| 1. |
- Ahlin, Lena, et al.
(författare)
-
Narrativ teknik och känsla i Hemingways "Hills Like White Elephants"
- 2023
-
Ingår i: Litteraturdidaktik och känslor: Konferensvolym 2021. - : Stockholm University Press.
-
Bokkapitel (populärvet., debatt m.m.)abstract
- I kapitlet ”Narrativ teknik och känsla i Hemingways ’Hills Like White Elephants’” utgår vi från frågan om det huruvida samtidigt vara känslomässigt berörd av en text och förhålla sig kritiskt till den. I en undersökning av förhållandet mellan estetisk form och känslor argumenterar vi för att kritisk närläsning kan vara ett helt nödvändigt första steg för att uppfatta karaktärers känslor och för att som läsare själv känna känslomässigt engagemang för en text. Analysen fokuserar på de känslor “Hills Like White Elephants” förmedlar genom sin minimalistiska form. Kapitlet diskuterar den effekt formen kan ha på läsaren men snarare än att försöka slå fast vilka känslor som kan eller bör genereras menar vi att pedagogens uppgift främst är att sträva efter att ge studenterna en beredskap för att ta till sig konstverket, det vill säga, arbeta med det som Felski kallar attunement. Vi föreslår tre huvudområden att arbeta med i klassrummet för att uppnå en djupare textförståelse som i sin tur kan leda till attunement. Det första är kulturell och litterär kontext: vad behöver läsaren veta om modernismen för att förstå ”Hills Like White Elephants”? Det andra är analys av miljö, vilket inbegriper bland annat betydelsen av plats men också språkliga konstruktioner och symbolism. Slutligen diskuteras förhållandet mellan karaktärernas känslor och läsarens samt frågan om huruvida det är rimligt att ha som mål att dessa båda parter ska dela känslotillstånd.
|
|
| 2. |
- Malmstrom, Annika, et al.
(författare)
-
Gemcitabine and capecitabine in combination for advanced anthracycline and taxane pre-treated breast cancer patients: A phase II study
- 2010
-
Ingår i: ACTA ONCOLOGICA. - : Informa UK Limited. - 0284-186X .- 1651-226X. ; 49:1, s. 35-41
-
Tidskriftsartikel (refereegranskat)abstract
- Aim. The aim of this study was to explore the clinical value of gemcitabine combined with capecitabine (GC) in heavily pre-treated patients with metastatic breast cancer. Material and methods. All patients had failed anthracyclines and taxanes. In 14 patients (41%), more than two metastatic sites were diagnosed with bone (68%) and liver (62%) being the most prominent. Gemcitabine (1 250 mg/m(2), d1+8) and capecitabine (800 mg/m(2) twice daily, d1-14) were administered according to a 3-week schedule. The majority of patients received GC as 3rd or 4th line chemotherapy for metastatic disease. Laboratory tests were done on day 1+8 in cycles. Subjective toxicity was recorded according to the NCI-CTC v. 2.0 criteria. Tumour evaluations were done every 12th week according to the RECIST criteria. The primary objective was to investigate time to progression. Secondary objectives were response rate with special focus on the proportion of patients achieving PR or SD of at least three months, toxicity and survival. Results. A total of 34 patients were enrolled. All subjects are eligible for toxicity, response and time to event analyses. Treatment was given until progressive disease, severe toxicity or until the patient wanted to withdraw. The Kaplan-Meier median time to progression was estimated to 4.3 months and the overall survival time to 13.7 months. Partial response was noted in 12 of 29 evaluable patients (41%). The best outcome amongst remaining patients was stable disease in nine (31%) or tumour progression in eight (28%). A delay of disease progression of more than three months was noted in 53% of the study population. The main side effect was granulocytopenia with 44% and 15% of patients suffering from grade 3 or grade 4 events respectively however, no neutropenic infections were observed. Pre-dominant grade 3 subjective toxicities were: fatigue (21% of patients) and hand-foot syndrome (15% of patients). Discussions. We investigated the value of the GC combination as a treatment for late stage breast cancer patients. Tumour progression was delayed and the treatment was well tolerated. We believe that the GC therapy can achieve meaningful palliation.
|
|
| 3. |
- Ahlin, Gustav, et al.
(författare)
-
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1
- 2008
-
Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 51:19, s. 5932-5942
-
Tidskriftsartikel (refereegranskat)abstract
- The liver-specific organic cation transport protein (OCT1; SLC22A1) transports several cationic drugs including the antidiabetic drug metformin and the anticancer agents oxaliplatin and imatinib. In this study, we explored the chemical space of registered oral drugs with the aim of studying the inhibition pattern of OCT1 and of developing predictive computational models of OCT1 inhibition. In total, 191 structurally diverse compounds were examined in HEK293-OCT1 cells. The assay identified 47 novel inhibitors and confirmed 15 previously known inhibitors. The enrichment of OCT1 inhibitors was seen in several drug classes including antidepressants. High lipophilicity and a positive net charge were found to be the key physicochemical properties for OCT1 inhibition, whereas a high molecular dipole moment and many hydrogen bonds were negatively correlated to OCT1 inhibition. The data were used to generate OPLS-DA models for OCT1 inhibitors; the final model correctly predicted 82% of the inhibitors and 88% of the noninhibitors of the test set.
|
|
| 4. |
- Ahlin, Karin
(författare)
-
Approaching the intangible benefits of a boundary object
- 2014
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Today´s information society is constantly increasing the quantity of digital information that organisations have access to and depend on. Despite this dependency, few descriptions exist of the benefits which this digital information can provide the organisation with. Examples of what the organisation can use the information for include business intelligence or in a business process. The absence of such benefit descriptions results in missed opportunities in organisational management and a failure to cultivate the artefact. In terms of a practical operational work role, this means that the artefact just exists and that there are no decisions, communication and discussions connected to it. Earlier research about benefits in the Information Systems field is focused on describing the process of finding benefit factors from different IT investments and how these investments can be measured financially. The result of this was that it was only the measurable benefits that were taken into consideration. Later benefit management research has shown interest in the intangible benefit factors as well and added this as an activity in the evaluation process. Today´s view is that the benefit consists both of tangible and intangible benefit factors. This thesis emphasises benefit factors found by means of qualitative research in organisations producing Technical Information (TI). TI isinformation connected to goods and services and is a part of a product. The intangible benefit factors found which are connected to TI are semantic interoperability and knowledge. Semantic interoperability is beneficial both for the organisation and the individuals – in the first case exemplified by a uniform working process and in the second as efficiency in the internal communication. Knowledge also provides benefit both to the organisation and the individuals – the organisation can operate without depending on certain individuals and information gives the individuals mobility in their profession.The next part in the thesis discusses information management´simpact on benefit factors. In the case of an autocratic approach, it is the organisation that benefits most, whereas a decentralised management style provides the individual co-workers with a greater number of benefit factors. This proves that information management is an important and decisive ingredient, and that it affects benefit factors.One step in the direction of converting the intangible benefit factors into tangible ones is to visualise them. In this work the theoreticallens provided by a boundary object has been used. This lens adds a qualitative view on cross-boundary information and has efficiency approaches. These approaches are the syntactical, semantic andpragmatic. Via interpretations from the thesis´s two empirical cases, those approaches are "measured" by interpretations and visualised by the three leaves of a clover. This gives the opportunity to describewhat information efficiency, in this case connected to a positiveexpectation, can contribute to the organisation or the individuals. By this procedure, different cases or time aspects can be compared,thereby providing a basis for decision-making, communication and discussion. Future research in this area can be made in different directions – one is to investigate whether the intangible benefit factors can be turned into measurable ones. In this way, the internal organisation can be provided with better knowledge of the digital information's impact. Another research direction is to investigate how the passage of time affects the benefit factors that digital information gives the organisation.
|
|
| 5. |
- Ahlin, Karin, 1963-
(författare)
-
Benefits of Digital Technical Information
- 2020
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In our daily work life, we use a wealth of information, including a category of information produced as a part of products and their life-cycle phases, named digital technical information (DTI). Manufacturing organizations focus more often on the product than on DTI, because DTI’s impact seems almost invisible, despite its crucial role to the product and its life-cycle phases, development, production, maintenance, and destruction. Hence, the aim of this thesis is to describe DTI’s benefits and the research questions: “What are the benefits of the DTI?” and “What are the perceptions of how to measure benefits of DTI?” The thesis contains five studies related to identifying and measuring DTI’s benefits. The empirical material is based on semi-structured interviews and group interviews within five organizations and a survey among manufacturing organizations in Sweden.I used three characteristics of the DTI and two pairs of previously known benefit categories to analyse the benefits. The analysis shows that the benefits are recognized in the particular product’s life cycle phase where the DTI is published. However, the DTI continues to offer benefits in the product’s other life cycle phases. In relationship to the product, the benefits evolve from supporting an individual product to supporting more general product lines or all products and a more complex product is said to increase DTI’s benefits. DTI’s structure adds benefits as synthesized or aggregated DTI, where the DTI is synthesized or aggregated automatically or manually. The categorization predetermined benefits related to the change are less numerous than the emerging benefits. The predetermined benefits are strategic by nature, and the emerging ones are mainly used to achieve operational goals. Measuring DTI’s benefits is of importance for a formal comparison of its development and is of special interest for managers. Perceptions from the initial stages on how to measure show that to establish common interpretations among the stakeholders of the measurement process is of importance, especially when it comes to what is viewed as a benefit. The benefits are viewed as intangible by the respondents, which creates difficulties when one is evaluating, using conventional measurement methods. The only perceived way to measure is when DTI reduces co-worker’s workload and efficiency is achieved. The thesis’s contribution to academia consists of the analysis of DTI’s benefits, showing details of the relationships between the DTI and its benefits. For practice, the contributions focus on the systematic evaluation process, which can be used for further development of the DTI and comparison of the evolvement of the DTI itself and relating to other resources. One proposal for future research is to use the analysed benefits and compare various approaches to digitizing DTI, e.g. Industry 4.0. Another proposal is to list, in detail, various ways on how to measure DTI’s benefits and their usefulness. The latter can positively impact on any intangible benefits due to the general approach we have established of how to measure those benefits.
|
|
| 6. |
- Ahlin, Karin, 1963-, et al.
(författare)
-
Nyttan med CM
- 2013
-
Ingår i: Configuration Management i teknikinformationens tjänst. - Sundsvall : Mittuniversitetet.
-
Bokkapitel (populärvet., debatt m.m.)
|
|
| 7. |
|
|
| 8. |
- Ahlin, Lena
(författare)
-
Adoption och flickor : från Anne på Grönkulla till Far from the Tree
- 2022
-
Ingår i: Flickboken och flickors läsning. - Göteborg & Stockholm : Makadam Förlag. ; :164, s. 133-154
-
Bokkapitel (populärvet., debatt m.m.)abstract
- Kapitlet undersöker hur adoptioner påverkar flickors och familjemedlemmars liv utifrån L. M. Montgomerys klassiska flickbok om Anne, där adoption skildras i positiva termer och även kan kopplas till huvudpersonens självständighet och frigjordhet. Diskussionen av Anne på Grönkulla utgår från att ett critical literacy-perspektiv kan öppna en kanonisk text och göra den relevant för dagens klassrum. Frågor kring vems perspektiv som inte syns eller hörs i texten och vilka kulturella värden som texten förmedlar kan på ett produktivt sätt kopplas ihop med frågor om adoption för att analysera vilka implicita normer texten uttrycker kring exempelvis familjebildning och den samtida synen på flickor. Genom att sätta Montgomerys text i dialog med en nutida berättelse, Robin Benways Far from the Tree (2017), tydliggörs hur synen på dessa ämnen förändrats – eller inte – över tid.
|
|
| 9. |
- Ahlin, Lena
(författare)
-
Affect and nostalgia in contemporary narratives of transnational adoption
- 2018
-
Konferensbidrag (refereegranskat)abstract
- This paper focuses on contemporary Scandinavian narratives of transnational/transcultural adoption from Korea. Recently there has been a surge in primarily autobiographical publications written by adoptees themselves, such as Maja Lee Langvad’s Hun er vred (2014), Sofia French’s På jakt efter Mr. Kim i Seoul (2005), and Astrid Trotzig’s Blod är tjockare än vatten (1996). It has been pointed out that the life writing of adoptees is the most “radical” literature in Sweden today, addressing the global inequalities at the heart of transnational adoption (Svenska Dagbladet, 18 October 2015). While recognizing the progressive impetus of these texts, this paper focuses on their retrospective aspects. The texts of Langvad, French and Trotzig all center on the writer’s return to Korea; a journey that is connected to an idea of the past as holding the key to a significant part of one’s identity. To the adoptee writers, the past is literally ‘a foreign country’ and the story of this past is riddled with gaps and uncertainties reflecting the adoptee’s unknown and often unknowable origins. My analysis suggests that nostalgia in adoption literature is closely related to various figures of maternity, and that the longing for the mother is often translated into a longing for the mother country and its culture. The texts articulate intense emotions, such as melancholia, anger, and a keen sense of loss, and the paper concludes by considering the role of affect in contemporary adoption literature.
|
|
| 10. |
- Ahlin, Lena
(författare)
-
Affect and nostalgia in contemporary narratives of transnational adoption
- 2018
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This paper focuses on contemporary Scandinavian narratives of transnational/transcultural adoption from Korea. Recently there has been a surge in primarily autobiographical publications written by adoptees themselves, such as Maja Lee Langvad’s Hun er vred (2014), Sofia French’s På jakt efter Mr. Kim i Seoul (2005), and Astrid Trotzig’s Blod är tjockare än vatten (1996). It has been pointed out that the life writing of adoptees is the most “radical” literature in Sweden today, addressing the global inequalities at the heart of transnational adoption (Svenska Dagbladet, 18 October 2015). While recognizing the progressive impetus of these texts, this paper focuses on their retrospective aspects. The texts of Langvad, French and Trotzig all center on the writer’s return to Korea; a journey that is connected to an idea of the past as holding the key to a significant part of one’s identity. To the adoptee writers, the past is literally ‘a foreign country’ and the story of this past is riddled with gaps and uncertainties reflecting the adoptee’s unknown and often unknowable origins. My analysis suggests that nostalgia in adoption literature is closely related to various figures of maternity, and that the longing for the mother is often translated into a longing for the mother country and its culture. The texts articulate intense emotions, such as melancholia, anger, and a keen sense of loss, and the paper concludes by considering the role of affect in contemporary adoption literature.
|
|
