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| 2. |
- Ahlin, Anders, et al.
(författare)
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Chronic granulomatous disease - haematopoietic stem cell transplantation versus conventional treatment.
- 2013
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Ingår i: Acta paediatrica (Oslo, Norway : 1992). - : Wiley. - 1651-2227 .- 0803-5253. ; 102:11, s. 1087-1094
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Tidskriftsartikel (refereegranskat)abstract
- Chronic granulomatous disease (CGD) is a rare X-linked or autosomal recessive primary immune deficiency characterized by recurrent, life-threatening bacterial and fungal infections. Mortality rates are high with conventional treatment. However, haematopoietic stem cell transplantation (HSCT) offers cure. Here, we compare the outcome of HSCT in 14 Swedish patients with CGD to that in 27 patients with CGD who were given conventional treatment.
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| 4. |
- Ahlin, Cecilia, et al.
(författare)
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Aberrant expression of cyclin E in low-risk node negative breast cancer
- 2008
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Ingår i: Acta Oncologica. - : Informa UK Limited. - 0284-186X .- 1651-226X. ; 47:8, s. 1539-1545
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Tidskriftsartikel (refereegranskat)abstract
- Background. Cyclin E is a cell cycle regulatory protein which occurs in G1, peaks in late G1 and is degraded in early S-phase. Cyclin E overexpression appears to be an independent prognostic factor for overall survival in breast cancer. Material and Methods. Nuclear cyclin A is a reliable marker for S-and G2-phases. Consequently, aberrant expression of cyclin E can be detected by simultaneous immunostainings for cyclin A and cyclin E. Studies have shown that aberrant cyclin E might provide additional prognostic information compared to that of cyclin E alone. This study aimed to investigate cyclin E and aberrant cyclin E expression in low-risk node negative breast cancer. We compared women that died from their breast cancer (n=17) with women free from relapse>8 years after initial diagnosis (n=24). All women had stage I, low risk breast cancer. The groups were matched regarding tumour size, receptor status, adjuvant chemotherapy and tumour differentiation. Tumour samples were analysed regarding expression of cyclin A, cyclin E and double-stained tumour cells using immunoflourescence staining and digital microscopy. Results. No differences were seen regarding expression of cyclin E or aberrant cyclin E in cases compared to controls. Discussion. We conclude that neither cyclin E nor aberrant cyclin E is a prognostic factor in low-risk node negative breast cancer patients.
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| 6. |
- Ahlin, Kjell, et al.
(författare)
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A smart way to analyze dynamic data
- 2003
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Ingår i: Sound & Vibration. - : Acoustical Publications, Inc.. - 1541-0161 .- 2693-1443. ; :February, s. 20-22
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In recent years MATLAB® has become a common software tool for general computational mathematics, in universities as well as in industry. In the field of noise and vibration analysis, MATLAB is very common in universities, but perhaps a little less common in the industrial world. In this article some ideas are presented on how MATLAB can be successfully used for analyzing experimental noise and vibration data. Through the introduction of toolboxes in this field, the less experienced user can take advantage of the powerful functionality of MATLAB, either as the main tool or as a complement to the many excellent menu driven systems available on the market. Some of the advantages and disadvantages of using MATLAB versus menu driven systems are also discussed.
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| 7. |
- Ahlin, Sofie, 1985, et al.
(författare)
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Macrophage Gene Expression in Adipose Tissue is Associated with Insulin Sensitivity and Serum Lipid Levels Independent of Obesity.
- 2013
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Ingår i: Obesity (Silver Spring, Md.). - : Wiley. - 1930-739X .- 1930-7381. ; 21:12
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Obesity is linked to both increased metabolic disturbances and increased adipose tissue macrophage infiltration. However, whether macrophage infiltration directly influences human metabolism is unclear. The aim of this study was to investigate if there are obesity-independent links between adipose tissue macrophages and metabolic disturbances. Design and Methods: Expression of macrophage markers in adipose tissue was analyzed by DNA microarrays in the SOS Sib Pair study and in patients with type 2 diabetes and a BMI-matched healthy control group. Results: The expression of macrophage markers in adipose tissue was increased in obesity and associated with several metabolic and anthropometric measurements. After adjustment for BMI, the expression remained associated with insulin sensitivity, serum levels of insulin, C-peptide, high density lipoprotein cholesterol (HDL-cholesterol) and triglycerides. In addition, the expression of most macrophage markers was significantly increased in patients with type 2 diabetes compared to the control group. Conclusion: Our study shows that infiltration of macrophages in human adipose tissue, estimated by the expression of macrophage markers, is increased in subjects with obesity and diabetes and associated with insulin sensitivity and serum lipid levels independent of BMI. This indicates that adipose tissue macrophages may contribute to the development of insulin resistance and dyslipidemia.
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| 8. |
- Brandt, Anders, et al.
(författare)
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A Digital Filter Method for Forced Response Computation
- 2003
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Konferensbidrag (refereegranskat)abstract
- Transient forced response of mechanical structures is usually computed using time domain integration. This is often computationally costly, and the numerical precision and stability are concerns. In the present paper, a novel method based on modal superposition, using a new digital filter implementation, is presented. Poles and residues of the model are used as input data, which allows for using data from a finite element model, a lumped parameter model, or from experimental modal analysis. Modal damping can be used if the damping matrix is unknown. With the proposed method, the frequency dependant error can easily be computed, and can be chosen arbitrarily small by selecting proper sampling frequency (time increment). The method is applicable to all linear structures and can be used for stationary or transient input data. Simulation results show that the new method is superior to the alternative methods, at less computational cost.
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