| 1. |
- Zouganelis, I., et al.
(författare)
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The Solar Orbiter Science Activity Plan : Translating solar and heliospheric physics questions into action
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP SCIENCES S A. - 0004-6361 .- 1432-0746. ; 642
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Tidskriftsartikel (refereegranskat)abstract
- Solar Orbiter is the first space mission observing the solar plasma both in situ and remotely, from a close distance, in and out of the ecliptic. The ultimate goal is to understand how the Sun produces and controls the heliosphere, filling the Solar System and driving the planetary environments. With six remote-sensing and four in-situ instrument suites, the coordination and planning of the operations are essential to address the following four top-level science questions: (1) What drives the solar wind and where does the coronal magnetic field originate?; (2) How do solar transients drive heliospheric variability?; (3) How do solar eruptions produce energetic particle radiation that fills the heliosphere?; (4) How does the solar dynamo work and drive connections between the Sun and the heliosphere? Maximising the mission's science return requires considering the characteristics of each orbit, including the relative position of the spacecraft to Earth (affecting downlink rates), trajectory events (such as gravitational assist manoeuvres), and the phase of the solar activity cycle. Furthermore, since each orbit's science telemetry will be downloaded over the course of the following orbit, science operations must be planned at mission level, rather than at the level of individual orbits. It is important to explore the way in which those science questions are translated into an actual plan of observations that fits into the mission, thus ensuring that no opportunities are missed. First, the overarching goals are broken down into specific, answerable questions along with the required observations and the so-called Science Activity Plan (SAP) is developed to achieve this. The SAP groups objectives that require similar observations into Solar Orbiter Observing Plans, resulting in a strategic, top-level view of the optimal opportunities for science observations during the mission lifetime. This allows for all four mission goals to be addressed. In this paper, we introduce Solar Orbiter's SAP through a series of examples and the strategy being followed.
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| 2. |
- Berthomier, M., et al.
(författare)
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Alfven : magnetosphere-ionosphere connection explorers
- 2012
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Ingår i: Experimental astronomy. - Dordrecht : Springer. - 0922-6435 .- 1572-9508. ; 33:2-3, s. 445-489
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Tidskriftsartikel (refereegranskat)abstract
- The aurorae are dynamic, luminous displays that grace the night skies of Earth's high latitude regions. The solar wind emanating from the Sun is their ultimate energy source, but the chain of plasma physical processes leading to auroral displays is complex. The special conditions at the interface between the solar wind-driven magnetosphere and the ionospheric environment at the top of Earth's atmosphere play a central role. In this Auroral Acceleration Region (AAR) persistent electric fields directed along the magnetic field accelerate magnetospheric electrons to the high energies needed to excite luminosity when they hit the atmosphere. The "ideal magnetohydrodynamics" description of space plasmas which is useful in much of the magnetosphere cannot be used to understand the AAR. The AAR has been studied by a small number of single spacecraft missions which revealed an environment rich in wave-particle interactions, plasma turbulence, and nonlinear acceleration processes, acting on a variety of spatio-temporal scales. The pioneering 4-spacecraft Cluster magnetospheric research mission is now fortuitously visiting the AAR, but its particle instruments are too slow to allow resolve many of the key plasma physics phenomena. The Alfv,n concept is designed specifically to take the next step in studying the aurora, by making the crucial high-time resolution, multi-scale measurements in the AAR, needed to address the key science questions of auroral plasma physics. The new knowledge that the mission will produce will find application in studies of the Sun, the processes that accelerate the solar wind and that produce aurora on other planets.
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| 3. |
- Georgali, E., et al.
(författare)
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Experimental study of the 165Ho(n, 2n) reaction : Cross section measurements for the population of the 164Ho ground state and isomeric state from the threshold up to 20 MeV
- 2020
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 102:3
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Tidskriftsartikel (refereegranskat)abstract
- In the present work the 165Ho(n,2n) reaction was studied experimentally and theoretically for the population of the ground state (Jπ=1+) of the 164Ho product nucleus, as well as for the population of its isomeric state (Eex=139.8 keV, Jπ=6−). The cross sections of both the ground and isomeric state channels were measured at energies near the reaction threshold (Eth=8.04 MeV), at 10.1, 10.4, and 10.7 MeV, as well as at energies higher than 17 MeV, at 17.1, 18.1, 19.0, and 19.6 MeV. The adopted method was the activation technique relative to the 197Au(n,2n) 196Au and 27Al(n,α)24Na reference reactions. The quasi-monoenergetic neutron beams for the near threshold energies were produced via the 2H(d,n)3He reaction, while for the neutron beams above 17 MeV the 3H(d,n)4He reaction was utilized. In both cases the deuteron beams were delivered by the 5.5 MV Tandem Van de Graaff accelerator of the Institute of Nuclear and Particle Physics at N.C.S.R. “Demokritos”. Additional to the experimental study, calculations were performed using the talys code (v. 1.9). The experimental data of the present work along with the previous measurements were compared with the talys results so as to investigate the reproduction of the experimental data for the different level density models of the code.
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| 4. |
- Georgali, E., et al.
(författare)
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Cross-section measurements of the Dy-156(n, 2n)Dy-155 reaction at neutron energies higher than 17 MeV
- 2021
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Ingår i: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 104:6
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Tidskriftsartikel (refereegranskat)abstract
- In the present work the cross section of the 156Dy (n, 2n) 155Dy reaction (Eth = 9.51 MeV) was measured at neutron beam energies above 17 MeV: 17.1, 18.1, and 19.0 MeV. The irradiations were performed at the 5.5-MV tandem accelerator of the Institute of Nuclear and Particle Physics at N.C.S.R. "Demokritos", where quasimonoenergetic neutron beams were produced via the 3H (d, n) 4He reaction. The cross-section measurements were performed by means of the activation technique relative to the 27Al (n, alpha) 24Na reference reaction. Within the present work the experimental study is framed by theoretical calculations performed via the TALYS code (version 1.95).
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| 5. |
- Gerousi, M, et al.
(författare)
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The Calcitriol/Vitamin D Receptor System Regulates Key Immune Signaling Pathways in Chronic Lymphocytic Leukemia
- 2021
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 13:2
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Tidskriftsartikel (refereegranskat)abstract
- It has been proposed that vitamin D may play a role in prevention and treatment of cancer while epidemiological studies have linked vitamin D insufficiency to adverse disease outcomes in various B cell malignancies, including chronic lymphocytic leukemia (CLL). In this study, we sought to obtain deeper biological insight into the role of vitamin D and its receptor (VDR) in the pathophysiology of CLL. To this end, we performed expression analysis of the vitamin D pathway molecules; complemented by RNA-Sequencing analysis in primary CLL cells that were treated in vitro with calcitriol, the biologically active form of vitamin D. In addition, we examined calcitriol effects ex vivo in CLL cells cultured in the presence of microenvironmental signals, namely anti-IgM/CD40L, or co-cultured with the supportive HS-5 cells; and, CLL cells from patients under ibrutinib treatment. Our study reports that the calcitriol/VDR system is functional in CLL regulating signaling pathways critical for cell survival and proliferation, including the TLR and PI3K/AKT pathways. Moreover, calcitriol action is likely independent of the microenvironmental signals in CLL, since it was not significantly affected when combined with anti-IgM/CD40L or in the context of the co-culture system. This finding was also supported by our finding of preserved calcitriol signaling capacity in CLL patients under ibrutinib treatment. Overall, our results indicate a relevant biological role for vitamin D in CLL pathophysiology and allude to the potential clinical utility of vitamin D supplementation in patients with CLL.
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| 6. |
- Aminalragia-Giamini, Sigiava, et al.
(författare)
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Solar Energetic Particle Event occurrence prediction using Solar Flare Soft X-ray measurements and Machine Learning
- 2021
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Ingår i: Journal of Space Weather and Space Climate. - : EDP Sciences. - 2115-7251. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- The prediction of the occurrence of Solar Energetic Particle (SEP) events has been investigated over many years, and multiple works have presented significant advances in this problem. The accurate and timely prediction of SEPs is of interest to the scientific community as well as mission designers, operators, and industrial partners due to the threat SEPs pose to satellites, spacecrafts, and crewed missions. In this work, we present a methodology for the prediction of SEPs from the soft X-rays of solar flares associated with SEPs that were measured in 1 AU. We use an expansive dataset covering 25 years of solar activity, 1988-2013, which includes thousands of flares and more than two hundred identified and catalogued SEPs. Neural networks are employed as the predictors in the model, providing probabilities for the occurrence or not of a SEP, which are converted to yes/no predictions. The neural networks are designed using current and state-of-the-art tools integrating recent advances in the machine learning field. The results of the methodology are extensively evaluated and validated using all the available data, and it is shown that we achieve very good levels of accuracy with correct SEP occurrence prediction higher than 85% and correct no-SEP predictions higher than 92%. Finally, we discuss further work towards potential improvements and the applicability of our model in real-life conditions.
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| 7. |
- Cuerda, C., et al.
(författare)
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Original article Nutrition education in medical schools (NEMS) project: Joining ESPEN and university point of view
- 2021
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Ingår i: Clinical Nutrition. - : Elsevier BV. - 0261-5614. ; 40:5, s. 2754-2761
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Tidskriftsartikel (refereegranskat)abstract
- Background & aims: Nutrition education is not well represented in the medical curriculum. The aim of this original paper was to describe the Nutrition Education in Medical Schools (NEMS) Project of the European Society for Clinical Nutrition and Metabolism (ESPEN). Methods: On 19 January 2020, a meeting was held on this topic that was attended by 51 delegates (27 council members) from 34 countries, and 13 European University representatives. Results: This article includes the contents of the meeting that concluded with the signing of the Manifesto for the Implementation of Nutrition Education in the Undergraduate Medical Curriculum. Conclusion: The meeting represented a significant step forward, moved towards implementation of nutrition education in medical education in general and in clinical practice in particular, in compliance with the aims of the ESPEN Nutrition Education Study Group (NESG). 0 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
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| 8. |
- Georgali, E., et al.
(författare)
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Using GEANT4 Monte Carlo simulations to resolve low energy γ-ray spectra : The study of 164Hog+m decay using a broad energy HPGe detector
- 2021
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier. - 0168-9002 .- 1872-9576. ; 985
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Tidskriftsartikel (refereegranskat)abstract
- Within the present work a peak analysis and unfolding method for low energy γ-ray spectroscopy is presented. This method can be used to facilitate the determination of the peak integral of a photopeak, when Ge X-ray escape peaks contaminate the latter and in parallel the source activity and the emission rate of the recorded photons which produce the escape peaks are unknown. It is based on extensive Monte Carlo simulations of the spectra by taking the full advantage of power and accuracy provided by the GEANT4 simulation toolkit.
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