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- Ivanova, M.Y, et al.
(författare)
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Testing Syndromes of Psychopathology in Parent and Youth Ratings Across Societies
- 2019
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Ingår i: Journal of clinical child and adolescent psychology. - : Informa UK Limited. - 1537-4416 .- 1537-4424. ; 48:4, s. 596-609
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Tidskriftsartikel (refereegranskat)abstract
- As societies become increasingly diverse, mental health professionals need instruments for assessing emotional, behavioral, and social problems in terms of constructs that are supported within and across societies. Building on decades of research findings, multisample alignment confirmatory factor analyses tested an empirically based 8-syndrome model on parent ratings across 30 societies and youth self-ratings across 19 societies. The Child Behavior Checklist for Ages 6–18 and Youth Self-Report for Ages 11–18 were used to measure syndromes descriptively designated as Anxious/ Depressed, Withdrawn/Depressed, Somatic Complaints, Social Problems, Thought Problems, Attention Problems, Rule-Breaking Behavior, and Aggressive Behavior. For both parent ratings (N = 61,703) and self-ratings (N = 29,486), results supported aggregation of problem items into 8 first-order syndromes for all societies (configural invariance), plus the invariance of item loadings (metric invariance) across the majority of societies. Supported across many societies in both parent and self-ratings, the 8 syndromes offer a parsimonious phenotypic taxonomy with clearly operatio- nalized assessment criteria. Mental health professionals in many societies can use the 8 syndromes to assess children and youths for clinical, training, and scientific purposes.
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| 2. |
- Thompson, PM, et al.
(författare)
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ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
- 2020
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Ingår i: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 10:1, s. 100-
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Tidskriftsartikel (refereegranskat)abstract
- This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of “big data” (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA’s activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors.
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| 4. |
- Bisignano, Paola, et al.
(författare)
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Inhibitor binding mode and allosteric regulation of Na+-glucose symporters.
- 2018
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- Sodium-dependent glucose transporters (SGLTs) exploit sodium gradients to transport sugars across the plasma membrane. Due to their role in renal sugar reabsorption, SGLTs are targets for the treatment of type 2 diabetes. Current therapeutics are phlorizin derivatives that contain a sugar moiety bound to an aromatic aglycon tail. Here, we develop structural models of human SGLT1/2 in complex with inhibitors by combining computational and functional studies. Inhibitors bind with the sugar moiety in the sugar pocket and the aglycon tail in the extracellular vestibule. The binding poses corroborate mutagenesis studies and suggest a partial closure of the outer gate upon binding. The models also reveal a putative Na+ binding site in hSGLT1 whose disruption reduces the transport stoichiometry to the value observed in hSGLT2 and increases inhibition by aglycon tails. Our work demonstrates that subtype selectivity arises from Na+-regulated outer gate closure and a variable region in extracellular loop EL5.
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| 5. |
- Laukka, Petri, et al.
(författare)
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Presenting the VENEC corpus : Development of a cross-cultural corpus of vocal emotion expressions and a novel method of annotating emotion appraisals
- 2010
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Ingår i: Proceedings of the LREC 2010 Workshop on Corpora for Research on Emotion and Affect. - Valetta, Malta : European Language Resources Association. - 2951740867 ; , s. 53-57
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Konferensbidrag (refereegranskat)abstract
- We introduce the Vocal Expressions of Nineteen Emotions across Cultures (VENEC) corpus and present results from initial evaluation efforts using a novel method of annotating emotion appraisals. The VENEC corpus consists of 100 professional actors from 5 English speaking cultures (USA, India, Kenya, Singapore, and Australia) who vocally expressed 19 different affects/emotions (affection, amusement, anger, contempt, disgust, distress, fear, guilt, happiness, interest, lust, negative surprise, neutral, positive surprise, pride, relief, sadness, serenity, and shame), each with 3 levels of emotion intensity, by enacting finding themselves in various emotion-eliciting situations. In all, the corpus contains approximately 6,500 stimuli offering great variety of expressive styles for each emotion category due to speaker, culture, and emotion intensity effects. All stimuli have further been acoustically analyzed regarding pitch, intensity, voice quality, and durational cues. In the appraisal rating study, listeners rated a selection of VENEC-stimuli with regard to the characteristics of the emotion eliciting situation, described in terms of 8 emotion appraisal dimensions (novelty, intrinsic pleasantness, goal conduciveness, urgency, power, self- and other-responsibility, and norm compatibility). First, results showed that the inter-rater reliability was acceptable for all scales except responsibility. Second, the perceived appraisal profiles for the different vocal expressions were generally in accord with predictions based on appraisal theory. Finally, listeners’ appraisal ratings on each scale were significantly correlated with several acoustic characteristics. The results show that listeners can reliably infer several aspects of emotion-eliciting situations from vocal affect expressions, and thus suggest that vocal affect expressions may carry cognitive representational information.
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