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Träfflista för sökning "WFRF:(Ahlberg L) "

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Numrering	Referens	Omslagsbild	Hitta
1.	Pedersen, TR, et al. (författare) Cholesterol lowering and the use of healthcare resources. Results of the Scandinavian Simvastatin Survival Study 1996 Ingår i: Circulation. - 0009-7322. ; 93:10, s. 1796-1802 Tidskriftsartikel (refereegranskat)
2.	Pinkney, T, et al. (författare) The relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit 2017 Ingår i: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. - : Wiley. - 1463-1318 .- 1462-8910. ; 19:8, s. O296-O311 Tidskriftsartikel (refereegranskat)
3.	Grip, L, et al. (författare) A low molecular weight, selective thrombin inhibitor, inogatran, vs heparin, in unstable coronary artery disease in 1209 patients. A double-blind, randomized, dose-finding study. Thrombin inhibition in Myocardial Ischaemia (TRIM) study group 1997 Ingår i: European heart journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 18:9, s. 1416-1425 Tidskriftsartikel (refereegranskat)
4.	Roselli, Carolina, et al. (författare) Multi-ethnic genome-wide association study for atrial fibrillation 2018 Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:9, s. 1225-1233 Tidskriftsartikel (refereegranskat)abstract Atrial fibrillation (AF) affects more than 33 million individuals worldwide(1) and has a complex heritability(2). We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.
5.	Wallentin, L, et al. (författare) Low-molecular-weight heparin during instability in coronary artery disease, Fragmin during Instability in Coronary Artery Disease (FRISC) study group 1996 Ingår i: Lancet (London, England). - 0140-6736. ; 347:9001, s. 561-568 Tidskriftsartikel (refereegranskat)
6.	Lindahl, B, et al. (författare) Risk stratification in unstable coronary artery disease. Additive value of troponin T determinations and pre-discharge exercise tests. FRISK Study Group 1997 Ingår i: European heart journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 18:5, s. 762-770 Tidskriftsartikel (refereegranskat)
7.	ANDERSEN, JT, et al. (författare) Can finasteride reverse the progress of benign prostatic hyperplasia? A two-year placebo-controlled study. The Scandinavian BPH Study Group 1995 Ingår i: Urology. - : Elsevier BV. - 0090-4295. ; 46:5, s. 631-637 Tidskriftsartikel (refereegranskat)
8.	Auner, HW, et al. (författare) Reduced-intensity conditioned allogeneic stem cell transplantation for multiple myeloma relapsing or progressing after autologous transplantation : a study by the European Group for Blood and Marrow Transplantation Chronic Malignancies Working Party 2013 Ingår i: BONE MARROW TRANSPLANTATION. - 0268-3369. ; 48, s. S17-S17 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
9.	Kogner, L, et al. (författare) Duration of first stage of labor, severe perineal lacerations and maternal complications in the early postpartum period 2023 Ingår i: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. - 0001-6349. ; 102, s. 7-7 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
10.	Young, William J., et al. (författare) Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways 2022 Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 13 Tidskriftsartikel (refereegranskat)abstract The QT interval is a heritable electrocardiographic measure associated with arrhythmia risk when prolonged. Here, the authors used a series of genetic analyses to identify genetic loci, pathways, therapeutic targets, and relationships with cardiovascular disease. The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes. Enrichments are observed in established pathways for QT and JT, and previously unreported genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast for QRS, connective tissue components and processes for cell growth and extracellular matrix interactions are significantly enriched. We demonstrate polygenic risk score associations with atrial fibrillation, conduction disease and sudden cardiac death. Prioritization of druggable genes highlight potential therapeutic targets for arrhythmia. Together, these results substantially advance our understanding of the genetic architecture of ventricular depolarization and repolarization.

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Författare/redaktör: Ahlberg, G (20); Ahlberg, M (18); Ahlberg, L (14); Stephansson, O (13); Edstrom, L (9); Lundborg, L (8); visa fler...; Sandstrom, A. (7); Nahi, H (6); Liu, XR (6); Aberg, K (5); Karlsson, K (5); Borg, K (5); Ahlberg, J (5); Tomaszewska-Toporska ... (5); Lauri, B (5); Thorson, A (4); Broutet, N (4); Knight, M (4); Wallentin, L (4); Lees, C. (4); Jones, S. (4); Regan, L (4); Svensson, O (4); Crispi, F (4); Ahlberg, E (4); Anvret, M (4); Brandt, JS (4); Lindahl, B (4); Gratacos, E (4); FORSBERG, K (4); Gustafsson, G. (4); von Dadelszen, P. (4); Gale, C. (4); Lanzone, A (4); Carrillo, J (4); Bernell, P. (4); Karbach, H. (4); Ferguson, K. (4); Bevilacqua, E (4); Nachega, JB (4); Hernandez, O. (4); Blimark, C (4); Temmerman, M (4); Magee, LA (4); Madhi, SA (4); Tolosa, JE (4); Favre, G (4); Hammarstrom, E (4); Whitehead, C (4); Smith, ER (4); visa färre...

Lärosäte: Karolinska Institutet (65); Uppsala universitet (22); Lunds universitet (8); Göteborgs universitet (7); Umeå universitet (7); Örebro universitet (6); visa fler...; Linköpings universitet (4); Kungliga Tekniska Högskolan (3); Chalmers tekniska högskola (3); RISE (1); visa färre...

Språk: Engelska (98); Svenska (2); Odefinierat språk (1)

Forskningsämne (UKÄ/SCB): Naturvetenskap (16); Medicin och hälsovetenskap (15); Teknik (4)

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