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- Andersson, Anne, 1966-
(författare)
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Long-term side effects after treatment of Hodgkin's lymphoma
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background Long-term side effects associated with the treatment of Hodgkin’s lymphoma (HL) have frequently been reported during the last decades. Studies have shown increased mortality in HL survivors. Following Hodgkin’s lymphoma, second malignancies (SM) and cardiovascular disease (CVD) are the most common causes of death in individuals treated for HL. This study investigates the incidence of side effects such as SM, CVD and infections in a cohort diagnosed with HL in Sweden between 1965 and 1995. In addition, this study identifies covariate risk factors for late side effects in order to develop strategies that prevent morbidity and mortality in HL survivors. Methods Using the Swedish Cancer Registry (SCR) at the National Board of Health and Welfare and the Multi-Generation Registry at Statistics (MGR) Sweden, we identified 6946 individuals diagnosed with HL between the years 1965 and 1995, and their first degree relatives (FDR) (n=17 858). In addition we identified the malignancies and inpatient care for CVD and infections for the HL cohort and their FDR. The standard incidence ratio (SIR) was calculated for the risk of SM, CVD and infections. For SM and CVD the risk also was stratified and calculated for family history of disease. The Swedish Hodgkin Intervention and Prevention study (SHIP), a prospective study, invited 702 individuals treated for HL at the age of 45 years or younger and who were treated in the region of Skåne, Uppsala or Umeå. The participants completed a questionnaire and were invited to an out-patient visit to an oncologist with clinical examination and blood tests. Any pathological findings were referred for further investigation. Results An increased risk for SM in HL long-term survivors was observed and seems to increase with the number of FDRs with cancer. There was also an increased risk for inpatient care due to congestive heart failure (CHF) and coronary artery disease (CAD). A family history of CHF and CAD further increased the risk for these diseases. The risk for inpatient care due to infections was increased and remained increased after 20 years or longer. The risk for infections was associated with splenectomy and hypothyroidism. Radiotherapy was an independent risk factor for cardiovascular disease in the cohort of the prospective study. ConclusionLong-term survivors from HL have an increased risk for developing late side effects such as SM, CVD and infections. Since many HL patients are young and the cure rate from the disease is high, it is of great importance to offer focused surveillance programs to selected individuals who are at high risk, e.g. individuals who received radiotherapy as part of their treatment and who have other known risk factors for cardiovascular disease such as hypertension, hypercholesterolemia, family history and smoking.
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- Andersson, Gunnar, et al.
(författare)
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The demographics of same-sex marriages in Norway and Sweden
- 2006
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Ingår i: Demography. ; 43:1, s. 79-98
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Tidskriftsartikel (refereegranskat)abstract
- The present study provides an investigation into the demographics of same-sex marriages, that is registered partnerships, in Norway and Sweden. We give an overview of the demographic characteristics of the spouses of these partnerships, and study patterns in divorce risks. A comparison with similar dynamics of heterosexual marriages is provided. Our study is based on longitudinal information from the population registers of the two countries, covering all persons in partnerships. Our demographic analyses involve information on the characteristics such as age, sex, geographical background, experience of previous opposite-sex marriage, parenthood, and educational attainment of the partners involved. We find that in many respects the distributions of married populations as to these characteristics differ by the sex composition of couples. Patterns in divorce risks are rather similar in same-sex and opposite-sex marriages, but divorce-risk levels are considerably higher in same-sex partnerships. The divorce risk for female partnerships is practically double that of the risk for male partnerships.
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- Andersson, Harald, 1987-, et al.
(författare)
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A numerical and experimental investigation of a confluent jets ventilation supply device in a conference room
- 2022
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Ingår i: Energies. - : MDPI. - 1996-1073. ; 15:5
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Tidskriftsartikel (refereegranskat)abstract
- In this study, confluent jets ventilation (CJV) supply devices with three different nozzle arrays (1 × 19, 2 × 19, 3 × 19) were investigated both numerically and experimentally at two different airflow and supply air temperature set-ups. The performance of the CJV supply devices was investigated concerning thermal comfort, indoor air quality (IAQ), and heat removal effectiveness in a conference room environment. A comparison between the experimental and numerical results showed that the v2−f model had the best agreement out of the investigated turbulence models. The numerical results showed that the size of the array had a great impact both on near-field development and on the conditions in the occupied zone. A larger array with multiple rows and a lower momentum conserved the inlet temperature and the mean age of the air better than a single-row array with a higher momentum. A larger array with multiple rows had a higher IAQ and a greater heat removal effectiveness in the occupied zone because the larger array conserved the mean age of air better and the buoyancy driven flow was slightly better at removing the heat. Because of the lower inlet velocities, they also had lower velocities at ankle level, which decreased the risk of draft and thermal discomfort.
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- Andersson, Harald, 1987-, et al.
(författare)
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An Investigation Concerning Optimal Design of Confluent Jets Ventilation with Variable Air Volume
- 2023
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Ingår i: The International Journal of Ventilation. - : Taylor & Francis. - 1473-3315 .- 2044-4044.
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Tidskriftsartikel (refereegranskat)abstract
- This parametric study aims to predict the performance of confluent jets ventilation (CJV) with variable air volume (VAV) from four CJV design parameters. A combination of computational fluid dynamics (CFD), and response surface method (RSM) has been used to predict the energy efficiency, thermal comfort and IAQ for the four expected vital design variables, i.e., heat load (XH), number of nozzles (XN), airflow rate (XQ) and supply temperature (XTS). The RSM was used to generate a quad-ratic equation for the response variables exhaust temperature (TE), sup-ply temperature (TP), PMV, DR, eT and ACE. The RSM shows that the TE, TP and PMV were independent of the number of nozzles. The proposed equations were used to generate setpoints optimized for thermal com-fort (PMV) for summer, spring and winter cases with different CLO fac-tors and different TS under a scenario where the heat load varied between 10-30W/m2. TE was used as setpoint to regulate the airflow rate to keep the PMV values close to zero. The results show that by adapting the TS to the CLO factor both thermal comfort and the energy efficiency can be improved. Further energy reduction can be gained by downregulating the airflow rate to keep the TP at a fixed setpoint when the heat load is decreased. This means that a CJV can effectively be combined with VAV to improve environmental performance with good thermal comfort (-0.5
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- Andersson, Harald, et al.
(författare)
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Energy-Saving Measures in a Classroom Using Low Pressure Drop Ceiling Supply Device : A Field Study
- 2016
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Ingår i: 2016 ASHRAE Winter Conference Papers. - : ASHRAE. - 9781939200136
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Konferensbidrag (refereegranskat)abstract
- Between 1990 and 2006 the energy use by ventilation systems in Swedish schools doubled. This is explained by high airflows in schools because of the high occupant density. Studies show that 87% of Swedish schools use constant air volume (CAV), and it is estimated that a change to variable air volume (VAV) could save 0.12-0.33 TWh (4.1*10(12) - 1.1*10(13) Btu) per year. Therefore the aim of this study is to investigate whether it is possible to replace displacement ventilation (DV) with mixing ventilation (MV) to create a comfortable indoor climate in a typical classroom and at the same time decrease the energy use by using VAV and Low Pressure Drop Ceiling Supply Device (LPDCSD). The study used two LPDCSDs which consist of circular channels with 190/228 round jets placed in an interlocking pattern, with a horizontal one/two-way-direction. The field study was carried out in a school which is intended to be extensively renovated. The school currently has DV and CAV. The study was carried out by installing MV with LPDCSD in one of the typical classrooms. Several different air-flow rates were investigated using tracer-gas technology to measure the local mean age of the air in the occupied zone. Simultaneously, thermal comfort and vertical temperature gradients were measured in the room. The results show nearly uniform distribution of the local mean age of air in the occupied zone, even in the cases of relatively low air-flow rates. Since the mixing of air is more or less the same in the entire occupied zone VAV can be used to reduce air-flow rate based on the desired CO2-level. Because of the number of students in each classroom and the fact that changes in air-flow rates have no significant effect on the degree of mixing, it is possible to reduce the air-flow rates for extended periods of time. Finally, since the LPDCSD has a lower pressure-drop than the currently used supply devices and it is possible to use VAV to lower the airflows in cases with reduced heat loads, it is possible to significantly reduce the energy usage in the school while maintaining the IAQ, increasing the thermal comfort and the available floor area of the occupied zone.
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- Andersson, Harald, et al.
(författare)
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Experimental and numerical investigations of a new ventilation supply device based on confluent jets
- 2018
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Ingår i: Building and Environment. - : Elsevier BV. - 0360-1323 .- 1873-684X. ; 137, s. 18-33
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Tidskriftsartikel (refereegranskat)abstract
- In developed countries, heating, ventilation, air conditioning (HVAC) systems account for more than 10% of national energy use. The primary function of a HVAC system is to create proper indoor environment. A number of ventilation strategies have been developed to minimize HVAC systems’ energy use whilst still maintaining a good indoor environment. Among these strategies are confluent jet ventilation and variable air volume. In this study, an air supply device with a novel nozzle design that uses both of the above-mentioned strategies was investigated both experimentally and numerically at three different airflow rates. The results from the numerical investigation using the SST k - ω turbulence model regarding velocities and flow patterns are validated by experimental data carried out by Laser Doppler Anemometry. The results from both studies show that the flow pattern and velocity in each nozzle is directly dependent on the total airflow rate. However, the flow pattern does not vary between the three different airflow rates. The numerical investigation shows that velocity profiles for each nozzle have the same pattern regardless of the airflow rate, but the magnitude of the velocity profile increases as the airflow increases. Thus, a supply device of this kind could be used for variable air volume and produce confluent jets for the airflow rates investigated.
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