| 1. |
- Crespo, Abel, et al.
(författare)
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Exploring the influence of the substituent at position 4 in a series of 3,4-dihydropyrimidin-2(1H)-one A(2B) adenosine receptor antagonists
- 2017
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Ingår i: Chemistry of Heterocyclic Compounds. - : Springer. - 0009-3122 .- 1573-8353. ; 53:3, s. 316-321
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Tidskriftsartikel (refereegranskat)abstract
- In the context of a program to identify selective adenosine A(2B) receptor antagonists, we have obtained a focused library of 4-substituted 3,4-dihydropyrimidin-2(1H)-ones and its affinity for the four human adenosine receptor subtypes was determined. The synthesis was accomplished by using an experimentally simple and efficient Biginelli approach. The biological evaluation of the library revealed that all the documented derivatives exhibit low or negligible affinity for the A(2B) receptor, thus highlighting the critical importance of the substituent at position 4 of the 3,4-dihydropyrimidin-2(1H)-one chemotype.
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| 2. |
- Fiorini, Sandro, et al.
(författare)
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Representing part-whole relations in conceptual space
- 2014
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Ingår i: Cognitive Processing. - : Springer Science and Business Media LLC. - 1612-4782 .- 1612-4790. ; 15:2, s. 127-142
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we propose a cognitive semantic approach to represent part–whole relations. We base our proposal on the theory of conceptual spaces, focusing on prototypical structures in part–whole relations. Prototypical structures are not accounted for in traditional mereological formalisms. In our account, parts and wholes are represented in distinct conceptual spaces; parts are joined to form wholes in a structure space. The structure space allows systematic similarity judgments between wholes, taking into consideration shared parts and their configurations. A point in the structure space denotes a particular part structure; regions in the space represent different general types of part structures. We argue that the structural space can represent prototype effects: structural types are formed around typical arrangements of parts. We also show how structure space captures the variations in part structure of a given concept across different domains. In addition, we discuss how some taxonomies of part–whole relations can be understood within our framework.
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