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- Kato, Norihiro, et al.
(författare)
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Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
- 2015
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 47:11, s. 1282-1293
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Tidskriftsartikel (refereegranskat)abstract
- We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10−11 to 5.0 × 10−21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10−6). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.
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- Annaduzzaman, Md., et al.
(författare)
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Tubewell platform color as a screening tool for arsenic in shallow drinking water wells in Bangladesh
- 2016
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Ingår i: Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. - : CRC Press/Balkema. - 9781138029415 ; , s. 632-633
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Konferensbidrag (refereegranskat)abstract
- The development of a simple and low cost technique for determination of arsenic (As) in drinking water wells is an urgent need to accelerate As mitigation policy. The aim of this study was to evaluate the potentiality of tubewell platform color as low-cost, quick and convenient screening tool for As. The result shows strong correlation between the development of red color stain on tubewells platform and As enrichment in the corresponding tubewells water compared to WHO (10 μg/L) and BDWS (50 μg/L), with 99% certainty. The red color stain in the platform indicates 98% sensitivity with WHO (10 μg/L) and BDWS (50 μg/L). With regard to WHO and BDWS, the corresponding efficiency of the platform color as screening tool for As are 97.3% and 97%. This study suggests that platform color can be potentially used for screening tubewells, help users switch to tube wells with low As and facilitate sustainable As mitigation efforts in developing countries.
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