| 1. |
- Gohir, Sameer Akram, et al.
(författare)
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Effectiveness of Internet-Based Exercises Aimed at Treating Knee Osteoarthritis : The iBEAT-OA Randomized Clinical Trial
- 2021
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Ingår i: JAMA Network Open. - : American Medical Association (AMA). - 2574-3805. ; 4:2, s. 210012-210012
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Tidskriftsartikel (refereegranskat)abstract
- Importance: Osteoarthritis is a prevalent, debilitating, and costly chronic disease for which recommended first-line treatment is underused.Objective: To compare the effect of an internet-based treatment for knee osteoarthritis vs routine self-management (ie, usual care).Design, Setting, and Participants: This randomized clinical trial was conducted from October 2018 to March 2020. Participants included individuals aged 45 years or older with a diagnosis of knee osteoarthritis recruited from an existing primary care database or from social media advertisements were invited. Data were analyzed April to July 2020.Interventions: The intervention and control group conformed to first-line knee osteoarthritis treatment. For the intervention group, treatment was delivered via a smartphone application. The control group received routine self-management care.Main Outcomes and Measures: The primary outcome was change from baseline to 6 weeks in self-reported pain during the last 7 days, reported on a numerical rating scale (NRS; range, 0-10, with 0 indicating no pain and 10, worst pain imaginable), compared between groups. Secondary outcomes included 2 physical functioning scores, hamstring and quadriceps muscle strength, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and quantitative sensory testing.Results: Among a total of 551 participants screened for eligibility, 146 were randomized and 105 were analyzed (mean [SD] age, 66.7 [9.2] years, 71 [67.1%] women), including 48 participants in the intervention group and 57 participants in the control group. There were no significant differences in baseline characteristics between the groups. At the 6-week follow-up, the intervention group showed a greater NRS pain score reduction than the control group (between-group difference, -1.5 [95% CI, -2.2 to -0.8]; P < .001). Similarly, the intervention group had better improvements in the 30-second sit-to-stand test (between-group difference, 3.4 [95% CI, 2.2 to 4.5]; P < .001) and Timed Up-and-Go test (between-group difference, -1.8 [95% CI, -3.0 to -0.5] seconds; P = .007), as well as the WOMAC subscales for pain (between-group difference, -1.1 [95% CI, -2.0 to -0.2]; P = .02), stiffness (between-group difference, -1.0 [95% CI, -1.5 to -0.5]; P < .001), and physical function (between-group difference, -3.4 [95% CI, -6.2 to -0.7]; P = .02). The magnitude of within-group changes in pain (d = 0.83) and function outcomes (30 second sit-to-stand test d = 1.24; Timed Up-and-Go test d = 0.76) in the intervention group corresponded to medium to very strong effects. No adverse events were reported.Conclusions and Relevance: These findings suggest that this internet-delivered, evidence-based, first-line osteoarthritis treatment was superior to routine self-managed usual care and could be provided without harm to people with osteoarthritis. Effect sizes observed in the intervention group corresponded to clinically important improvements.Trial Registration: ClinicalTrials.gov Identifier: NCT03545048.
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| 2. |
- Haugen, Ida K., et al.
(författare)
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Development of radiographic classification criteria for hand osteoarthritis : a methodological report (Phase 2)
- 2022
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Ingår i: RMD Open. - : BMJ. - 2056-5933. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- ObjectivesIn Phase 1 of developing new hand osteoarthritis (OA) classification criteria, features associated with hand OA were identified in a population with hand complaints. Radiographic findings could better discriminate patients with hand OA and controls than clinical examination findings. The objective of Phase 2 was to achieve consensus on the features and their weights to be included in three radiographic criteria sets of overall hand OA, interphalangeal OA and thumb base OA.MethodsMultidisciplinary, international expert panels were convened. Patient vignettes were used to identify important features consistent with hand OA. A consensus-based decision analysis approach implemented using 1000minds software was applied to identify the most important features and their relative importance influencing the likelihood of symptoms being due to hand OA. Analyses were repeated for interphalangeal and thumb base OA. The reliability and validity of the proposed criteria sets were tested.ResultsThe experts agreed that the criteria sets should be applied in a population with pain, aching or stiffness in hand joint(s) not explained by another disease or acute injury. In this setting, five additional criteria were considered important: age, morning stiffness, radiographic osteophytes, radiographic joint space narrowing and concordance between symptoms and radiographic findings. The reliability and validity were very good.ConclusionRadiographic features were considered critical when determining whether a patient had symptoms due to hand OA. The consensus-based decision analysis approach in Phase 2 complemented the data-driven results from Phase 1, which will form the basis of the final classification criteria sets.
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| 3. |
- Kundakci, Burak, et al.
(författare)
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International, multidisciplinary Delphi consensus recommendations on non-pharmacological interventions for fibromyalgia
- 2022
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Ingår i: Seminars in Arthritis & Rheumatism. - : Elsevier BV. - 0049-0172 .- 1532-866X. ; 57
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To develop evidence-based expert recommendations for non-pharmacological treatments for pain, fatigue, sleep problems, and depression in fibromyalgia.Methods: An international, multidisciplinary Delphi exercise was conducted. Authors of EULAR and the Canadian Fibromyalgia Guidelines Group, members of the American Pain Society and clinicians with expertise in fibromyalgia were invited. Participants were asked to select non-pharmacological interventions that could be offered for specific fibromyalgia symptoms and to classify them as either core or adjunctive treatments. An evidence summary was provided to aid the decision making. Items receiving >70% votes were accepted, those receiving <30% votes were rejected and those obtaining 30-70% votes were recirculated for up to two additional rounds.Results: Seventeen experts participated (Europe (n = 10), North America (n = 6), and Israel (n = 1)) in the Delphi exercise and completed all three rounds. Aerobic exercise, education, sleep hygiene and cognitive behavioural therapy were recommended as core treatments for all symptoms. Mind-body exercises were recommended as core interventions for pain, fatigue and sleep problems. Mindfulness was voted core treatment for depression, and adjunctive treatment for other symptoms. Other interventions, namely music, relaxation, hot bath, and local heat were voted as adjunctive treatments, varying between symptoms.Conclusions: This study provided evidence-based expert consensus recommendations on non-pharmacological treatments for fibromyalgia that may be used to individualise treatments in clinical practice targeting the diverse symptoms associated with fibromyalgia.
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| 4. |
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| 5. |
- Abbasi, Rasha, et al.
(författare)
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IceCube search for neutrinos from GRB 221009A
- 2023
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Ingår i: Proceedings of 38th International Cosmic Ray Conference (ICRC 2023). - : Sissa Medialab Srl.
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Konferensbidrag (refereegranskat)abstract
- GRB 221009A is the brightest Gamma Ray Burst (GRB) ever observed. The observed extremelyhigh flux of high and very-high-energy photons provide a unique opportunity to probe the predictedneutrino counterpart to the electromagnetic emission. We have used a variety of methods to searchfor neutrinos in coincidence with the GRB over several time windows during the precursor, promptand afterglow phases of the GRB. MeV scale neutrinos are studied using photo-multiplier ratescalers which are normally used to search for galactic core-collapse supernovae neutrinos. GeVneutrinos are searched starting with DeepCore triggers. These events don’t have directionallocalization, but instead can indicate an excess in the rate of events. 10 GeV - 1 TeV and >TeVneutrinos are searched using traditional neutrino point source methods which take into accountthe direction and time of events with DeepCore and the entire IceCube detector respectively. The>TeV results include both a fast-response analysis conducted by IceCube in real-time with timewindows of T0 − 1 to T0 + 2 hours and T0 ± 1 day around the time of GRB 221009A, as well asan offline analysis with 3 new time windows up to a time window of T0 − 1 to T0 + 14 days, thelongest time period we consider. The combination of observations by IceCube covers 9 ordersof magnitude in neutrino energy, from MeV to PeV, placing upper limits across the range forpredicted neutrino emission.
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| 6. |
- Abhishek, Sarabjot, et al.
(författare)
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Estimation of Uranium and Related Health Risks Due to Consumption of Groundwater in Lower Himalayas
- 2023
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Ingår i: Indian Journal of Pure & Applied Physics. - : CSIR-National Institute of Science Communication and Policy Research (NIScPR). - 0019-5596 .- 0975-1041. ; 61:6, s. 478-483
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Tidskriftsartikel (refereegranskat)abstract
- Exposure to uranium via ingestion of edible products may lead to serious health hazards when taken in quantities more than recommended limit. Hence, to assess the uranium content in groundwater and concerned health hazards 64 groundwater samples were collected from Hamirpur and Mandi districts of Himachal Pradesh. The samples were collected in pre monsoon season from the handpumps and bowries. The region lies in Lower Himalayan range which is storehouse of various granatic rocks. Presence of uranium deposits in Tileli (Mandi), Rajpura (Una), Lambehra (Hamirpur) makes the area more vulnerable for the study. The groundwater samples were analysed to measure concentration of uranium using LED Fluorimeter developed by Quantalase Private. Limited. The uranium concentration in groundwater samples varied from 0.25 to 17.29 & mu;g L-1, with an average value of 1.97. Uranium concentration in none of the samples surpassed the limit of 30 & mu;g L-1 recommended by WHO(2011), 60 & mu;g L-1 set by AERB(2004). Health risks were estimated in terms radiological and chemical toxicity for different isotopes of uranium. The calculated average mortality and morbidity risks were lower than the actual prescribed limit. The average Lifetime Average Daily Dose (LADD) was calculated as 0.04 and Hazard Quotient (HQ) below unity. Annual ingestion doses for different age groups were also measured which lies under safe limit. Thus, it is recommended that the groundwater is safe for consumption by public. Using Hair Compartment Model for uranium and mean daily uranium intake of 2.71 & mu;g for 60-year exposure period, organ specific doses due to uranium radioisotopes in prime organs/tissues and excretion rates via urine, faeces and hair pathway are estimated.
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| 7. |
- Abolfathi, Bela, et al.
(författare)
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The Fourteenth Data Release of the Sloan Digital Sky Survey : First Spectroscopic Data from the Extended Baryon Oscillation Spectroscopic Survey and from the Second Phase of the Apache Point Observatory Galactic Evolution Experiment
- 2018
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Ingår i: Astrophysical Journal Supplement Series. - : IOP Publishing Ltd. - 0067-0049 .- 1538-4365. ; 235:2
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Tidskriftsartikel (refereegranskat)abstract
- The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since 2014 July. This paper describes the second data release from this phase, and the 14th from SDSS overall (making this Data Release Fourteen or DR14). This release makes the data taken by SDSS-IV in its first two years of operation (2014-2016 July) public. Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey; the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data-driven machine-learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from the SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS web site (www.sdss.org) has been updated for this release and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020 and will be followed by SDSS-V.
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| 8. |
- Agarwal, Abhishek, et al.
(författare)
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Higher charges in dynamical spin chains for SYM theory
- 2005
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Ingår i: Journal of High Energy Physics. - : Springer Science and Business Media LLC. - 1029-8479 .- 1126-6708. ; :10, s. 1291-1302
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Tidskriftsartikel (refereegranskat)abstract
- We construct, to the first two non-trivial orders, the next conserved charge in the su(2|3) sector of N=4 Super Yang-Mills theory. This represents a test of integrability in a sector where the interactions change the number of sites of the chain. The expression for the charge is completely determined by the algebra and can be written in a diagrammatic form in terms of the interactions already present in the Hamiltonian. It appears likely that this diagrammatic expression remains valid in the full theory and can be generalized to higher loops and higher charges thus helping in establishing complete integrability for these dynamical chains.
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| 9. |
- Agarwal, Abhishek, et al.
(författare)
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Scattering amplitudes of massive N = 2 gauge theories in three dimensions
- 2014
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 89:4, s. 045020-
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Tidskriftsartikel (refereegranskat)abstract
- We study the scattering amplitudes of mass-deformed Chern-Simons theories and Yang-Mills-Chern-Simons theories with N = 2 supersymmetry in three dimensions. In particular, we derive the on-shell supersymmetry algebras which underlie the scattering matrices of these theories. We then compute various 3 and 4-point on-shell tree-level amplitudes in these theories. For the mass-deformed Chern-Simons theory, odd-point amplitudes vanish and we find that all of the 4-point amplitudes can be encoded elegantly in superamplitudes. For the Yang-Mills-Chern-Simons theory, we obtain all of the 4-point tree-level amplitudes using a combination of perturbative techniques and algebraic constraints and we comment on difficulties related to computing amplitudes with external gauge fields using Feynman diagrams. Finally, we propose a Britto-Cachazo-Feng-Witten recursion relation for mass-deformed theories in three dimensions and discuss the applicability of this proposal to mass-deformed N = 2 theories.
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