SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Amer M) "

Sökning: WFRF:(Amer M)

  • Resultat 1-10 av 109
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • 2021
  • swepub:Mat__t
  •  
2.
  • Thomas, HS, et al. (författare)
  • 2019
  • swepub:Mat__t
  •  
3.
  •  
4.
  •  
5.
  • de Rojas, I., et al. (författare)
  • Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
  • 2021
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease. © 2021, The Author(s).
  •  
6.
  •  
7.
  •  
8.
  • 2019
  • Tidskriftsartikel (refereegranskat)
  •  
9.
  • James, SL, et al. (författare)
  • Global injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017
  • 2020
  • Ingår i: Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention. - : BMJ. - 1475-5785. ; 26:SUPP_1Supp 1, s. 96-114
  • Tidskriftsartikel (refereegranskat)abstract
    • Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries.MethodsWe reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs).FindingsIn 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505).InterpretationInjuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 109
Typ av publikation
tidskriftsartikel (95)
konferensbidrag (7)
rapport (3)
forskningsöversikt (2)
Typ av innehåll
refereegranskat (98)
övrigt vetenskapligt/konstnärligt (9)
Författare/redaktör
Savani, Bipin N (25)
Olsson, Richard (23)
Seo, Sachiko (23)
Nishihori, Taiga (22)
Lazarus, Hillard M (21)
Beitinjaneh, Amer (21)
visa fler...
Ganguly, Siddhartha (20)
Yared, Jean A. (20)
Aljurf, Mahmoud (19)
Gale, Robert Peter (18)
Saber, Wael (17)
Chhabra, Saurabh (16)
Hildebrandt, Gerhard ... (15)
DeFilipp, Zachariah (15)
Cerny, Jan (14)
Kamble, Rammurti T. (14)
Wirk, Baldeep (14)
Solh, Melhem (14)
Inamoto, Yoshihiro (13)
Gergis, Usama (13)
Kharfan-Dabaja, Moha ... (12)
Abdel-Azim, Hisham (12)
Hashmi, Shahrukh (12)
Marks, David I. (12)
Bacher, Ulrike (12)
Hematti, Peiman (11)
Cahn, Jean-Yves (11)
Murthy, Hemant S (11)
Farhadfar, Nosha (11)
Nathan, Sunita (10)
Daly, Andrew (10)
Verdonck, Leo F (10)
Olsson, Richard F (10)
Byrne, Michael (10)
Grunwald, Michael R. (10)
Rizzieri, David (9)
Copelan, Edward (9)
Litzow, Mark (9)
Weisdorf, Daniel (9)
Buchbinder, David (9)
Popat, Uday (9)
Majhail, Navneet S. (8)
Diaz, Miguel Angel (8)
Freytes, Cesar O. (8)
Saad, Ayman (8)
Ustun, Celalettin (8)
Agrawal, Vaibhav (8)
Gadalla, Shahinaz M (8)
Hu, Zhen-Huan (8)
Kindwall-Keller, Tam ... (8)
visa färre...
Lärosäte
Karolinska Institutet (73)
Uppsala universitet (44)
Lunds universitet (17)
Göteborgs universitet (12)
Umeå universitet (8)
Stockholms universitet (7)
visa fler...
Chalmers tekniska högskola (6)
Linköpings universitet (5)
Örebro universitet (4)
Kungliga Tekniska Högskolan (3)
Sveriges Lantbruksuniversitet (3)
Luleå tekniska universitet (2)
Högskolan i Borås (2)
Sophiahemmet Högskola (2)
Högskolan i Halmstad (1)
Jönköping University (1)
visa färre...
Språk
Engelska (108)
Svenska (1)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (74)
Naturvetenskap (18)
Teknik (8)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy