| 1. |
- Tran, K. B., et al.
(författare)
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The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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Ingår i: Lancet. - 0140-6736. ; 400:10352, s. 563-591
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Tidskriftsartikel (refereegranskat)abstract
- Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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| 2. |
- Sumaila, U. Rashid, et al.
(författare)
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WTO must ban harmful fisheries subsidies
- 2021
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 374:6567, s. 544-544
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Afrin, S., et al.
(författare)
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Mental health status of adolescents in-home quarantine : a multi-region, cross-sectional study during COVID-19 pandemic in Bangladesh
- 2022
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Ingår i: BMC Psychology. - : Springer Science and Business Media LLC. - 2050-7283. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: The population's mental and physical health worldwide are currently at risk due to the coronavirus pandemic. We evaluated the mental health status of the adolescents trapped indoors because of the precautionary restrictions and prolonged closure of the educational institutions. Method: A cross-sectional study was conducted on adolescents from multiple urban and semi-urban areas of Bangladesh from 22 January to 3 February 2021. A self-reported online questionnaire containing questions regarding sociodemographic factors, home quarantine-related factors and mental health symptoms was distributed to collect data. Descriptive analysis, bivariate and multivariable logistic regressions were performed to measure the association of the variables. Cronbach's alpha was estimated to present the internal consistency of the scales. Results: A total of 322 adolescents (aged 12–19) with a mean age of 16.00 years (SD = 1.84) responded to the invitation. 54.97% (n = 177) of them were male, and the participants were predominantly urban residents (87.27%, n = 281). We observed varying degrees of depression in 67.08%, anxiety in 49.38% and stress in 40.68% of the participants according to DASS-21. Age, sex, education, mother's occupation, total monthly income, playing sports, doing household chores, going out of home, watching television, using the internet, attending online classes, changing food habits, and communicating with friends had a positive significant association with mental health burdens. Conclusion: Home quarantine has a noticeable adverse impact on the mental health of teenagers. Psychological evaluations and counselling via online and offline programs are essential to improve adolescents' declining mental health conditions.
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| 4. |
- Alam, M., et al.
(författare)
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Antigen-Specific Memory B-cell Responses to Enterotoxigenic Escherichia coli Infection in Bangladeshi Adults
- 2014
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Ingår i: PLoS Neglected Tropical Diseases. - : Public Library of Science (PLoS). - 1935-2727 .- 1935-2735. ; 8:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Multiple infections with diverse enterotoxigenic E. coli (ETEC) strains lead to broad spectrum protection against ETEC diarrhea. However, the precise mechanism of protection against ETEC infection is still unknown. Therefore, memory B cell responses and affinity maturation of antibodies to the specific ETEC antigens might be important to understand the mechanism of protection. Methodology: In this study, we investigated the heat labile toxin B subunit (LTB) and colonization factor antigens (CFA/I and CS6) specific IgA and IgG memory B cell responses in Bangladeshi adults (n = 52) who were infected with ETEC. We also investigated the avidity of IgA and IgG antibodies that developed after infection to these antigens. Principal Findings: Patients infected with ETEC expressing LT or LT+heat stable toxin (ST) and CFA/I group or CS6 colonization factors developed LTB, CFA/I or CS6 specific memory B cell responses at day 30 after infection. Similarly, these patients developed high avidity IgA and IgG antibodies to LTB, CFA/I or CS6 at day 7 that remained significantly elevated at day 30 when compared to the avidity of these specific antibodies at the acute stage of infection (day 2). The memory B cell responses, antibody avidity and other immune responses to CFA/I not only developed in patients infected with ETEC expressing CFA/I but also in those infected with ETEC expressing CFA/I cross-reacting epitopes. We also detected a significant positive correlation of LTB, CFA/I and CS6 specific memory B cell responses with the corresponding increase in antibody avidity. Conclusion: This study demonstrates that natural infection with ETEC induces memory B cells and high avidity antibodies to LTB and colonization factor CFA/I and CS6 antigens that could mediate anamnestic responses on re-exposure to ETEC and may help in understanding the requirements to design an effective vaccination strategies.
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| 5. |
- Akter, S, et al.
(författare)
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Production of active Exendin-4 in Nicotiana benthamiana and its application in treatment of type-2 diabetics
- 2022
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Ingår i: Frontiers in plant science. - : Frontiers Media SA. - 1664-462X. ; 13, s. 1062658-
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Tidskriftsartikel (refereegranskat)abstract
- GLP-1 (Glucagon-like peptide-1) is a peptide that stimulates insulin secretion from the β-cell for glycemic control of the plasma blood glucose level. Its mimetic exenatide (synthetic Exendin-4) with a longer half-life of approximately 3.3–4 h is widely used in clinical application to treat diabetes. Currently, exenatide is chemically synthesized. In this study, we report that the GLP-1 analogue recombinant Exendin-4 (Exdn-4) can be produced at a high level in Nicotiana benthamiana, with an estimated yield of 50.0 µg/g fresh biomass. For high-level expression, we generated a recombinant gene, B:GB1:ddCBD1m:8xHis : Exendin-4 (BGC : Exdn-4), for the production of Exendin-4 using various domains such as the BiP signal peptide, the GB1 domain (B1 domain of streptococcal G protein), a double cellulose binding domain 1 (CBD1), and 8 His residues (8xHis) to the N-terminus of Exendin-4. GB1 was used to increase the expression, whereas double CBD1 and 8xHis were included as affinity tags for easy purification using MCC beads and Ni2+-NTA resin, respectively. BGC : Exdn-4 was purified by single-step purification to near homogeneity using both Ni2+-NTA resin and microcrystalline cellulose (MCC) beads. Moreover, Exdn-4 without any extra residues was produced from BGC : Exdn-4 bound onto MCC beads by treating with enterokinase. Plant-produced Exdn-4 (Exendin-4) was as effective as chemically synthesized Exendin-4 in glucose-induced insulin secretion (GIIS) from mouse MIN6m9 cells a pancreatic beta cell line.
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| 6. |
- Demiris, G., et al.
(författare)
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Patient-centered Applications : Use of Information Technology to Promote Disease Management and Wellness. A White Paper by the AMIA Knowledge in Motion Working Group
- 2008
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Ingår i: JAMIA Journal of the American Medical Informatics Association. - 1067-5027 .- 1527-974X. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- Advances in information technology (IT) enable a fundamental redesign of health care processes based on the use and integration of electronic communication at all levels. New communication technologies can support a transition from institution centric to patient-centric applications. This white paper defines key principles and challenges for designers, policy makers, and evaluators of patient-centered technologies for disease management and prevention. It reviews current and emerging trends, highlights challenges related to design, evaluation, reimbursement and usability, and reaches conclusions for next steps that will advance the domain. © 2008 J Am Med Inform Assoc.
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| 7. |
- Karim, Zoheb, et al.
(författare)
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Chapter 14: Bacterial cellulose : Preparation and characterization
- 2017
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Ingår i: Cellulose-Reinforced Nanofibre Composites: Production, Properties and Applications. - : Elsevier Inc.. - 9780081009659 - 9780081009574 ; , s. 327-340
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This chapter reports the most relevant aspects related to the isolation, production, and characterization of bacterial nanocellulose (BC). Furthermore, various used strains for high-yield production of BC were summarized. Some vital parameters (e.g., mode of culture, type of bioreactor, media, etc.) for high-yield production of BC were further exemplified. Moreover, various characterization techniques were reported to understand the physiochemical properties of BC. Specific focus has been given to morphological, structural, and mechanical characterization, to utilize these properties for further application. © 2017 Elsevier Ltd. All rights reserved.
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| 8. |
- Sethi, Jatin, et al.
(författare)
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Smart polymer coatings for protection from corrosion
- 2020
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Ingår i: Smart Polymer Nanocomposites. - : Elsevier BV. ; , s. 399-413
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- In this chapter, various novel and well-noted approaches for corrosion preventive coatings have been discussed. Very well-documented factors that affect the corrosion mechanism are environmental factors, metal, and surface conditions and are elaborated in detail. Various modern, highly approachable, and currently used coating approaches are expanded and explained. This chapter provides a full view of the modern techniques used for corrosion prevention and cure.
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| 9. |
- Singh, A. A., et al.
(författare)
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Green composites : Versatile material for future
- 2017
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Ingår i: Green Biocomposites. - Cham : Springer Verlag. ; , s. 29-44
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Bokkapitel (refereegranskat)abstract
- The growing concern towards environmental problems and the urgent need for more versatile environmental friendly materials has led to increasing attention about polymer composites, i.e. fillers/reinforcing materials coming from renewable sources and biodegradable, especially from forest. The composites usually referred to as “green”, can find several industrial applications as discussed in this chapter. Biodegradable polymers coming from natural resources are also one important constituent of green composites. This chapter provides tactic for readers regarding the materials used for the fabrication and specific application of green composites in various fields. Furthermore, a discussion of the major material attributes of green composites is provided. From these focuses, a series of balancing application properties are explained. The chapter concludes that green composites have potential for use in a number of applications, but as with all design, one must carefully match the material to the application.
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