| 1. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Alvarez, Lluc, et al.
(författare)
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eProcessor: European, Extendable, Energy-Efficient, Extreme-Scale, Extensible, Processor Ecosystem
- 2023
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Ingår i: Proceedings of the 20th ACM International Conference on Computing Frontiers 2023, CF 2023. ; , s. 309-314
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Konferensbidrag (refereegranskat)abstract
- The eProcessor project aims at creating a RISC-V full stack ecosystem. The eProcessor architecture combines a high-performance out-of-order core with energy-efficient accelerators for vector processing and artificial intelligence with reduced-precision functional units. The design of this architecture follows a hardware/software co-design approach with relevant application use cases from the high-performance computing, bioinformatics and artificial intelligence domains. Two eProcessor prototypes will be developed based on two fabricated eProcessor ASICs integrated into a computer-on-module.
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| 3. |
- Isern, Joan, et al.
(författare)
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Self-Renewing Human Bone Marrow Mesenspheres Promote Hematopoietic Stem Cell Expansion
- 2013
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Ingår i: Cell Reports. - : Elsevier BV. - 2211-1247. ; 3:5, s. 1714-1724
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Tidskriftsartikel (refereegranskat)abstract
- Strategies for expanding hematopoietic stem cells (HSCs) include coculture with cells that recapitulate their natural microenvironment, such as bone marrow stromal stem/progenitor cells (BMSCs). Plastic-adherent BMSCs may be insufficient to preserve primitive HSCs. Here, we describe a method of isolating and culturing human BMSCs as nonadherent mesenchymal spheres. Human mesenspheres were derived from CD45(-) CD31(-) CD71(-) CD146(+) CD105(+) nestin(+) cells but could also be simply grown from fetal and adult BM CD45(-)-enriched cells. Human mesenspheres robustly differentiated into mesenchymal lineages. In culture conditions where they displayed a relatively undifferentiated phenotype, with decreased adherence to plastic and increased self-renewal, they promoted enhanced expansion of cord blood CD34(+) cells through secreted soluble factors. Expanded HSCs were serially transplantable in immunodeficient mice and significantly increased long-term human hematopoietic engraftment. These results pave the way for culture techniques that preserve the self-renewal of human BMSCs and their ability to support functional HSCs.
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| 4. |
- José Ferreiro, María, et al.
(författare)
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Drosophila melanogaster White Mutant w(1118) Undergo Retinal Degeneration
- 2018
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Ingår i: Frontiers in Neuroscience. - : Frontiers Media SA. - 1662-4548 .- 1662-453X. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Key scientific discoveries have resulted from genetic studies of Drosophila melanogaster, using a multitude of transgenic fly strains, the majority of which are constructed in a genetic background containing mutations in the white gene. Here we report that white mutant flies from w(1118) strain undergo retinal degeneration. We observed also that w(1118) mutants have progressive loss of climbing ability, shortened life span, as well as impaired resistance to various forms of stress. Retinal degeneration was abolished by transgenic expression of mini-white+ in the white null background w(1118). We conclude that beyond the classical eye-color phenotype, mutations in Drosophila white gene could impair several biological functions affecting parameters like mobility, life span and stress tolerance. Consequently, we suggest caution and attentiveness during the interpretation of old experiments employing white mutant flies and when planning new ones, especially within the research field of neurodegeneration and neuroprotection. We also encourage that the use of w(1118) strain as a wild-type control should be avoided.
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| 5. |
- Langner, J., et al.
(författare)
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Model-simulated source contributions to PM2.5 in Santiago and the central region of Chile
- 2020
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Ingår i: Aerosol and Air Quality Research. - : Taiwan Association for Aerosol Research. - 2071-1409 .- 1680-8584. ; 20:5, s. 1111-1126
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Tidskriftsartikel (refereegranskat)abstract
- The contributions to PM2.5 from different emission sectors across central Chile and the Santiago metropolitan area during summer/fall and winter have been evaluated using a chemical transport model. The simulations generally underestimate the mean PM2.5 concentrations compared to measurements conducted at stations in Santiago that belong to the Chilean National Air Quality Information System (SINCA). The potential reasons for this discrepancy include underestimated direct PM2.5 emissions, missing emissions for semi-and intermediately volatile organic compounds (SVOCs and IVOCs) and overestimated wind speeds in the simulations. The simulated winter PM2.5 concentrations in Santiago are lower and higher than the values observed during nighttime, and daytime and late evening, respectively, which may be related to excessive simulated wind speeds, as well as to uncertainties in the diurnal variation in the emissions. During summer/fall, the simulated diurnal variation better agrees with the observations, but the peak concentrations during the morning are underestimated, whereas those during the evening are overestimated. The simulated contributions of different aerosol components to the PM2.5 at one station in Santiago are all lower than the observed values, except for elemental carbon equivalent black carbon (BCe), which exhibit comparable or higher levels in the simulations. The absolute differences are the largest for the total organic matter, whereas the relative differences are the largest for BCe and ammonium. The simulated sector contributions indicate that emissions originating from transport and construction machinery dominate the PM2.5 in Santiago; however, residential wood combustion is the primary source in other urban areas of central Chile, except near major point sources. Away from urban areas, traffic routes and major industrial sources, secondary inorganic aerosol (SIA) is estimated to be the largest component of the aerosol, whereas the simulated secondary organic aerosol (SOA) only contributes a small fraction.
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