| 1. |
- Alcaraz Martinez, Raul, et al.
(författare)
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Application of frequency and sample entropy to discriminate long-term recordings of paroxysmal and persistent atrial fibrillation
- 2010
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Ingår i: Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE. - 1557-170X. - 9781424441235 ; , s. 4558-4561
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Konferensbidrag (refereegranskat)abstract
- Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. At an early stage of the disease, AF may terminate spontaneously and is then referred to as paroxysmal AF. On the other hand, when external intervention is required for the arrhythmia to terminate, it is referred to as persistent AF. In this work, a method to discriminate between paroxysmal and persistent AF in the long-term ECGs is presented. The dominant frequency as well as the organization of the atrial activity are employed to characterize AF. The dominant atrial frequency (DAF) is estimated using hidden Markov model based frequency tracking, and organization is estimated by the sample entropy of the main atrial wave (MAW) and the first two harmonics, respectively. Long-term variations in DAF and organization from 50 ECG recordings were evaluated, showing that episodes of paroxysmal AF were consistently associated with lower DAF and organization of the MAW and the harmonics, than was persistent AF. Discrimination of paroxysmal and persistent AF resulted in classification rates of 84.1±26.1%, thus suggesting that it possible to discriminate between paroxysmal and persistent AF in patients without previously known AF history.
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| 2. |
- Alcaraz Martinez, Raul, et al.
(författare)
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Classification of paroxysmal and persistent atrial fibrillation in ambulatory ECG recordings
- 2011
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Ingår i: IEEE Transactions on Biomedical Engineering. - 1558-2531. ; 58, s. 1441-1449
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Tidskriftsartikel (refereegranskat)abstract
- The problem of classifying short atrial fibrillatory segments in ambulatory ECG recordings as being either paroxysmal or persistent is addressed by investigating a robust approach to signal characterization. The method comprises preprocessing, estimation of the dominant atrial frequency for the purpose of controlling the subbands of a filter bank, and computation of the relative subband (harmonics) energy and the subband sample entropy. Using minimum-error-rate classification of different feature vectors, a dataset consisting of 24-h ambulatory recordings from 50 subjects with either paroxysmal (26) or persistent (24) atrial fibrillation (AF) was analyzed on a 10-s segment basis; a total of 212196 segments were classified. The best performance in terms of area under the receiver operating characteristic curve was obtained for a feature vector defined by the subband sample entropy of the dominant atrial frequency and the relative harmonics energy, resulting in a value of 0.923, whereas that of the dominant atrial frequency was equal to 0.826. It is concluded that paroxysmal and persistent AF can be discriminated from short segments with good accuracy at any time of an ambulatory recording.
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| 3. |
- Tiraboschi, Juan M, et al.
(författare)
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No changes in HIV suppression and inflammatory markers in CSF in patients randomly switched to DTG + 3TC (Spanish HIV/AIDS Research Network, PreEC/RIS 62).
- 2021
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Ingår i: The Journal of infectious diseases. - : Oxford University Press (OUP). - 1537-6613 .- 0022-1899. ; 223:11, s. 1928-1933
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Tidskriftsartikel (refereegranskat)abstract
- A major concern of HIV dual therapy is a potential lower efficacy in viral reservoirs, especially in the central nervous system (CNS). We evaluated HIV RNA, neuronal injury and inflammatory biomarkers and dolutegravir (DTG) exposure in cerebrospinal fluid (CSF) in patients switching to DTG+lamivudine (3TC). All participants maintained viral suppression in plasma and CSF at week 48. We observed no increase in CSF markers of inflammation or neuronal injury. Median (IQR) total and unbound DTG in CSF were 7.3(5.9-8.4) ng/mL and 1.7(1.2-1.9) ng/mL, respectively. DTG+3TC may maintain viral control without changes in inflammatory/injury markers within the CNS reservoir.
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