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District data management, modelling and visualization via interoperability
- 2017
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Proceedings (redaktörskap) (refereegranskat)abstract
- Data management has been one of the most interesting research fields within the smart city framework over the last years, with the aim of optimizing energy saving at district level. This topic involves the creation of a 3D city model considering heterogeneous datasets, such as Building Information Models (BIMs), Geographical Information Systems (GISs) and System Information Models (SIMs), taking into account both buildings and the energy network. Through the creation of a common platform, the data sharing was allowed starting from the needs of the users, such as the public administrator, the building manager and the energy professional. For this reason, the development of a District Information Modelling (DIM) methodology for the data management, related to the energy saving and CO2 emission, is considered the focus of this paper. It also presents a specific tool developed for the comparison of energy data in a selected district: the Benchmarking Tool.
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| 2. |
- Lion, T., et al.
(författare)
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The EuroChimerism concept for a standardized approach to chimerism analysis after allogeneic stem cell transplantation
- 2012
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Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 26:8, s. 1821-1828
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Tidskriftsartikel (refereegranskat)abstract
- Hematopoietic stem cell transplantation is becoming an increasingly important approach to treatment of different malignant and non-malignant disorders. There is thus growing demand for diagnostic assays permitting the surveillance of donor/recipient chimerism posttransplant. Current techniques are heterogeneous, rendering uniform evaluation and comparison of diagnostic results between centers difficult. Leading laboratories from 10 European countries have therefore performed a collaborative study supported by a European grant, the EuroChimerism Concerted Action, with the aim to develop a standardized diagnostic methodology for the detection and monitoring of chimerism in patients undergoing allogeneic stem cell transplantation. Following extensive analysis of a large set of microsatellite/short tandem repeat (STR) loci, the EuroChimerism (EUC) panel comprising 13 STR markers was established with the aim to optimally meet the specific requirements of quantitative chimerism analysis. Based on highly stringent selection criteria, the EUC panel provides multiple informative markers in any transplant setting. The standardized STR-PCR tests permit detection of donor-or recipient-derived cells at a sensitivity ranging between 0.8 and 1.6%. Moreover, the EUC assay facilitates accurate and reproducible quantification of donor and recipient hematopoietic cells. Wide use of the European-harmonized protocol for chimerism analysis presented will provide a basis for optimal diagnostic support and timely treatment decisions.
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