| 1. |
- Coles, J. B., et al.
(författare)
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Bandwidth-efficient phase modulation techniques for Stimulated Brillouin Scattering suppression in fiber optic parametric amplifiers
- 2010
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Ingår i: Optics Express. - 1094-4087 .- 1094-4087. ; 18:17, s. 18138-18150
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Tidskriftsartikel (refereegranskat)abstract
- Two novel bandwidth efficient pump-dithering Stimulated Brillouin Scattering (SBS) suppression techniques are introduced. The techniques employ a frequency-hopped chirp and an RF noise source to impart phase modulation on the pumps of a two pump Fiber Optical Parametric Amplifier (FOPA). The effectiveness of the introduced techniques is confirmed by measurements of the SBS threshold increase and the associated improvements relative to the current state of the art. Additionally, the effect on the idler signal integrity is presented as measured following amplification from a two pump FOPA employing both techniques. The measured 0.8 dB penalty with pumps dithered by an RF noise source, after accruing 160ps/nm of dispersion with 38 dB conversion gain in a two-pump FOPA is the lowest reported to date.
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| 2. |
- Myslivets, E., et al.
(författare)
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Dispersion Fluctuation Equalization Nonlinear Fibers by Spatially Controlled Tension
- 2010
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Ingår i: Optical Fiber Communication Conference, OFC 2010; San Diego, CA; United States; 21 March 2010 through 25 March 2010. - 2162-2701. - 9781557528841
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Konferensbidrag (refereegranskat)abstract
- We experimentally verified that spatial dispersive fluctuations in nonlinear fiber can be effectively suppressedby inverting precisely mapped zero-dispersion wavelength via application of longitudinally controlled stretching.
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| 3. |
- Myslivets, E., et al.
(författare)
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Spatial Equalization of Zero-Dispersion Wavelength Profiles in Nonlinear Fibers
- 2009
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Ingår i: IEEE Photonics Technology Letters. - 1041-1135 .- 1941-0174. ; 21:24, s. 1807-1809
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Tidskriftsartikel (refereegranskat)abstract
- Longitudinal zero-dispersion wavelength (ZDW) fluctuations in long waveguides impose a fundamental limit on the achievable parametric mixer bandwidth. We demonstrate for the first time that the precisely measured ZDW profile can be taken advantage of by applying spatially controlled tension along the fiber length for fluctuation reduction and synthesis of a wide mixer response. The technique was experimentally validated by measuring local dispersion and tension maps and synthesizing a 145-nm-wide fiber parametric amplifier.
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| 4. |
- Alic, I., et al.
(författare)
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Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain
- 2021
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Ingår i: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 26:10, s. 5766-5788
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Tidskriftsartikel (refereegranskat)abstract
- A population of more than six million people worldwide at high risk of Alzheimer's disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom develop dementia during lifetime, caused by an extra copy of beta-amyloid-(A beta)-precursor-protein gene. We report AD-like pathology in cerebral organoids grown in vitro from non-invasively sampled strands of hair from 71% of DS donors. The pathology consisted of extracellular diffuse and fibrillar A beta deposits, hyperphosphorylated/pathologically conformed Tau, and premature neuronal loss. Presence/absence of AD-like pathology was donor-specific (reproducible between individual organoids/iPSC lines/experiments). Pathology could be triggered in pathology-negative T21 organoids by CRISPR/Cas9-mediated elimination of the third copy of chromosome 21 gene BACE2, but prevented by combined chemical beta and gamma-secretase inhibition. We found that T21 organoids secrete increased proportions of A beta-preventing (A beta 1-19) and A beta-degradation products (A beta 1-20 and A beta 1-34). We show these profiles mirror in cerebrospinal fluid of people with DS. We demonstrate that this protective mechanism is mediated by BACE2-trisomy and cross-inhibited by clinically trialled BACE1 inhibitors. Combined, our data prove the physiological role of BACE2 as a dose-sensitive AD-suppressor gene, potentially explaining the dementia delay in similar to 30% of people with DS. We also show that DS cerebral organoids could be explored as pre-morbid AD-risk population detector and a system for hypothesis-free drug screens as well as identification of natural suppressor genes for neurodegenerative diseases.
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| 5. |
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| 6. |
- Myslivets, E., et al.
(författare)
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1.56-μs continuously tunable parametric delay line for a 40-Gb/s signal
- 2009
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Ingår i: Optics Express. - 1094-4087 .- 1094-4087. ; 17:14, s. 11958-11964
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Tidskriftsartikel (refereegranskat)abstract
- Experimental demonstration of an all-fiber, all-optical continuously tunable delay line is reported. The 1.56-mu s delay with a record 62,400 time-delay bit-rate product was characterized for a 40-Gbps data channel. The result was enabled by parametric dispersion compensation with cascaded triple-conversion in highly-nonlinear fiber capable of continuous tuning over 39.5 nm.
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| 7. |
- Alic, N., et al.
(författare)
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Benefits of Joint Statistics in MLSD-Equalized Transmission
- 2009
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Ingår i: IEEE Photonics Technology Letters. - 1041-1135 .- 1941-0174. ; 21:8, s. 495-497
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Tidskriftsartikel (refereegranskat)abstract
- We experimentally investigate and quantify performance improvement, accounting for multiple bit intervals' joint statistics in filtered equalized on-off keying OC-192 fiber-optic links relying on Viterbi-algorithm-based sequence detection. We demonstrate that the penalty associated with narrow filtering can be alleviated for the most part with an appropriate detection approach.
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| 8. |
- Alic, N., et al.
(författare)
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Joint Statistics and MLSD in Filtered Incoherent High-Speed Fiber-Optic Communications
- 2010
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Ingår i: Journal of Lightwave Technology. - 0733-8724 .- 1558-2213. ; 28:10, s. 1564-1572
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, signal statistics and their utilization for detection in narrowly filtered equalized high-speed fiber-optic communications are investigated experimentally. Tradeoffs between log-likelihood metric applications and oversampling are covered in detail. It is, for the first time, demonstrated that performance loss in bandwidth-limited systems can be nearly fully recovered (to within 0.5 dB) by taking advantage of band-width-limitation-induced noise correlations and oversampling.
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| 9. |
- Alisic, E., et al.
(författare)
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The Role of an Assistant Nurse in Implementing the WHO Surgical Safety Checklist: Perception and Perspectives
- 2023
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Ingår i: Cureus Journal of Medical Science. - 2168-8184. ; 15:5
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Tidskriftsartikel (refereegranskat)abstract
- Introduction The World Health Organization (WHO) Surgical Safety Checklist is a tool developed by the WHO to promote safer surgical practices and reduce the incidence of surgical errors and complications. This study aims to describe the role of assistant nurses in the implementation of this checklist by surgical teams. Materials and methods This descriptive study utilized a questionnaire-based survey conducted between September 2018 and March 2019 among 196 healthcare professionals at two surgical units in a university hospital in Sweden. The questionnaire covered demographic information such as age, gender, and occupation, as well as details about their workplace, experience, education/training on using the WHO checklist, the adaptation of the checklist to their department, their responsibilities in implementing and using the checklist, the frequency of use in emergency situations, and the impact on patient safety. Results The results of the study showed that assistant nurses, despite having the lowest level of education among healthcare professionals, were highly trusted and valued by other members of the surgical team. Most healthcare professionals were unsure who was responsible for using the WHO checklist but believed it was the assistant nurse's responsibility to ensure its implementation. Assistant nurses reported little to no training on using the checklist but noted that it had been adapted to the department's needs. Almost half (48.8%) of assistant nurses believed that the checklist was often used in emergency surgery, and most believed that it improved patient safety. Conclusions Improved understanding of the significance of assistant nurses in implementing the WHO Surgical Safety Checklist may enhance adherence to the checklist and potentially improve patient safety, as they were the most valued and trusted healthcare professionals in the surgical team according to the study's findings.
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| 10. |
- Grbic, K., et al.
(författare)
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The impact of social environment and educational level on public knowledge and attitudes towards organ donation: Can we do better?
- 2022
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Ingår i: Annali Di Igiene Medicina Preventiva E Di Comunita. - 1120-9135. ; 34:5, s. 453-466
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Tidskriftsartikel (refereegranskat)abstract
- Background. For many patients with end-stage disease, organ transplant often provides the only chance for survival. Organ donation (OD) is affected by legislation, cultural and ethnic background, and knowledge and attitudes play a crucial role in promoting that concept. The present study aimed to assess differences in education level, perception, and willingness towards OD among Bosnian immigrants living in Sweden and respondents living in Bosnia and Herzegovina. Study design. We performed a quantitative cross-sectional study using a self-administered questionnaire among 204 participants. Methods. The questionnaire provided demographic characteristics, information about opinions, awareness, and knowledge on the donation process and religious approach to the subject, willingness to donate/receive organs, and possession of a donor card. Results. All respondents supported OD, regardless of their education level. Only 2% of university-educated individuals from Bosnia and Herzegovina claimed to be donor card owners (p<0.001). Most of the university-educated respondents in Sweden, compared to Bosnia and Herzegovina, agreed that OD is needed and should be promoted (73.8% vs. 46.9%, p=0.007), opposite to the non-university-educated (51.4% vs. 66.0%, p=0.024). University-educated respondents stated that the donor card was informative enough (p=0.014) and considered self-perceived knowledge about OD to be sufficient or excellent (p<0.001). Most respondents were married and employed, practicing Muslims. Most of non-university-educated respondents from both countries believe their religion does not oppose OD (p=0.032). However, university-educated individuals strongly believe that OD does not have to be within the same religious group (p=0.016), while other participants did not have a definitive opinion. Conclusions. Public behavior towards OD is affected by the social environment and the educational level. The study highlights the importance of achieving a suitable social climate for donation. Also, it suggests that more efforts are needed to harvest the benefits of the substantial support for OD among the Bosnian population.
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