1650 Ma Zenaga LIP can be potentially linked with LIP magmatism in Baltica and Laurentia.
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| 6. |
- Khalil, Michael, et al.
(författare)
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Neurofilaments as biomarkers in neurological disorders - towards clinical application.
- 2024
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Ingår i: Nature Reviews Neurology. - 1759-4758 .- 1759-4766. ; 20:5, s. 269-287
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Tidskriftsartikel (refereegranskat)abstract
- Neurofilament proteins have been validated as specific body fluid biomarkers of neuro-axonal injury. The advent of highly sensitive analytical platforms that enable reliable quantification of neurofilaments in blood samples and simplify longitudinal follow-up has paved the way for the development of neurofilaments as a biomarker in clinical practice. Potential applications include assessment of disease activity, monitoring of treatment responses, and determining prognosis in many acute and chronic neurological disorders as well as their use as an outcome measure in trials of novel therapies. Progress has now moved the measurement of neurofilaments to the doorstep of routine clinical practice for the evaluation of individuals. In this Review, we first outline current knowledge on the structure and function of neurofilaments. We then discuss analytical and statistical approaches and challenges in determining neurofilament levels in different clinical contexts and assess the implications of neurofilament light chain (NfL) levels in normal ageing and the confounding factors that need to be considered when interpreting NfL measures. In addition, we summarize the current value and potential clinical applications of neurofilaments as a biomarker of neuro-axonal damage in a range of neurological disorders, including multiple sclerosis, Alzheimer disease, frontotemporal dementia, amyotrophic lateral sclerosis, stroke and cerebrovascular disease, traumatic brain injury, and Parkinson disease. We also consider the steps needed to complete the translation of neurofilaments from the laboratory to the management of neurological diseases in clinical practice.
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| 7. |
- Youbi, Nasrrddine, et al.
(författare)
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The Central Iapetus magmatic province : An updated review and link with the ca. 580 Ma Gaskiers glaciation
- 2020
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Ingår i: Geological Society of America Special Papers : Mass Extinctions, Volcanism, and Impacts: New Developments - Mass Extinctions, Volcanism, and Impacts: New Developments. - : Geological Society of America. - 0072-1077. ; 544, s. 35-66
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Bokkapitel (refereegranskat)abstract
- Large igneous provinces and associated silicic magmatism can have a significant global climatic effect, so we explored the relationship between the large igneous province record and the ca. 580 Ma Gaskiers glaciation. The late Ediacaran glaciation exists on at least 14 different paleocontinental blocks, and assuming synchroneity, this Gaskiers glaciation was likely of short duration, with estimates ranging from 1.6 m.y. to 340 k.y. The Central Iapetus magmatic province event found in Laurentia, Baltica, and West Africa consists of multiple pulses in the range 620–520 Ma, with the ca. 580 Ma pulse particularly well developed in North Africa. Based on the age matches of 580–570 Ma Central Iapetus magmatic province pulses and the Gaskiers glaciation, and taking into consideration that there is no robust evidence for a major meteorite impact at the time of the Gaskiers onset, we propose that: (1) the initial silicic ca. 580 Ma pulse of the Ouarzazate event (Anti-Atlas of Morocco) helped to trigger the Gaskiers glaciation, and (2) global warming associated with the subsequent ca. 579–570 Ma continental flood basalts, marking the second stage of the Ouarzazate event, helped to end the ice age.
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