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- Abdurahman, Samir, 1965-, et al.
(författare)
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Activity of the small modified amino acid alpha-hydroxy glycineamide on in vitro and in vivo human immunodeficiency virus type 1 capsid assembly and infectivity
- 2008
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Ingår i: Antimicrobial Agents and Chemotherapy. - 0066-4804 .- 1098-6596. ; 52:10, s. 3737-3744
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Tidskriftsartikel (refereegranskat)abstract
- Upon maturation of the human immunodeficiency virus type 1 (HIV-1) virion, proteolytic cleavage of the Gag precursor protein by the viral protease is followed by morphological changes of the capsid protein p24, which will ultimately transform the virus core from an immature spherical to a mature conical structure. Virion infectivity is critically dependent on the optimal semistability of the capsid cone structure. We have reported earlier that glycineamide (G-NH(2)), when added to the culture medium of infected cells, inhibits HIV-1 replication and that HIV-1 particles with aberrant core structures were formed. Here we show that it is not G-NH(2) itself but a metabolite thereof, alpha-hydroxy-glycineamide (alpha-HGA), that is responsible for the antiviral activity. We show that alpha-HGA inhibits the replication of clinical HIV-1 isolates with acquired resistance to reverse transcriptase and protease inhibitors but has no effect on the replication of any of 10 different RNA and DNA viruses. alpha-HGA affected the ability of the HIV-1 capsid protein to assemble into tubular or core structures in vitro and in vivo, probably by binding to the hinge region between the N- and C-terminal domains of the HIV-1 capsid protein as indicated by matrix-assisted laser desorption ionization-mass spectrometry results. As an antiviral compound, alpha-HGA has an unusually simple structure, a pronounced antiviral specificity, and a novel mechanism of antiviral action. As such, it might prove to be a lead compound for a new class of anti-HIV substances.
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- Andersson, Bo, Docent, 1965-, et al.
(författare)
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Developing M-Services : Lessons Learned From the Developers Perspective.
- 2007
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Ingår i: Communications of the Association for Information Systems. - : Association for Information Systems. - 1529-3181. ; 20:38, s. 605-620
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Tidskriftsartikel (refereegranskat)abstract
- In recent years the Swedish Police Force (SPF) have encountered greater demands on availability and 24/7 services when dealing with errands that are regarded as low priority compared to regular police work, e.g. collecting tips from the public. One attempt to meet these increasing demands was the development of a mobile communications platform that allowed the public to communicate easily with the SPF using their own mobile phones by sending SMS and MMS. The focus of this paper is on the early phases of development of this m-service, in particular, on the specific technical issues such as interoperability and standards used by the actors on the scene affecting the development of mobile information systems. The learning experiences are as follows: First, mobile communication platforms have a large potential for contributing to the field of emergency management information systems since they can be based on open and nationally accepted standards. Second, global and national standards for sending multimedia messages are not always truly standardized. Operators and mobile phone manufacturers make minor alterations and interpretations of the standard and thereby some of the benefits found in standards disappear. Third, when developing mobile information systems we suggest and recommend that the analysis phase should be enhanced compared to traditional system development, and it should address the interoperability between mobile phones on one hand and operators on the other hand.
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- Andersson, Bo, 1965-, et al.
(författare)
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Developing Mobile Information Systems : Managing Additional Aspects
- 2010
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Ingår i: 18th European Conference on Information Systems, ECIS 2010. - 9780620471725
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Konferensbidrag (refereegranskat)abstract
- Despite the numerous stories in academic journals and the business press of systems that fail to deliver anticipated benefits, mobile information systems (IS) are still gaining ground. The nature of mobile IS introduces additional aspects that require attention during the development process, compared to more traditional information systems built for stationary computers. The underlying assumption in this paper is that successful management of these aspects is crucial in order to harness the possibilities of mobility. This paper presents the AUDE- (Application, User, Device, Environment) framework; an analytical framework that addresses the additional aspect of mobile IS. The framework integrates previous research on mobile IS and is tested retrospectively on a case with mobile service technicians. Of the 19 attributes covered by the AUDE framework 2 attributes were not applicable in the investigated case. Of the remaining 17 attributes only 6 were actively handled (3 of them only partly), 8 were not taken into account, and for 3 we were not able to retrieve data. With the ignorance of specific attributes for mobile IS development it was possible to explain why the developed IS did not meet expectations and was considered a failure by its users.
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- Andersson, Bo, Docent, 1965-, et al.
(författare)
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Enhancing Information Quality as Part of the Disease Surveillance System in Malawi, Africa : Reflections on a mHealth Intervention
- 2017
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Ingår i: Information Systems Development: Advances in Methods, Tools and Management. - Larnaca : Association for Information Systems. - 9789963228836
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Konferensbidrag (refereegranskat)abstract
- Public health surveillance and response to disease outbreaks is still a hurdle in many developing countries across sub-Saharan Africa. Pivotal in disease surveillance and response is the reliance on valid information, hence, the need for information which has high Information Quality (IQ) characteristics. A key issue with disease surveillance systems, stem from the diverse range of data sources with various levels of information quality that may affect the trustworthiness of the information. However, with the increasing diffusion of mobile phone technologies, there are opportunities to improve IQ. The aim of this study was to assess the information quality in data collected through a smartphone application. Based on qualitative data from interviews, workshop and system specifications, it was found that information quality improves with the use of smartphone applications but aspects such as user competence and trustworthiness, must be addressed to maximize the benefits of using mobile technologies for disease surveillance.
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- Andersson, Bo, Docent, 1965-, et al.
(författare)
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File-Sharing : A Threat to Intellectual Property Rights, or is the Music Industry Just Taking Us for a Spin?
- 2009
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Ingår i: In proceedings of the 17th European Conference on Information Systems (ECIS). - : Association for Information Systems.
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Konferensbidrag (refereegranskat)abstract
- File-sharing has become synonym with the “digital economy” where large music conglomerates as well as certain artist voice strong concern over the impact on their bottom line. This research analyzes the music industry, which has been heavily impacted by a major technological shift i.e. the invention, and rollout, of the Internet. We look to the technological shift that has enabled the downloading phenomenon, as well as analyze the uniqueness of the music industries situation. By comparing the book publishing industry as well as the software industry, which are arguably also influenced by intellectual property rights and plagiarism, we try to find similarities as well as dissimilarities with the music industry. We find that the music industry has used alliances as well as Mergers and Acquisitions in order to consolidate their positions in an attempt to slow down change. There is no consensus on the exact extent of ill effects of file sharing. We point to an unwillingness to achieve convergence of purpose between the IT-community and the much of the music industry. Finally we point to the historical fact that consumers always get what they want in the end, which should indicate a need to find a viable e-commerce solution.
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- Andersson, Bo, Docent, 1965-
(författare)
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Handheld Computing from a Designer's Perspective : A 10-Year Review 2001-2010
- 2012
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Ingår i: In proceedings of the 45th Hawaii International Conference on System Sciences (HICSS), 4-7 January, 2012, Hawaii. - Maui, HA : IEEE. - 9781457719257 - 9780769545257
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Konferensbidrag (refereegranskat)abstract
- This review has examined research on handheld computing from a design science perspective. The review was underpinned by the assumption that handheld computing has specific features compared to stationary computing that ought to be managed in order to harness the possibilities of handheld computing. The purpose of this study was to identify areas of investigation in handheld computing from a design-orientated perspective. Publications were analysed by four dimensions: handheld computing, design oriented approach, accentuated factors of handheld computing and organisational settings -- whether or not the users were a member of the mobile workforce. The findings revealed that research on handheld computing is unevenly distributed and that research on the mobile workforce is under-represented. A reflection made is that more research on factors such as field use conditions, support issues, supporting technologies and time critical is needed in order to harness the possibilities of handheld computing.
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