| 1. |
- Abbadessa, G, et al.
(författare)
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Unsung hero Robert C. Gallo
- 2009
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 323:5911, s. 206-207
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Albini, A, et al.
(författare)
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Oncogenesis in HIV-infection
- 1996
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Ingår i: International journal of oncology. - 1019-6439. ; 9:1, s. 5-8
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Coulibaly, S, et al.
(författare)
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Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C
- 1999
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Ingår i: International Journal of Cancer. - 0020-7136. ; 83:4, s. 526-531
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Tidskriftsartikel (refereegranskat)abstract
- Murine SCC-VII squamous carcinoma cells have the capacity to penetrate reconstituted basement membranes (Matrigel) in vitro. The invasion of Matrigel layers by SCC-VII cells was significantly reduced by E-64, a specific inhibitor of lysosomal cysteine proteinases. The cathepsin-B-selective E-64 derivative, CA-074, inhibited penetration of Matrigel by SCC-VII cells to the same extent, indicating a major role for this particular lysosomal enzyme in extracellular-matrix degradation during squamous-carcinoma-cell invasion. SCC-VII cells were stably transfected with a cDNA encoding human procathepsin B, in an attempt to modulate the invasive properties of the cell line. The transfected cells expressed the heterologous gene, secreted increased amounts of procathepsin B and displayed enhanced invasive potential. In vivo, the activity of cathepsin B is strictly regulated by endogenous inhibitors. SCC-VII cells were therefore also stably transfected with a cDNA encoding human cystatin C, the most potent cysteine-proteinase inhibitor in mammalian tissues. The expression of this transgene resulted in the production of active recombinant cystatin C and a pronounced reduction in Matrigel invasion. These studies demonstrate that the invasive properties of squamous-cell carcinomas can be changed by modulation of the balance between cathepsin B and its endogenous inhibitors, and provide further evidence for the involvement of this lysosomal cysteine proteinase in tumour invasion and metastasis.
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| 4. |
- Georgoulas, George, 1976-, et al.
(författare)
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An Automatic Method for Condition Monitoring of Inverter Fed Induction Motors
- 2018
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Ingår i: Proceedings. - : IEEE. ; , s. 1754-1760
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Konferensbidrag (refereegranskat)abstract
- This paper proposes an automatic method, for monitoring inverter fed induction motors using external stray flux measurements. The method relies on the marginal power spectrum of the Synchrosqueezed Wavelet Transform for the feature extraction stage and on Principal Component Analysis for the reduction of the high dimensionality of the generated feature vector. For the next stage two approaches were tested: a) a fault detector based on a one-class classifier and b) a fault diagnosis module based on a multiclass classifier. Both of them achieve high accuracies when tested with measurements coming from an experimental set up able to simulate stator short circuits and bearing faults. An explanation of the performance is given by visual inspection of the projection of the feature vectors into a three-dimensional space.
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