| 1. |
- John, Sternbeck, et al.
(författare)
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Organiska miljögifter i fisk från svenska bakgrundsområden
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Fisk från nio svenska lokaler, representerande sötvatten, kust och utsjö, har analyserats på PBDE (polybromerade difenyletrar), HBCD, PAH (polycykliska aromatiska kolväten), Klorerade bensener, PCB, ftalater, och klorerade dioxiner och furander i fiskmuskel. Dessutom har pentaklorfenol, triclosan och tetrabrombisfenol A analyserats i fiskgalla från tre av dessa lokaler.
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| 2. |
- Samuelsson, Linda, 1973, et al.
(författare)
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Using NMR metabolomics to identify responses of an environmental estrogen in blood plasma of fish
- 2006
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Ingår i: Aquatic Toxicology (Amsterdam, Netherlands). - : Elsevier BV. - 0166-445X. ; 78:4, s. 341-349
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Tidskriftsartikel (refereegranskat)abstract
- Nuclear magnetic resonance (NMR) based metabolomics in combination with multivariate data analysis may become valuable tools to study environmental effects of pharmaceuticals and other chemicals in aquatic organisms. To explore the usefulness of this approach in fish, we have used H-1 NMR metabolomics to compare blood plasma and plasma lipid extracts from rainbow trout exposed to the synthetic contraceptive estrogen ethinylestradiol (EE2) with plasma from control fish. The plasma metabolite profile was affected in fish exposed to 10 ng/L but not 0.87 ng/L of EE2, which was in agreement with an induced vitellogenin synthesis in the high dose group only, as measured by ELISA. The main affected metabolites were vitellogenin, alanine, phospholipids and cholesterol. The responses identified by this discovery-driven method could be put in context with previous knowledge of the effects of estrogens on fish. This adds confidence to the approach of using NMR metabolomics to identify environmental effects of pharmaceuticals and other contaminants. (c) 2006 Elsevier B.V. All rights reserved.
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| 3. |
- Stephensen, Eiríkur, et al.
(författare)
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Rubber additives induce oxidative stress in rainbow trout
- 2005
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Ingår i: Aquatic Toxicology. - : Elsevier BV. - 0166-445X. ; 75:2, s. 136-143
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Tidskriftsartikel (refereegranskat)abstract
- Several studies have demonstrated the toxicity of rubber leachate, mainly from rubber tires, to aquatic organisms. In the present study rainbow trout (Oncorhynchus mykiss) were exposed to water provided to aquaria through a rubber hose. Increased hepatic ethoxyresorufin-O-deethylase (EROD) activity, and glutathione reductase (GR) activity were observed in the exposed fish. Two common rubber additives, 2-mercaptobenzothiazole (MBT) and diphenylamine (DPA) and structurally related compounds, were identified by chemical analyses of water samples as were hydroxylated polycyclic aromatic hydrocarbons. Metabolites of these compounds were also detected in the bile of exposed fish, as were some of the parent compounds. In a following experiment, we injected rainbow trout with DPA or MBT. Both compounds affected total glutathione (tGSH) concentration in liver and MBT caused an increase in hepatic GR and glutathione S-transferase (GST) activity as well. In DPA injected fish, hydroxylated DPA was the main metabolite in the bile. Our results indicate that rubber chemicals may leach into the water surroundings where they can be taken up and metabolised by fish. Some of these chemicals can lead to up-regulation of antioxidant defences as demonstrated with DPA and MBT injections. (c) 2005 Elsevier B.V. All rights reserved.
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| 4. |
- Sternbeck, John, et al.
(författare)
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Organiska miljögifter i fisk från svenska bakgrundslokaler
- 2004
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Fisk från nio svenska lokaler, representerande sötvatten, kust och utsjö, har analyserats på PBDE (polybromerade difenyletrar), HBCD, PAH (polycykliska aromatiska kolväten), klorerade bensener, PCB, ftalater, och klorerade dioxiner och furaner i fiskmuskel. Dessutom har pentaklorfenol, triclosan och tetrabrombisfenol A analyserats i fiskgalla från tre av dessa lokaler.
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