| 1. |
- Ferrando, Carlos, et al.
(författare)
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Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy : a randomised controlled trial
- 2020
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Ingår i: British Journal of Anaesthesia. - : ELSEVIER SCI LTD. - 0007-0912 .- 1471-6771. ; 124:1, s. 110-120
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Tidskriftsartikel (refereegranskat)abstract
- Background: We aimed to examine whether using a high fraction of inspired oxygen (FIO2) in the context of an individualised intra- and postoperative open-lung ventilation approach could decrease surgical site infection (SSI) in patients scheduled for abdominal surgery. Methods: We performed a multicentre, randomised controlled clinical trial in a network of 21 university hospitals from June 6, 2017 to July 19, 2018. Patients undergoing abdominal surgery were randomly assigned to receive a high (0.80) or conventional (0.3) FIO2 during the intraoperative period and during the first 3 postoperative hours. All patients were mechanically ventilated with an open-lung strategy, which included recruitment manoeuvres and individualised positive end-expiratory pressure for the best respiratory-system compliance, and individualised continuous postoperative airway pressure for adequate peripheral oxyhaemoglobin saturation. The primary outcome was the prevalence of SSI within the first 7 postoperative days. The secondary outcomes were composites of systemic complications, length of intensive care and hospital stay, and 6-month mortality. Results: We enrolled 740 subjects: 371 in the high FIO2 group and 369 in the low FIO2 group. Data from 717 subjects were available for final analysis. The rate of SSI during the first postoperative week did not differ between high (8.9%) and low (9.4%) FIO2 groups (relative risk [RR]: 0.94; 95% confidence interval [CI]: 0.59-1.50; P=0.90]). Secondary outcomes, such as atelectasis (7.7% vs 9.8%; RR: 0.77; 95% CI: 0.48-1.25; P=0.38) and myocardial ischaemia (0.6% [n=2] vs 0% [n=0]; P=0.47) did not differ between groups. Conclusions: An oxygenation strategy using high FIO2 compared with conventional FIO2 did not reduce postoperative SSIs in abdominal surgery. No differences in secondary outcomes or adverse events were found.
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| 2. |
- Aharony, Ofer, et al.
(författare)
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The analytic bootstrap for large N Chern-Simons vector models
- 2018
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Ingår i: Journal of High Energy Physics (JHEP). - 1126-6708 .- 1029-8479. ; :8
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Tidskriftsartikel (refereegranskat)abstract
- Three-dimensional Chern-Simons vector models display an approximate higher spin symmetry in the large N limit. Their single-trace operators consist of a tower of weakly broken currents, as well as a scalar a of approximate twist 1 or 2. We study the consequences of crossing symmetry for the four-point correlator of a in a 1/N expansion, using analytic bootstrap techniques. To order 1/N we show that crossing symmetry fixes the contribution from the tower of currents, providing an alternative derivation of well-known results by Maldacena and Zhiboedov. When sigma has twist 1 its OPE receives a contribution from the exchange of a itself with an arbitrary coefficient, due to the existence of a marginal sextic coupling. We develop the machinery to determine the corrections to the OPE data of double-trace operators due to this, and to similar exchanges. This in turns allows us to fix completely the correlator up to three known truncated solutions to crossing. We then proceed to study the problem to order 1/N-2. We find that crossing implies the appearance of odd-twist double-trace operators, and calculate their OPE coefficients in a large spin expansion. Also, surprisingly, crossing at order 1/N-2, implies non-trivial O(1/N) anomalous dimensions for even-twist double-trace operators, even though such contributions do not appear in the four-point function at order 1/N (in the case where there is no scalar exchange). We argue that this phenomenon arises due to operator mixing. Finally, we analyse the bosonic vector model with a sextic coupling without gauge interactions, and determine the order 1/N-2 corrections to the dimensions of twist-2 double-trace operators.
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| 3. |
- Alday, Luis F., et al.
(författare)
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Genus-One String Amplitudes from Conformal Field Theory
- 2019
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Ingår i: Journal of High Energy Physics (JHEP). - 1126-6708 .- 1029-8479. ; :6
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Tidskriftsartikel (refereegranskat)abstract
- We explore and exploit the relation between non-planar correlators in N=4 super-Yang-Mills, and higher-genus closed string amplitudes in type IIB string theory. By conformal field theory techniques we construct the genus-one, four-point string amplitude in AdS5×S5 in the low-energy expansion, dual to an N=4 super-Yang-Mills correlator in the 't Hooft limit at order 1/c2 in a strong coupling expansion. In the flat space limit, this maps onto the genus-one, four-point scattering amplitude for type II closed strings in ten dimensions. Using this approach we reproduce several results obtained via string perturbation theory. We also demonstrate a novel mechanism to fix subleading terms in the flat space limit of AdS amplitudes by using string/M-theory.
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| 4. |
- Alday, Luis F., et al.
(författare)
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One-loop gluon amplitudes in AdS
- 2022
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Ingår i: Journal of High Energy Physics (JHEP). - : Springer Nature. - 1126-6708 .- 1029-8479. ; :2
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Tidskriftsartikel (refereegranskat)abstract
- We initiate the study of one-loop gluon amplitudes in AdS space. These amplitudes were recently computed at tree level for a variety of backgrounds of the form AdS(d+1) x S-3. For concreteness, we compute the one-loop correction to the massless gluon amplitude on AdS(5) x S-3, which corresponds to the four-point correlator of the flavor current multiplet in the dual 4d N = 2 SCFT. This requires solving a mixing problem that involves tree-level amplitudes of arbitrarily massive Kaluza-Klein modes. The final answer has the same color structure as in flat space but the dependence on Mandelstam variables is more complicated, with logarithms replaced by polygamma functions.
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