| 1. |
- Aghbolagh, Mahdi Shahmohammadi, et al.
(författare)
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Aspects on mediated glucose oxidation at a supported cubic phase
- 2017
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Ingår i: Bioelectrochemistry. - : Elsevier. - 1567-5394 .- 1878-562X. ; 118, s. 8-13
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Tidskriftsartikel (refereegranskat)abstract
- A supported liquid crystalline cubic phase housing glucose oxidase on an electrode surface has been suggested as bio-anode in a biofuel. The purpose of this investigation is to clarify some aspect on the mediated enzymatic oxidation of glucose in such a bio-anode where the mediator ferrocene-carboxylic acid and glucose were dissolved in the solution. The enzyme glucose oxidase was housed in the water channels of the mono-olein cubic phase. The system was investigated with cyclic voltammetry at different scan rates and the temperature was varied between 15 degrees C and 30 degrees C. The diffusion coefficient of the mediator and also the film resistance was estimated showing a large decrease in the mass-transport properties as the temperature was decreased. The current from mediated oxidation of glucose at the electrode surface increased with decreasing film thickness. The transport of the mediator in the cubic phase was the rate-limiting step in the overall reaction, where the oxidation of glucose took place at the outer surface of the cubic phase.
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| 2. |
- Khani Meynaq, Mohammad Yaser, et al.
(författare)
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Investigation of metal ion interaction with a lipid cubic phase using electrochemical impedance spectroscopy
- 2016
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Ingår i: Journal of Colloid and Interface Science. - : Elsevier BV. - 0021-9797 .- 1095-7103. ; 482, s. 212-220
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Tidskriftsartikel (refereegranskat)abstract
- AbstractHypothesis Electrochemical impedance spectroscopy, EIS, can be used as a complementary technique to investigate ion interaction with the headgroup region in the aqueous channels of a lipid cubic phase, LCP. Experiments A freestanding membrane made of monoolein LCP was formed by filling a small aperture that separates two cell compartments. The cell compartments were filled with electrolyte solutions at two different ionic strengths: i.e.: 10 and 100 mM, of KCl, CsBr and CaCl2. Electrochemical impedance spectroscopy was recorded between two platinum electrodes that were present at each side of the membrane. Findings The membrane resistance and capacitance were estimated from equivalent circuit fitting of the impedance data. It was confirmed that calcium ions interacts strongly with the headgroup region in the aqueous channels giving significantly higher membrane resistances compared to monovalent alkali metal ions. The membrane capacitance with Ca2+(aq) in solution was concentration dependent, which for the first time indicates formation of two different cubic phases at these conditions.
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| 3. |
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| 4. |
- Shadmanesh, Javad, et al.
(författare)
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QSAR study of active human glucagon receptor antagonists by SW-MLR and SW-SVM methods
- 2014
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Ingår i: Medicinal Chemistry Research. - : Springer. - 1054-2523 .- 1554-8120. ; 23:5, s. 2639-2650
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Tidskriftsartikel (refereegranskat)abstract
- A linear quantitative structure-activity relationship model is given for modelling and predicting of human glucagon receptor activities. A dataset containing 37 human glucagon receptors with their corresponding inhibition activities were used. The whole dataset was divided into training and testing set by using hierarchical clustering technique. Seven variables were selected by the stepwise variable selection procedure. Multiple linear regressions (MLR) and support vector machine (SVM) were applied to model the relationship between biological activities and molecular descriptors. Both models could suggest satisfactory prediction results: MLR method presented squared correlation coefficients of R (2) for the training and test sets of 0.894 and 0.776, namely, and squared correlation coefficient of 0.999 and 0.824 was obtained for training and testing sets by SVM model, respectively. The prediction result of the SVM was superior to that obtained by MLR model. The given models have suitable predictability and stability and can culminate in designing novel and potent human glucagon receptor activities.
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