| 1. |
- Aho, Vilma, et al.
(författare)
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Partial Sleep Restriction Activates Immune Response-Related Gene Expression Pathways : Experimental and Epidemiological Studies in Humans
- 2013
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:10
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Tidskriftsartikel (refereegranskat)abstract
- Epidemiological studies have shown that short or insufficient sleep is associated with increased risk for metabolic diseases and mortality. To elucidate mechanisms behind this connection, we aimed to identify genes and pathways affected by experimentally induced, partial sleep restriction and to verify their connection to insufficient sleep at population level. The experimental design simulated sleep restriction during a working week: sleep of healthy men (N = 9) was restricted to 4 h/night for five nights. The control subjects (N = 4) spent 8 h/night in bed. Leukocyte RNA expression was analyzed at baseline, after sleep restriction, and after recovery using whole genome microarrays complemented with pathway and transcription factor analysis. Expression levels of the ten most up-regulated and ten most down-regulated transcripts were correlated with subjective assessment of insufficient sleep in a population cohort (N = 472). Experimental sleep restriction altered the expression of 117 genes. Eight of the 25 most up-regulated transcripts were related to immune function. Accordingly, fifteen of the 25 most up-regulated Gene Ontology pathways were also related to immune function, including those for B cell activation, interleukin 8 production, and NF-kappa B signaling (P<0.005). Of the ten most up-regulated genes, expression of STX16 correlated negatively with self-reported insufficient sleep in a population sample, while three other genes showed tendency for positive correlation. Of the ten most down-regulated genes, TBX21 and LGR6 correlated negatively and TGFBR3 positively with insufficient sleep. Partial sleep restriction affects the regulation of signaling pathways related to the immune system. Some of these changes appear to be long-lasting and may at least partly explain how prolonged sleep restriction can contribute to inflammation-associated pathological states, such as cardiometabolic diseases.
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| 2. |
- Aho, Vilma, et al.
(författare)
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Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses
- 2016
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on how insufficient sleep contributes to these diseases are scarce. These questions were addressed using two approaches: an experimental, partial sleep restriction study (14 cases and 7 control subjects) with objective verification of sleep amount, and two independent epidemiological cohorts (altogether 2739 individuals) with questions of sleep insufficiency. In both approaches, blood transcriptome and serum metabolome were analysed. Sleep loss decreased the expression of genes encoding cholesterol transporters and increased expression in pathways involved in inflammatory responses in both paradigms. Metabolomic analyses revealed lower circulating large HDL in the population cohorts among subjects reporting insufficient sleep, while circulating LDL decreased in the experimental sleep restriction study. These findings suggest that prolonged sleep deprivation modifies inflammatory and cholesterol pathways at the level of gene expression and serum lipoproteins, inducing changes toward potentially higher risk for cardiometabolic diseases.
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| 3. |
- Andersson, Rickard, et al.
(författare)
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Digital Corporate Communication and Internal Communication
- 2023
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Ingår i: Handbook of Digital Corporate Communication. - 978 1 80220 195 6 - 978 1 80220 196 3 ; , s. 18-33
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Bokkapitel (refereegranskat)abstract
- Internal communication is becoming increasingly digital. This chapter deals with how digital internal communication can be understood and discusses the implications of the digitalization of internal communication for organizations and organizing. It reviews previous definitions of internal communication and digitalization and proposes a definition of digital internal communication. It reviews previous studies on various aspects of digital internal communication and discusses what is changing and what remains the same as internal communication turns increasingly digital. The chapter critically examines problematic issues of the ongoing digitalization of internal communication and discusses the Swedish Transport Administration as an illustrative example of digital internal communication. It concludes with suggestions for future research directions.
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| 4. |
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| 6. |
- Johansson, Sofia, et al.
(författare)
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Digital corporate communication and hostile hijacking of organizational crises
- 2023
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Ingår i: Handbook on Digital Corporate Communication. - 978 1 80220 195 6 - 978 1 80220 196 3 ; , s. 208-221
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Bokkapitel (refereegranskat)abstract
- Social media and digital communication not only provide ways for organisations to engage stakeholders in new and more dialogic ways but have also opened a historically unprecedented Pandora’s box of disinformation techniques. Conventional crisis communication is well prepared to engage critical stakeholders, but its routines are ill-adapted to exploitative actors who employ deceptive or malicious tactics. This chapter draws attention to the ‘hostile hijacking’ of organisational crises by disinformation operators. Hostile hijacking occurs when ideologically motivated operators catalyze and amplify public outrage against organizations to make a point about the organisation’s country of origin or similar countries. Four potential tell-tale signs of a crises hijack are singled out: contribution to common disinformation narratives, logical incoherence and link by association, victimisation and mask-slipping, and conspiracy logic. The patterns are discussed and a roadmap for future directions is provided.
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| 7. |
- Simonsson, Charlotte, et al.
(författare)
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Change communication : Developing the perspective of sensemaking and the perspective of coworkers
- 2020
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Ingår i: The Handbook of Public Sector Communication. - : Wiley. - 9781119263203 - 9781119263142 ; , s. 153-166
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Bokkapitel (refereegranskat)abstract
- This chapter focuses on communication-centered change research and its implications for public sector organizations. It focuses on the organizational level and the communication processes through which changes are enacted. Special attention is given to coworkers and how they make sense in times of changes. Sensemaking processes play a crucial role in organizational changes; if managers and employees find it difficult to make sense of a current change, there will, to put it in simple terms, be no change. In effect, changes tend to trigger a process of active sensemaking among organization members. Changes are events that involve a disruption within the organization’s ongoing activities and its well-known patterns of action, which means that people actively search for meaning in change situations. The chapter highlights the complexity of changes and discusses specific prerequisites for changes in public sector organizations. Then, it discusses the vital role of sensemaking from a coworker-oriented perspective.
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