| 1. |
- Almqvist, Bjarne, et al.
(författare)
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Magnetic characterisation of magnetite and hematite from the Blötberget apatite-iron-oxide deposits (Bergslagen), south-central Sweden
- 2019
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Ingår i: Canadian journal of earth sciences (Print). - : Canadian Science Publishing. - 0008-4077 .- 1480-3313. ; 56:9, s. 948-957
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Tidskriftsartikel (refereegranskat)abstract
- Rock magnetic measurements were carried out on drill core material and hand specimens from the Blötberget apatite-iron oxide deposit in the Bergslagen ore province, south-central Sweden, to characterise their magnetic properties. Measurements included several kinds of magnetic susceptibility and hysteresis parameters. Petrographic and scanning electron microscopy (SEM) were used to independently identify and quantify the amount and type of magnetite and hematite. Two hematite-rich samples were studied with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) to quantify the trace element chemistry in hematite and investigate the potential influence of trace elements on magnetic properties. Three aspects of this study are noteworthy. 1) Hematite-rich samples display strong anisotropy of magnetic susceptibility, which is likely to affect the appearance and modelling of magnetic anomalies. 2) The magnitude-drop in susceptibility across Curie and Néel temperature transitions show significant correlation with the respective weight percent (wt%) of magnetite and hematite. Temperature dependent magnetic susceptibility measurements can therefore be used to infer the amounts of both magnetite and hematite. 3) observations of a strongly depressed Morin transition at ca -60 to -70 C (200 to 210 K) are made during low-temperature susceptibility measurements. This anomalous Morin transition is most likely related to trace amounts of V and Ti that substitute for Fe in the hematite. When taken together, these magnetic observations improve the understanding of the magnetic anomaly signature of the Blötberget apatite-iron oxide deposits and may potentially be utilised in a broader context when assessing similar (Paleoproterozoic) apatite-iron oxide systems.
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| 2. |
- Almqvist, Daniel, et al.
(författare)
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Strategies for a safe interhospital transfer with an intubated patient or where readiness for intubation is needed: A critical incidents study
- 2023
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Ingår i: Intensive & Critical Care Nursing. - : Elsevier. - 0964-3397 .- 1532-4036. ; 74
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: The number of interhospital transports with intubated patients or where intubation readiness is required is increasing in Sweden and globally. Specialist nurses are often responsible for these transports, which involve numerous risks for critically ill patients.Aim: The aim of this study was to describe nurse anaesthetists’ and intensive care nurses’ strategies for safe interhospital transports with intubated patients or where intubation readiness is required.Method: A qualitative study was conducted using the critical incident technique. During March and April 2020, 12 semi-structured interviews were conducted with nurse anaesthetists and intensive care nurses. Data were analysed according to the critical incident technique, and a total of 197 critical incidents were identified. The analysis revealed five final strategies for safe interhospital transport.Results: Participants described the importance of ensuring clear and adequate information transfers between caregivers to obtain vital patient information that enables the nurse in charge to identify risks and problems in advance and create an action plan. Stabilising and optimising the patient's condition before departure and preparing drugs and equipment were other strategies described by the participants, as well as requesting assistance or support if questions or complications arose during transport.Conclusion: Transports with intubated patients or where intubation readiness is required are complex and require systematic patient-safety work to ensure that strategies for increasing patient safety and decreasing risks are visible to the nurses in charge, that they are applied, and that they are, indeed, effective.
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| 3. |
- Almqvist, Erik, et al.
(författare)
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Solving the ADAPT Benchmark Problem - A Student Project Study
- 2010
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Konferensbidrag (refereegranskat)abstract
- This paper describes a solution to the Advanced Diagnosis and Prognostics testbed (ADAPT) diagnosis benchmark problem. One main objective was to study and discuss how engineering students, with no diagnosis research background, would solve a challenging diagnosis problem. The study was performed within the framework of a final year project course for control engineering students. A main contribution of the work is the discussion on the development process used by the students. The solution is based on physical models of components and includes common techniques from control theory, like observers and parameter estimators, together with established algorithms for consistency based fault isolation. The system is fully implemented in C++ and evaluated, using the DXC software platform, with good diagnosis performance.
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| 4. |
- Almqvist, Gustaf, et al.
(författare)
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Report of the Benchmark Workshop on Baltic Cod Stocks (WKBALTCOD)
- 2015
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The ICES Benchmark Workshop on Baltic Cod Stocks (WKBALTCOD), chaired by External Chair Jean-Jacques Maguire, Canada and ICES Chair Marie Storr-Paulsen, Denmark, and attended by two invited external experts Verena Trenkel, France and Meaghan Bryan, USA met in Rostock, Germany, 2–6 March 2015 with 39 participants and six countries represented. The objective of WKBALTCOD was to evaluate the appropriateness of data and methods to determine stock status and investigate meth-ods appropriate to use in the single-stock assessment for the cod stock in SD 22–24 and cod in SD 25–32 in the Baltic. Participants in the workshop were a large group with diverse backgrounds representing the industry, fisheries, NGOs, managers and scientists.The single-stock analytic assessment of the eastern Baltic stock was not accepted by the assessment working group (WGBFAS) in 2014 due to severe problems with the input data. The advice for the eastern Baltic cod was, therefore, based on the ICES approach for data-limited stocks. As an outcome ICES decided to establish a bench-mark for both cod stocks and to scope an integrated assessment for the Baltic cod stocks. The first meeting (WKSIBCA) was therefore meant to introduce the interces-sional work conducted since the assessment working group in April 2014, and to reach some conclusions on how to proceed both in the short term (Benchmark in March 2015) and longer term (2–3 years) and was seen as a data compilation work-shop, there is produced a separate report from this workshop. The WKBALTCOD was the 2nd meeting in the benchmark process and was intended to come up with a final stock assessment method, stock annex and input data for both stocks. As it was not possible to reach conclusive decision on the final model to be used for the east Baltic cod stock during the benchmark meeting and as more work on the preferable models was needed, it was decided by the ACOM leadership to prolong the bench-mark process until the assessment working group meeting in April 2015. This deci-sion has led to a relatively long process partly mixed with the assessment working group WGBFAS.It became clear during the benchmark process that although large effort has been put into explaining the underlying processes leading to the changes in the Baltic ecosys-tem, there is still some lack of understanding of the present situation in the eastern Baltic cod stock. Therefore, it was not possible to reach firm conclusions on the final model to be used and therefore not possible to set reference points. It was decided to continue to explore the most promising models and to continue to improve the input data until the assessment working group started in April.The main challenges still to be solved for the Eastern Baltic cod stock is the quantifi-cation of increased natural mortality and decrease in growth. Through several presentations during the workshop (both WKSIBCA and WKBALTCOD) it became clear that natural mortality very likely has increased in later years, due to decreased condition and increased parasite infection. A decrease in growth also seems plausible duo to a decrease in condition and/or selectivity-induced mortality of the largest in-dividuals. However, as none of these parameters are easily estimated, especially with the severe ageing problems, different model assumptions made the output very shaky.For the western Baltic cod, stock identification issues were examined in area SD 24, the intermediate area: based on otolith characteristics and genetics. Due to the results showing a large proportion of east cod in this area, it was decided to split the catch2 | ICES WKBALTCOD REPORT 2015and survey from SD 24 into either the western or eastern Baltic cod stock. It was pos-sible to derive proportions of eastern and western cod in SD 24 back to the mid-1990s.For the western Baltic cod stock a modelled survey indices was included in the as-sessment covering the western part of SD 24 and Area 22+23 and based on a smoothed ALK.Both cod stocks have in the past used commercial tuning fleet to have a better cov-ered of older age groups. It was decided to abound this time-series duo quality issues such as a limited coverage and problems with technical creeping.WKBALTCOD was not able to explore and define reference points for the Western Baltic cod stock during the meeting due to time constraints, but these were calculated and decided by correspondence after the meeting. The recent protocols on estimation procedures developed by WKMSYREF3 for stocks with a full analytical assessment and for data-limited stocks served as objective guidelines to obtain reference point estimates.
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| 5. |
- Almqvist, Helena, et al.
(författare)
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CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
- 2016
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Target engagement is a critical factor for therapeutic efficacy. Assessment of compound binding to native target proteins in live cells is therefore highly desirable in all stages of drug discovery. We report here the first compound library screen based on biophysical measurements of intracellular target binding, exemplified by human thymidylate synthase (TS). The screen selected accurately for all the tested known drugs acting on TS. We also identified TS inhibitors with novel chemistry and marketed drugs that were not previously known to target TS, including the DNA methyltransferase inhibitor decitabine. By following the cellular uptake and enzymatic conversion of known drugs we correlated the appearance of active metabolites over time with intracellular target engagement. These data distinguished a much slower activation of 5-fluorouracil when compared with nucleoside-based drugs. The approach establishes efficient means to associate drug uptake and activation with target binding during drug discovery.
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| 6. |
- Almqvist, Kjerstin, et al.
(författare)
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Psykisk ohälsa
- 2005
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Rapport (refereegranskat)
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| 7. |
- Almqvist, Nils, et al.
(författare)
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Methods for fabricating and characterizing a new generation of biomimetic materials
- 1999
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Ingår i: Materials science & engineering. C, biomimetic materials, sensors and systems. - 0928-4931 .- 1873-0191. ; 7:1, s. 37-43
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Tidskriftsartikel (refereegranskat)abstract
- Bringing together current ideas in the fields of biomineralization and composite laminate materials, we have attempted to fabricate model materials that mimic abalone nacre through the rapid assembly of inorganic tablets, such as talc. Several physical methods were tested to aid the orientation of the talc tablets in fluid suspensions with a low percentage, 10% by dry weight, of organic binding material. The orientation of talc tablets in the synthesized composites was characterized by X-ray diffraction and scanning electron microscopy. The modulus of rupture of the materials was measured in a three-point bending test. We demonstrate that the alignment of tablets increases by the use of physical methods and from chemical surface treatment. Important factors to consider in making materials that mimic abalone nacre are discussed. Important factors to consider in making materials that mimic abalone nacre are discussed.
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| 8. |
- Bergh, Daniel, et al.
(författare)
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Sociala relationer och ohälsa
- 2005
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Ingår i: I Kalander Blomqvist, M & Janson, S (red), Värmlänningarnas liv och hälsa 2004. - Karlstad : Landstinget i Värmland och Karlstads universitet. ; , s. 118-125
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Ferreira, Daniel, et al.
(författare)
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Brain changes in Alzheimer's disease patients with implanted encapsulated cells releasing nerve growth factor
- 2015
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Ingår i: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 43, s. 1059-1072
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Tidskriftsartikel (refereegranskat)abstract
- © 2015-IOS Press and the authors. New therapies with disease-modifying effects are urgently needed for treating Alzheimer's disease (AD). Nerve growth factor (NGF) protein has demonstrated regenerative and neuroprotective effects on basal forebrain cholinergic neurons in animal studies. In addition, AD patients treated with NGF have previously shown improved cognition, EEG activity, nicotinic binding, and glucose metabolism. However, no study to date has analyzed brain atrophy in patients treated with NGF producing cells. In this study we present MRI results of the first clinical trial in patients with AD using encapsulated NGF biodelivery to the basal forebrain. Six AD patients received the treatment during twelve months. Patients were grouped as responders and non-responders according to their twelve-months change in MMSE. Normative values were created from 131 AD patients from ADNI, selecting 36 age-and MMSE-matched patients for interpreting the longitudinal changes in MMSE and brain atrophy. Results at baseline indicated that responders showed better clinical status and less pathological levels of cerebrospinal fluid (CSF) Aβ1-42. However, they showed more brain atrophy, and neuronal degeneration as evidenced by higher CSF levels of T-tau and neurofilaments. At follow-up, responders showed less brain shrinkage and better progression in the clinical variables and CSF biomarkers. Noteworthy, two responders showed less brain shrinkage than the normative ADNI group. These results together with previous evidence supports the idea that encapsulated biodelivery of NGF might have the potential to become a new treatment strategy for AD with both symptomatic and disease-modifying effects.
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| 10. |
- Isaksson, Patrik, et al.
(författare)
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The influence of surface roughness on friction in a flexible hybrid bearing
- 2011
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Ingår i: Proceedings of the Institution of mechanical engineers. Part J, journal of engineering tribology. - : SAGE Publications. - 1350-6501 .- 2041-305X. ; 225:J10, s. 975-985
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Tidskriftsartikel (refereegranskat)abstract
- The effect of surface roughness on friction in all lubrication regimes is studied for a flexible hybrid bearing of a radial piston hydraulic motor. The effect is studied by performing experiments in a specially designed test rig and numerical simulations of the real measured surface topographies of the bearings. The simulations are performed with a two-scale model where surface roughness is treated on a local asperity level by homogenized flow factors and a global scale where the bearing structure is included. Three bearings with different surface topographies are included in the study and both experimentally measured and simulated friction are analysed for each of them. Comparison of friction predicted by the model and experimentally measured friction is performed and it reveals that the model is a valuable tool for analysing the effect of surface roughness in this type of bearing
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