| 1. |
- Maragkos, F., et al.
(författare)
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Differential cross-section measurements and R-Matrix calculations for proton elastic scattering on natMg in the energy range Ep,lab=2.70-4.25 MeV, suitable for EBS
- 2023
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Ingår i: Nuclear Instruments and Methods in Physics Research Section B. - : Elsevier. - 0168-583X .- 1872-9584. ; 536, s. 45-54
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Tidskriftsartikel (refereegranskat)abstract
- In the current work the first coherent set of differential cross section values for the natMg(p,p0)natMg elastic scattering covering the Ep,lab = 2700-4250 keV energy range is presented for 6 backscattering detection angles (120 degrees, 130 degrees, 140 degrees, 150 degrees, 160 degrees and 170 degrees). R-Matrix calculations were implemented using the AZURE 2.0 code [1] in an attempt to reproduce the obtained experimental data, whilst taking into account the 24Mg(p,p1)24Mg reaction channel. Both results are suitable for EBS and other IBA applications and, furthermore, they form a basis for a future expansion of the current SigmaCalc [2] evaluation, once more experimental data become available. The measurements were performed in the 5.5 MV TN11 HV Tandem Accelerator and the high precision goniometer of N.C.S.R. 'Demokritos', Athens, Greece. The experimental and data analysis procedures are presented in detail, along with the process behind the implementation of the R-Matrix calculations.
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| 2. |
- Koukoulias, K, et al.
(författare)
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"Cerberus" T Cells: A Glucocorticoid-Resistant, Multi-Pathogen Specific T Cell Product to Fight Infections in Severely Immunocompromised Patients
- 2021
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Ingår i: Frontiers in immunology. - : Frontiers Media SA. - 1664-3224. ; 11, s. 608701-
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Tidskriftsartikel (refereegranskat)abstract
- Adoptive immunotherapy (AI) with pathogen-specific T cells is a promising alternative to pharmacotherapy for the treatment of opportunistic infections after allogeneic hematopoietic cell transplantation or solid organ transplantation. However, clinical implementation of AI is limited to patients not receiving high-dose steroids, a prerequisite for optimal T-cell function, practically excluding the most susceptible to infections patients from the benefits of AI. To address this issue, we here rapidly generated, clinical doses of a steroid-resistant T-cell product, simultaneously targeting four viruses (adenovirus, cytomegalovirus, Epstein Barr virus, and BK virus) and the fungus Aspergillus fumigatus, by genetic disruption of the glucocorticoid receptor (GR) gene using CRISPR/CAS9 ribonucleoprotein delivery. The product, “Cerberus” T cells (Cb-STs), was called after the monstrous three-headed dog of Greek mythology, due to its triple potential; specificity against viruses, specificity against fungi and resistance to glucocorticoids. Following efficient on-target GR disruption and minimal off-target editing, the generated Cb-STs maintained the characteristics of pentavalent-STs, their unedited counterparts, including polyclonality, memory immunophenotype, specificity, and cytotoxicity while they presented functional resistance to dexamethasone. Cb-STs may become a powerful, one-time treatment for severely immunosuppressed patients under glucocorticoids who suffer from multiple, life-threatening infections post-transplant, and for whom therapeutic choices are limited.
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