| 1. |
- Geng, Xin, et al.
(författare)
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Construction of Phenanthridinone Skeletons through Palladium-Catalyzed Annulation
- 2023
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Ingår i: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 88:17, s. 12738-12743
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Tidskriftsartikel (refereegranskat)abstract
- Herein, a straightforward synthetic approach for the construction of phenanthridin-6(5H)-one skeletons is disclosed. The developed protocol relies on palladium catalysis, providing controlled access to a range of functionalized phenanthridin-6(5H)-ones in 59-88% yields. Furthermore, plausible reaction pathways are proposed based on mechanistic experiments.
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| 2. |
- Geng, Xin, et al.
(författare)
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Tandem Palladium/Copper-Catalyzed Decarboxylative Approach to Benzoimidazo- and Imidazophenanthridine Skeletons
- 2022
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Ingår i: Organic Letters. - : American Chemical Society (ACS). - 1523-7060 .- 1523-7052. ; 24:50, s. 9194-9199
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Tidskriftsartikel (refereegranskat)abstract
- A protocol for a tandem Pd/Cu-catalyzed intermolecular cross-coupling cascade between o-bromobenzoic acids and 2-(2-bromoaryl)-1H-benzo[d]imidazoles or the corresponding imidazoles is presented. The protocol provides conceptually novel and controlled access to synthetically useful N-fused (benzo)imidazophenanthridine scaffolds with high efficiency, a broad substrate scope, and excellent functional group compatibility.
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| 3. |
- Shatskiy, Andrey, et al.
(författare)
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Chemodivergent difunctionalization of alkenes through base-controlled radical relay
- 2022
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Ingår i: Chem. - : Elsevier BV. - 2451-9308 .- 2451-9294. ; 8:1, s. 12-14
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Tidskriftsartikel (refereegranskat)abstract
- Establishing chemodivergent synthetic strategies remains a daunting task in the realm of free-radical reaction manifolds. In the December issue of Chem, Glorius and co-workers resolve this challenge for selective difunctionalization of aliphatic alkenes. In the disclosed light-promoted radical relay process, switchable trifluoromethylation/alkylation or trifluoromethylation/sulfonylation of alkenes is achieved.
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| 4. |
- Wang, Y. -C, et al.
(författare)
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Copper-assisted Wittig-type olefination of aldehydes with p-toluenesulfonylmethyl isocyanide
- 2022
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Ingår i: Organic Chemistry Frontiers. - : Royal Society of Chemistry (RSC). - 2052-4110 .- 2052-4129. ; 9:15, s. 4158-4163
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Tidskriftsartikel (refereegranskat)abstract
- The Wittig reaction is a valuable and powerful tool in organic synthesis, providing a convenient route from aldehydes and ketones to alkenes. Herein, a novel copper-assisted Wittig-type olefination of aldehydes with p-toluenesulfonylmethyl isocyanide (TosMIC) is disclosed, providing a direct and operationally simple approach to (E)-vinyl sulfones under mild conditions, compatible with a multitude of common functional groups. Experimental and computational investigations imply that the reaction proceeds through an intriguing electronically-controlled (3 + 2)/retro-(3 + 2) cycloaddition pathway.
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| 5. |
- Xu, L., et al.
(författare)
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Silver-Catalyzed Controlled Intermolecular Cross-Coupling of Silyl Enol Ethers : Scalable Access to 1,4-Diketones
- 2022
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Ingår i: Organic Letters. - : American Chemical Society (ACS). - 1523-7060 .- 1523-7052. ; 24:25, s. 4513-4518
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Tidskriftsartikel (refereegranskat)abstract
- A protocol for silver-catalyzed controlled intermolecular cross-coupling of silyl enolates is disclosed. The protocol displays good functional group tolerance and allows efficient preparation of a series of synthetically useful 1,4-diketones. Preliminary mechanistic investigations suggest that the reaction proceeds through a one-electron process involving free radical species in which PhBr acts as the oxidant.
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