| 1. |
- Albertsson, Martin, et al.
(författare)
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Calculated fission-fragment mass yields and average total kinetic energies of heavy and superheavy nuclei
- 2020
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 56:2
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Tidskriftsartikel (refereegranskat)abstract
- Fission-fragment mass and total-kinetic-energy (TKE) distributions following fission of even-even nuclides in the region 74 ≤ Z≤ 126 and 92 ≤ N≤ 230 , comprising 896 nuclides have been calculated using the Brownian shape-motion method. The emphasis is the region of superheavy nuclei. To show compatibility with earlier results the calculations are extended to include earlier studied regions. An island of asymmetric fission is obtained in the superheavy region, 106 ≤ Z≤ 114 and 162 ≤ N≤ 176 , where the heavy fragment is found to be close to 208Pb and the light fragment adjusts accordingly. Most experimentally observed α-decay chains of superheavy nuclei with Z> 113 terminate by spontaneous fission in our predicted region of asymmetric fission. In these cases, the pronounced large asymmetry is accompanied by a low TKE value compatible with measurements.
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| 2. |
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| 3. |
- Elgqvist, Jörgen, 1963, et al.
(författare)
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The Potential and Hurdles of Targeted Alpha Therapy - Clinical Trials and Beyond.
- 2014
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Ingår i: Frontiers in oncology. - : Frontiers Media SA. - 2234-943X. ; 3
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Forskningsöversikt (refereegranskat)abstract
- This article presents a general discussion on what has been achieved so far and on the possible future developments of targeted alpha (α)-particle therapy (TAT). Clinical applications and potential benefits of TAT are addressed as well as the drawbacks, such as the limited availability of relevant radionuclides. Alpha-particles have a particular advantage in targeted therapy because of their high potency and specificity. These features are due to their densely ionizing track structure and short path length. The most important consequence, and the major difference compared with the more widely used β(-)-particle emitters, is that single targeted cancer cells can be killed by self-irradiation with α-particles. Several clinical trials on TAT have been reported, completed, or are on-going: four using (213)Bi, two with (211)At, two with (225)Ac, and one with (212)Pb/(212)Bi. Important and conceptual proof-of-principle of the therapeutic advantages of α-particle therapy has come from clinical studies with (223)Ra-dichloride therapy, showing clear benefits in castration-resistant prostate cancer.
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| 4. |
- Frost, Sofia, 1981, et al.
(författare)
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Comparison of (211)At-PRIT and (211)At-RIT of Ovarian Microtumors in a Nude Mouse Model.
- 2013
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Ingår i: Cancer biotherapy & radiopharmaceuticals. - : Mary Ann Liebert Inc. - 1557-8852 .- 1084-9785. ; 28:2, s. 108-14
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Tidskriftsartikel (refereegranskat)abstract
- Abstract Purpose: Pretargeted radioimmunotherapy (PRIT) against intraperitoneal (i.p.) ovarian microtumors using avidin-conjugated monoclonal antibody MX35 (avidin-MX35) and (211)At-labeled, biotinylated, succinylated poly-l-lysine ((211)At-B-PL(suc)) was compared with conventional radioimmunotherapy (RIT) using (211)At-labeled MX35 in a nude mouse model. Methods: Mice were inoculated i.p. with 1×10(7) NIH:OVCAR-3 cells. After 3 weeks, they received PRIT (1.0 or 1.5MBq), RIT (0.9MBq), or no treatment. Concurrently, 10 additional animals were sacrificed and examined to determine disease progression at the start of therapy. Treated animals were analyzed with regard to presence of tumors and ascites (tumor-free fraction; TFF), 8 weeks after therapy. Results: Tumor status at baseline was advanced: 70% of sacrificed animals exhibited ascites. The TFFs were 0.35 (PRIT 1.0MBq), 0.45 (PRIT 1.5MBq), and 0.45 (RIT). The 1.5-MBq PRIT group exhibited lower incidence of ascites and fewer tumors >1mm than RIT-treated animals. Conclusions: PRIT was as effective as RIT with regard to TFF; however, the size distribution of tumors and presence of ascites indicated that 1.5-MBq PRIT was more efficient. Despite advanced disease in many animals at the time of treatment, PRIT demonstrated good potential to treat disseminated ovarian cancer.
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| 5. |
- Gustafsson, Anna, et al.
(författare)
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Comparison of therapeutic efficacy and biodistribution of (213)Bi- and (211)At-labeled monoclonal antibody MX35 in an ovarian cancer model.
- 2012
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Ingår i: Nuclear medicine and biology. - : Elsevier BV. - 1872-9614 .- 0969-8051. ; 39:1, s. 15-22
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: The purpose of this study was to compare the therapeutic efficacy and biodistribution of the monoclonal antibody MX35 labeled with either (213)Bi or (211)At, both α-emitters, in an ovarian cancer model. METHODS: One hundred female nude BALB/c (nu/nu) mice were inoculated intraperitoneally with human ovarian cancer cells (OVCAR-3). Two weeks later, 40 of these mice were injected intraperitoneally with ∼2.7 MBq of (213)Bi-MX35 (n=20) or ∼0.44 MBq of (211)At-MX35 (n=20). Four weeks after inoculation, 40 new OVCAR-3-inoculated mice were injected with the same activities of (213)Bi-MX35 (n=20) or (211)At-MX35 (n=20). Presence of tumors and ascites was investigated 8 weeks after therapy. Biodistributions of intraperitoneally injected (213)Bi-MX35 and (211)At-MX35 were studied in tumor-free nude BALB/c (nu/nu) mice (n=16). RESULTS: The animals injected with (213)Bi-MX35 or (211)At-MX35 2 weeks after cell inoculation had tumor-free fractions (TFFs) of 0.60 and 0.90, respectively. The untreated reference group had a TFF of 0.20. The groups treated with (213)Bi-MX35 or (211)At-MX35 4 weeks after inoculation both had TFFs of 0.25, and the reference animals all exhibited evidence of disease. The biodistributions of (213)Bi-MX35 and (211)At-MX35 were very similar to each other and displayed no alarming activity levels in the investigated organs. CONCLUSIONS: Micrometastatic growth of an ovarian cancer cell line was reduced in nude mice after treatment with (213)Bi-MX35or (211)At-MX35. Treatment with (211)At-MX35 provided a non-significantly better result for the chosen activity levels. The radiolabeled MX35 did not accumulate to a high extent in the investigated organs. No considerable signs of toxicity were observed.
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| 6. |
- Gustafsson, Joacim, et al.
(författare)
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Two new phosphate langbeinites, Rb2YbTi(PO4)(3) and Rb2Yb0.32Ti1.68(PO4)(3) investigated at 293 and 150 K
- 2005
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Ingår i: Acta Crystallographica Section C: Crystal Structure Communications. - 0108-2701 .- 1600-5759. ; 61:2, s. i9-i13
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Tidskriftsartikel (refereegranskat)abstract
- The rubidium ytterbium titanium phosphates Rb2YbTi(PO4)(3), ( I), and Rb(2)Yb(0.3)2Ti(1.68)(PO4)(3), (II), have been structurally characterized from X-ray data collected at both 293 and 150 K. Compound ( II) is blue owing to the presence of mixed-valence titanium (41% Ti3+ + 59% Ti4+). Both (I) and (II) belong to the langbeinite structure type, with mixed Yb/Ti populations in the two crystallographically independent octahedral sites ( of symmetry 3). Ytterbium favours one of these sites, where about two-thirds of the Yb atoms are found. The O-atom displacement parameters are large in both compounds at both temperatures.
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| 7. |
- Holmberg, Anna, 1974, et al.
(författare)
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Does waterborne citalopram affect the aggressive and sexual behaviour of rainbow trout and guppy?
- 2011
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Ingår i: Journal of hazardous materials. - : Elsevier BV. - 1873-3336 .- 0304-3894. ; 187:1-3, s. 596-9
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Tidskriftsartikel (refereegranskat)abstract
- Citalopram is one of several selective serotonin reuptake inhibitors (SSRIs) commonly found in treated sewage effluents. Accordingly, there are concerns about possible adverse effects of SSRIs on aquatic organisms, particularly behavioural effects similar to those associated with SSRI use in humans. Rainbow trout fry and adult male guppies were therefore exposed to waterborne citalopram, ranging from environmentally relevant to high concentrations (1, 10, 100 μg/L) for 3-7 days. Under these experimental conditions citalopram does not appear to cause significant effects on aggression in rainbow trout fry or on sexual behaviour in male guppies. This may be explained by a relatively low uptake of citalopram from water to fish.
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| 8. |
- Norberg, Stefan, 1972, et al.
(författare)
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A TiP2O7 superstructure
- 2001
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Ingår i: Acta Crystallographica Section C: Crystal Structure Communications. - 0108-2701 .- 1600-5759. ; 57:3, s. 225-227
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Tidskriftsartikel (refereegranskat)abstract
- A room-temperature structural model of titanium pyrophosphate, TiP2O7, has been determined from synchrotron X-ray data. The structure consists of TiO6 octahedra and PO4 tetrahedra sharing corners in a three-dimensional network. The PO4 tetrahedra form P2O7 groups connecting the TiO6 octahedra. The 3 x 3 x 3 superstructure differs substantially from the parent AB(2)O(7) structure. The P-O-P bonding angles of the pyrophosphate group are between 141.21 (12) and 144.51 (13)degrees for those groups not located on the threefold axis. The individual TiO6 octahedra and PO4 tetrahedra are somewhat distorted.
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| 9. |
- Norberg, Stefan, 1972, et al.
(författare)
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Dopant positions in strontium/chromium- and barium-doped KTP, determined with synchrotron X-radiation
- 2001
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Ingår i: Acta Crystallographica Section B: Structural Science. - 0108-7681 .- 1600-5740. ; 56:6, s. 980-987
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Tidskriftsartikel (refereegranskat)abstract
- Structure factors for strontium/chromium- (Sr/Cr) and barium- (Ba) doped potassium titanyl phosphate (KTiOPO4, KTP) were measured with focused synchrotron X-radiation [0.75000 (9) Angstrom] using a fast avalanche photodiode counter. Space group Pna2(1), Z = 8,a = 12.786 (2), b = 6.3927 (8), c = 10.5585 (9) Angstrom, T = 293 (1) K, R = 0.028 (SrCrKTP); a = 12.851 (6), b = 6.418 (3), c = 10.620 (5) Angstrom, T = 120 (1) K, R = 0.031 (BaKTP). The refinement of the dopant positions showed that Ba2+ is positioned in the larger of the two K cavities of KTP, while the smaller Sr2+ ion is located in both. Split positions are found for the strontium dopant in both cavities and they are located in the positive c direction from the potassium cation. The chromium dopant has two different oxidation states, namely +III and +VI; in both states the dopant is located inside the TiO6 octahedra. The two structures show slightly less distorted TiO6 octahedra than pure KTP.
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| 10. |
- Norberg, Stefan, 1972, et al.
(författare)
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KSbO(Ge0.32Si0.68)O-4, a KTP isomorph
- 2001
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Ingår i: Acta Crystallographica Section C: Crystal Structure Communications. - 0108-2701 .- 1600-5759. ; 57:5, s. 510-512
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Tidskriftsartikel (refereegranskat)abstract
- A structural model of potassium antimony germanate/silicate (0.32/0.68), KSbO(Ge0.32Si0.68)O-4, has been determined at room temperature. KSbO(Ge0.32Si0.68)O-4 belongs to the KTiOPO4 (KTP) isomorphic family and is composed of SbO6 octahedra (site symmetry (1) over bar and 2) arranged in helical chains bridged by (Ge/Si)O-4 tetrahedra. Germanium and silicon have a similar distribution in the crystallographically independent tetrahedra (site symmetry 2). The structure contains large cavities occupied by the K atom. Two partially occupied potassium positions have been identified 1.273 (8) Angstrom apart, with an indication of a third potassium position between them. At room temperature, KSbO(Ge0.32Si0.68)O-4 crystallizes in the paraelectric phase of space group Pnan. This phase is found at elevated temperatures for almost all KTiOPO4 isomorphic compounds and KSbO(Ge0.32Si0.68)O-4 is the second isomorph that is paraelectric at room temperature.
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