| 1. |
- Ahlgren, Erika, et al.
(författare)
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Association between Plasma Homocysteine Levels and Neuronal Injury in HIV Infection
- 2016
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:7
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Tidskriftsartikel (refereegranskat)abstract
- Objective To investigate the role of homocysteine in neuronal injury in HIV infection. Methods Using a cross-sectional design and archived samples, we compared concentrations of plasma homocysteine and cerebrospinal fluid (CSF) neurofilament light protein (NFL), a sensitive marker of neuronal injury, in 83 HIV-1-infected subjects without antiretroviral treatment. We also analyzed plasma vitamin B12, serum folate, CSF, and plasma HIV RNA, the immune activation marker neopterin in CSF and serum, and albumin ratio as a marker of blood-brain barrier integrity. Twenty-two subjects provided a second sample median of 12.5 months after antiretroviral treatment initiation. Results A significant correlation was found between plasma homocysteine and CSF NFL concentrations in untreated individuals (r = 0.52, p < 0.0001). As expected, there was a significant inverse correlation between homocysteine and B12 (r = -0.41, p < 0.001) and folate (r = -0.40, p = < 0.001) levels. In a multiple linear regression analysis homocysteine stood out as an independent predictor of CSF NFL in HIV-1-infected individuals. The correlation of plasma homocysteine and CSF NFL was also present in the group receiving antiretroviral therapy (r = 0.51, p = 0.016). Conclusion A correlation between plasma homocysteine and axonal injury, as measured by CSF NFL, was found in both untreated and treated HIV. While this study is not able to prove a causal link, homocysteine and functional B12/folate deficiency appear to play a role in neural injury in HIV-infected individuals.
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| 2. |
- Rogström, Lina, et al.
(författare)
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Age hardening in arc-evaporated ZrAlN thin films
- 2010
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Ingår i: Scripta Materialia. - Amsterdam : Elsevier Science B.V.. - 1359-6462 .- 1872-8456. ; 62:10, s. 739-741
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Tidskriftsartikel (refereegranskat)abstract
- Zr0.44Al0.56N1.20 films were deposited by reactive arc evaporation on WC-Co substrates. As-deposited films have a defect-rich NaCl-cubic and wurtzite phase mixture. During annealing at 1100 degrees C the films undergo simultaneous recovery of the ZrN-rich c-ZrAlN nanoscale domains and formation of semicoherent w-ZrAlN nanobricks, while the excess nitrogen is released. This process results in an age hardening effect as high as 36%, as determined by nanoindentation. At 1200 degrees C, the w-AlN recrystallizes and the hardening effect is lost.
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| 3. |
- Rogström, Lina, et al.
(författare)
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Thermal stability and mechanical properties of arc evaporated ZrN/ZrAlN multilayers
- 2010
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Ingår i: Thin Solid Films. - : Elsevier. - 0040-6090 .- 1879-2731. ; 519:2, s. 694-699
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Tidskriftsartikel (refereegranskat)abstract
- ZrN1.20/Zr0.44Al0.56N1.20 multilayer films as well as ZrN1.17 and Zr0.44Al0.56N1.20 films were deposited by reactive arc evaporation on WC–Co substrates. Samples were post-deposition annealed for 2 h at 800–1200 °C. As-deposited and heat treated films were characterized by scanning transmission electron microscopy, X-ray diffraction and nanoindentation. The thermal stability was studied using a combination of differential scanning calorimetry, thermogravimetry, and mass spectrometry. The as-deposited Zr0.44Al0.56N1.20 film exhibits a nanocomposite structure of cubic and wurtzite ZrAlN. During annealing, the formation of ZrN- and AlN-rich domains results in age hardening of both the Zr0.44Al0.56N1.20 and the ZrN/ZrAlN multilayers. The age hardening is enhanced in the ZrN/ZrAlN multilayer due to straining of the ZrAlN sublayers in which a maximum hardness of 31 GPa is obtained after annealing at 1100 °C.
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| 4. |
- Adolfsson, Jan, et al.
(författare)
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Clinical characteristics and primary treatment of prostate cancer in Sweden between 1996 and 2005 : Data from the national prostate cancer register in Sweden
- 2007
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Ingår i: Scandinavian Journal of Urology and Nephrology. - Stockholm : Taylor & Francis. - 0036-5599 .- 1651-2065. ; 41:6, s. 456-477
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Tidskriftsartikel (refereegranskat)abstract
- Objective. The incidence of prostate cancer is rising rapidly in Sweden and there is a need to better understand the pattern of diagnosis, tumor characteristics and treatment. Material and methods. Between 1996 and 2005, all new cases of adenocarcinoma of the prostate gland were intended to be registered in the National Prostate Cancer Register (NPCR). This register contains information on diagnosing unit, date of diagnosis, cause of diagnosis, tumor grade, tumor stage according to the TNM classification in force, serum prostate-specific antigen (PSA) levels at diagnosis and primary treatment given within the first 6 months after diagnosis. Results. In total, 72 028 patients were registered, comprising >97% of all pertinent incident cases of prostate cancer in the Swedish Cancer Register (SCR). During the study period there was a considerable decrease in median age at the time of diagnosis, a stage migration towards smaller tumors, a decrease in median serum PSA values at diagnosis, a decrease in the age-standardized incidence rate of men diagnosed with distant metastases or with a PSA level of >100 ng/ml at diagnosis and an increase in the proportion of tumors with Gleason score ≤6. Relatively large geographical differences in the median age at diagnosis and the age-standardized incidence of cases with category T1c tumors were observed. Treatment with curative intent increased dramatically and treatment patterns varied according to geographical region. In men with localized tumors and a PSA level of <20 ng/ml at diagnosis, expectant treatment was more commonly used in those aged ≥75 years than in those aged <75 years. Also, the pattern of endocrine treatment varied in different parts of Sweden. Conclusions. All changes in the register seen over time are consistent with increased diagnostic activity, especially PSA testing, resulting in an increased number of cases with early disease, predominantly tumors in category T1c. The patterns of diagnosis and treatment of prostate cancer vary considerably in different parts of Sweden. The NPCR continues to be an important source for research, epidemiological surveillance of the incidence, diagnosis and treatment of prostate cancer
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| 5. |
- Adolfsson, Jan, et al.
(författare)
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Clinical characteristics and primary treatment of prostate cancer in Sweden between 1996 and 2005
- 2007
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Ingår i: Scandinavian Journal of Urology and Nephrology. - : Informa UK Limited. - 0036-5599 .- 1651-2065. ; 41:6, s. 456-477
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The incidence of prostate cancer is rising rapidly in Sweden and there is a need to better understand the pattern of diagnosis, tumor characteristics and treatment. MATERIAL AND METHODS: Between 1996 and 2005, all new cases of adenocarcinoma of the prostate gland were intended to be registered in the National Prostate Cancer Register (NPCR). This register contains information on diagnosing unit, date of diagnosis, cause of diagnosis, tumor grade, tumor stage according to the TNM classification in force, serum prostate-specific antigen (PSA) levels at diagnosis and primary treatment given within the first 6 months after diagnosis. RESULTS: In total, 72,028 patients were registered, comprising >97% of all pertinent incident cases of prostate cancer in the Swedish Cancer Register (SCR). During the study period there was a considerable decrease in median age at the time of diagnosis, a stage migration towards smaller tumors, a decrease in median serum PSA values at diagnosis, a decrease in the age-standardized incidence rate of men diagnosed with distant metastases or with a PSA level of > 100 ng/ml at diagnosis and an increase in the proportion of tumors with Gleason score <6. Relatively large geographical differences in the median age at diagnosis and the age-standardized incidence of cases with category T1c tumors were observed. Treatment with curative intent increased dramatically and treatment patterns varied according to geographical region. In men with localized tumors and a PSA level of <20 ng/ml at diagnosis, expectant treatment was more commonly used in those aged > or =75 years than in those aged <75 years. Also, the pattern of endocrine treatment varied in different parts of Sweden. CONCLUSIONS: All changes in the register seen over time are consistent with increased diagnostic activity, especially PSA testing, resulting in an increased number of cases with early disease, predominantly tumors in category T1c. The patterns of diagnosis and treatment of prostate cancer vary considerably in different parts of Sweden. The NPCR continues to be an important source for research, epidemiological surveillance of the incidence, diagnosis and treatment of prostate cancer.
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| 6. |
- Ahlgren, Bengt, et al.
(författare)
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Ambient networks: Bridging heterogeneous network domains
- 2005. - 1
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Konferensbidrag (refereegranskat)abstract
- Providing end-to-end communication in heterogeneous internetworking environments is a challenge. Two fundamental problems are bridging between different internetworking technologies and hiding of network complexity and differences from both applications and application developers. This paper presents abstraction and naming mechanisms that address these challenges in the Ambient Networks project. Connectivity abstractions hide the differences of heterogeneous internetworking technologies and enable applications to operate across them. A common naming framework enables end-to-end communication across otherwise independent internetworks and supports advanced networking capabilities, such as indirection or delegation, through dynamic bindings between named entities.
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| 7. |
- Ahlgren, Bengt, et al.
(författare)
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Experiments with Subversion Over OpenNetInf and CCNx
- 2011. - 7
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Konferensbidrag (refereegranskat)abstract
- We describe experiences and insights from adapting the Subversion version control system to use the network service of two information-centric networking (ICN) prototypes: OpenNetInf and CCNx. The evaluation is done using a local collaboration scenario, common in our own project work where a group of people meet and share documents through a Subversion repository. The measurements show a performance benefit already with two clients in some of the studied scenarios, despite being done on un-optimised research prototypes. The conclusion is that ICN clearly is beneficial also for non mass-distribution applications.
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| 8. |
- Ahlgren, Bengt, et al.
(författare)
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Invariants: A New Design Methodology for Network Architectures
- 2004. - 1
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Konferensbidrag (refereegranskat)abstract
- The first age of Internet architectural thinking concentrated on defining the correct principles for designing a packet-switched network and its application protocol suites. Although these same principles remain valid today, they do not address the question of how to reason about the evolution of the Internet or its interworking with other networks of very different heritages. This paper proposes a complementary methodology, motivated by the view that evolution and interworking flexibility are determined not so much by the principles applied during initial design, but by the choice of fundamental components or "design invariants" in terms of which the design is expressed. The paper discusses the characteristics of such invariants, including examples from the Internet and other networks, and considers what attributes of invariants best support architectural flexibility.
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| 9. |
- Ahlgren, Bengt, et al.
(författare)
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Names, addresses and identities in ambient networks
- 2005. - 1
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Konferensbidrag (refereegranskat)abstract
- Ambient Networks interconnect independent realms that may use different local network technologies and may belong to different administrative or legal entities. At the core of these advanced internetworking concepts is a flexible naming architecture based on dynamic indirections between names, addresses and identities. This paper gives an overview of the connectivity abstractions of Ambient Networks and then describes its naming architecture in detail, comparing and contrasting them to other related next-generation network architectures.
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| 10. |
- Ahlgren, Bengt, et al.
(författare)
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Subversion over OpenNetInf and CCNx
- 2011
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Ingår i: Proceedings - Conference on Local Computer Networks, LCN. - 9781612849287 ; , s. 1056-1063
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Konferensbidrag (refereegranskat)abstract
- We describe experiences and insights from adapting the Subversion version control system to use the network service of two information-centric networking (ICN) prototypes: OpenNetInf and CCNx. The evaluation is done using a local collaboration scenario, common in our own project work where a group of people meet and share documents through a Subversion repository. The measurements show a performance benefit already with two clients in some of the studied scenarios, despite being done on un-optimised research prototypes. The conclusion is that ICN clearly is beneficial also for non mass-distribution applications. It was straightforward to adapt Subversion to fetch updated files from the repository using the ICN network service. The adaptation however neglected access control which will need a different approach in ICN than an authenticated SSL tunnel. Another insight from the experiments is that care needs to be taken when implementing the heavy ICN hash and signature calculations. In the prototypes, these are done serially, but we see an opportunity for parallelisation, making use of current multi-core processors.
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