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- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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- Andersson, Ann-Catrin, et al.
(författare)
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Analysis of protein expression in cell microarrays : A tool for antibody-based proteomics
- 2006
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Ingår i: Journal of Histochemistry and Cytochemistry. - 0022-1554 .- 1551-5044. ; 54:12, s. 1413-1423
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Tidskriftsartikel (refereegranskat)abstract
- Tissue microarray (TMA) technology provides a possibility to explore protein expression patterns in a multitude of normal and disease tissues in a high-throughput setting. Although TMAs have been used for analysis of tissue samples, robust methods for studying in vitro cultured cell lines and cell aspirates in a TMA format have been lacking. We have adopted a technique to homogeneously distribute cells in an agarose gel matrix, creating an artificial tissue. This enables simultaneous profiling of protein expression in suspension- and adherent-grown cell samples assembled in a microarray. In addition, the present study provides an optimized strategy for the basic laboratory steps to efficiently produce TMAs. Presented modifications resulted in an improved quality of specimens and a higher section yield compared with standard TMA production protocols. Sections from the generated cell TMAs were tested for immunohistochemical staining properties using 20 well-characterized antibodies. Comparison of immunoreactivity in cultured dispersed cells and corresponding cells in tissue samples showed congruent results for all tested antibodies. We conclude that a modified TIVIA technique, including cell samples, provides a valuable tool for high-throughput analysis of protein expression, and that this technique can be used for global approaches to explore the human proteome.
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- Andersson, Ann-Catrin, et al.
(författare)
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Elevated levels of the human endogenous retrovirus ERV3 in human sebaceous glands
- 1996
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Ingår i: Journal of Investigative Dermatology. - : Elsevier BV. - 0022-202X .- 1523-1747. ; 106:1, s. 125-128
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Tidskriftsartikel (refereegranskat)abstract
- ERV3 (HERV-R) is a complete human endogenous retrovirus located on the long arm of chromosome 7. Long terminal repeat-envelope (env) gene spliced mRNAs of 9 and 3.5 kb are widely expressed in human tissues and cells, but gag-pol mRNAs have not been found. Furthermore, the env gp70 gene contains an open reading frame throughout its length. The highest expression of ERV3 mRNA detected so far is in placenta and the lowest in choriocarcinoma cell lines. We have previously shown that the human monoblastic cell line U-937 and some normal and neoplastic tissues also express high levels of ERV3 env message by Northern blot analysis; however, this method does not distinguish between mRNA expression in different cell types in tissues. In this report, we have studied the ERV3 mRNA expression in specific cell types of human skin by in situ hybridization. We found high levels expression of ERV3 env mRNA in human sebaceous glands in normal skin and dermoid cysts of the ovary. In all glands, the expression is maximal in the periphery of the lobule and ceases towards the center in the region of characteristic holocrine secretion. Since it is known that the regulation of sebaceous glands is primarily via steroid hormones, particularly androgens, it is possible that expression of ERV3 is hormone dependent.
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- Andersson, Ann-Catrin, 1973-
(författare)
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Geopolitical importance of cities
- 2008
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- One way to analyze globalization is to highlight a reordering of spatial scales. Traditional territorial units such as nation-states are not necessarily replaced but rather complemented by other kinds of units. One such unit that has attracted the attention of researchers in the field of geopolitics is the urban area and the city. The urban space can be both a geopolitically important arena where for instance war takes place, but urban space can also be constructed for various purposes and sometimes has great symbolic value on its own. The purpose of the paper is to explore the geopolitical importance of cities, compared to other territorial entities and to build a bridge between traditional geopolitics and urban studies. The paper explores images of the city as a geopolitical arena and the city as a space for everyday life. The paper furthermore scrutinizes the link between urban politics and identity, drawing from discussions on the city as; 1. a symbolic space, 2. a contested space and, 3. a space for identity politics. Empirical illustrations will be taken from earlier studies within this field but also from a field study performed in Jerusalem 2007. This paper contributes to an ongoing discussion on the gap between more ”traditional” geopolitical analyses and critical-constructivist approaches.
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| 10. |
- Andersson, Ann-Catrin
(författare)
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Good governance utan stat - fallet Palestina
- 2009. - 1
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Ingår i: Governance på svenska. - Stockholm : Santérus Academic Press Sweden. - 9789173350211 ; , s. 57-82
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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