| 1. |
- Andersson Trojer, Markus, 1981, et al.
(författare)
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Charged microcapsules for controlled release of hydrophobic actives. Part III: The effect of polyelectrolyte brush- and multilayers on sustained release
- 2013
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Ingår i: Physical Chemistry Chemical Physics. - : Royal Society of Chemistry (RSC). - 1463-9084 .- 1463-9076. ; 15:17, s. 6153-6165
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Tidskriftsartikel (refereegranskat)abstract
- Poly(methyl methacrylate) microspheres have been prepared by the internal phase separation method using either of the three conventional dispersants poly(vinyl alcohol) (PVA), poly(methacrylic acid) (PMAA), or the amphiphilic block copolymer poly(methyl methacrylate)-block-poly(sodium methacrylate). The block copolymer based microsphere, which has a polyelectrolyte brush on the surface, was surface modified with up to two poly(diallyldimethylammonium chloride)-poly(sodium methacrylate) bilayers. The microspheres were loaded with the hydrophobic dye 2-(4-(2-chloro-4-nitrophenylazo)-N-ethylphenylamino)ethanol (Disperse Red 13) and its release from aqueous dispersions of microspheres with the different surface compositions was measured by spectrophotometry. The burst fraction, burst rate and the diffusion constant were determined from a model combining burst and diffusive release. Out of the three dispersants, the block copolymer gave the slowest release of the dye, with respect to both burst release and diffusive release. A very pronounced further reduction of the diffusion constant was obtained by applying polyelectrolyte multilayers on top of the microspheres. However, the diffusion constant was very weakly dependent on further polyelectrolyte adsorption and one polyelectrolyte bilayer appeared to suffice.
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| 2. |
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| 3. |
- Andersson, Helena, 1976-
(författare)
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Gotländska stenåldersstudier : Människor och djur, platser och landskap
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis deals mainly with the Middle Neolithic period (ca. 3200-2300 BC) on the island of Gotland in the Baltic Sea. The aim is to deepen the understanding of how the islanders related to their surroundings, to the landscape, to places, to objects, to animals and to humans, both living and dead. The archaeological material is studied downwards and up with a focus on practices, especially the handling and deposition of materials and objects in graves, within sites and in the landscape. The study is comparative and the Middle Neolithic is described in relation to the Early Neolithic and the Mesolithic period on the island.From a long term perspective the island is presented as a region where strong continuity can be identified, regarding both way of life and economy. In contrast, substantial changes did occur through time regarding the islander’s conceptions of the world and of social relations. This in turn affected the way they looked upon the landscape, different sites and animals, as well as other human beings. During the Mesolithic, the islanders first saw it as possible to create their world, their micro-cosmos, wherever they were, and they saw themselves as living in symbiosis with seals. With time, though, they started to relate, to connect and to identify themselves with the island, its landscape and its material, with axe sites and a growing group identity as results. The growing group identity culminated during the Early Neolithic with a dualistic conception of the world and with ritualised depositions in border zones.The Middle Neolithic is presented as a period when earlier boundaries were dissolved. This concerned, for example, boundaries towards the world around the islanders and they were no longer keeping themselves to their own sphere. At the same time individuals became socially important. It became accepted and also vital to give expression to personal identity, which was done through objects, materials and animals. Despite this, group identity continued to be an important part in their lives. This is most evident through the specific Pitted Ware sites, where the dead were also treated and buried. These places were sites for ritual and social practices, situated in visible, central and easy accessible locations, like gates in and out of the islands’ different areas. The dead were very important for the islanders. In the beginning of MN B they started to adopt aspects from the Battle Axe culture, but they never embraced Battle Axe grave customs. Instead they held on to the Pitted Ware way of dealing with the dead and buried, and to the Pitted Ware sites, through the whole period, with large burial grounds as a result.
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| 4. |
- Berg, Matilda, 1989-, et al.
(författare)
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Internet-based CBT for adolescents with low self-esteem : a pilot randomized controlled trial
- 2022
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Ingår i: Cognitive Behaviour Therapy. - : Routledge. - 1650-6073 .- 1651-2316. ; 51:5, s. 388-407
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Tidskriftsartikel (refereegranskat)abstract
- Low self-esteem is a common problem among adolescents and is related to psychiatric problems such as depression and anxiety. However, effective and available interventions primarily targeting low self-esteem are scarce, in particular for youths. To address this gap, the aim of this pilot study was to evaluate a novel internet-based Cognitive Behavioral Therapy (ICBT) program for low self-esteem in adolescents using a randomized controlled design. Fifty-two participants (15-19 years) were recruited and randomly allocated to seven weeks of therapist-supported ICBT (n=26) or to a waitlist control condition (n=26). The primary outcome was the Rosenberg Self-Esteem Scale (RSES). Secondary outcomes measured domain-specific aspects of self-esteem, self-compassion, quality of life, depression and anxiety. The treatment group showed significantly higher levels of self-rated self-esteem compared to the control group at post-treatment, with a large between-group effect-size (RSES, d = 1.18). Further, the treatment had significant positive impact on secondary measures of self-esteem, self-compassion, quality of life, depression and anxiety. The results of this pilot-RCT suggest that ICBT can be effective for treating low self-esteem in adolescents, decrease depression and anxiety levels, and increasing quality of life. Replication of the results in larger samples is needed.
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| 5. |
- Carlsson, Ylva, 1975, et al.
(författare)
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COVID-19 in Pregnancy and Early Childhood (COPE): study protocol for a prospective, multicentre biobank, survey and database cohort study.
- 2021
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 11:9
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Tidskriftsartikel (refereegranskat)abstract
- There is limited knowledge on how the SARS-CoV-2 affects pregnancy outcomes. Studies investigating the impact of COVID-19 in early pregnancy are scarce and information on long-term follow-up is lacking.The purpose of this project is to study the impact of COVID-19 on pregnancy outcomes and long-term maternal and child health by: (1) establishing a database and biobank from pregnant women with COVID-19 and presumably non-infected women and their infants and (2) examining how women and their partners experience pregnancy, childbirth and early parenthood in the COVID-19 pandemic.This is a national, multicentre, prospective cohort study involving 27 Swedish maternity units accounting for over 86000 deliveries/year. Pregnant women are included when they: (1) test positive for SARS-CoV-2 (COVID-19 group) or (2) are non-infected and seek healthcare at one of their routine antenatal visits (screening group). Blood, as well as other biological samples, are collected at different time points during and after pregnancy. Child health up to 4years of age and parent experience of pregnancy, delivery, early parenthood, healthcare and society in general will be examined using web-based questionnaires based on validated instruments. Short- and long-term health outcomes will be collected from Swedish health registers and the parents' experiences will be studied by performing qualitative interviews.Confidentiality aspects such as data encryption and storage comply with the General Data Protection Regulation and with ethical committee requirements. This study has been granted national ethical approval by the Swedish Ethical Review Authority (dnr 2020-02189 and amendments 2020-02848, 2020-05016, 2020-06696 and 2021-00870) and national biobank approval by the Biobank Väst (dnr B2000526:970). Results from the project will be published in peer-reviewed journals.NCT04433364.
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| 6. |
- Claeson, Magdalena, 1976, et al.
(författare)
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Incidence of cutaneous melanoma in Western Sweden, 1970-2007.
- 2012
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Ingår i: Melanoma research. - 1473-5636. ; 22:5, s. 392-8
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to describe the increasing incidence of cutaneous malignant melanoma (CMM) in Western Sweden during the period 1970-2007. A secondary aim was to show a geographical variation in incidence between coastal and inland areas, considering the effects of the local average duration of sunshine, and the sun exposure-related behavior in the populations. The Swedish Cancer Registry provided data on invasive melanomas during 1970-2007. Meteorological maps showed the annual average duration of sunshine during 1961-1990. A survey from 2007 with 2871 participants, carried out by the National Board of Health and Welfare, provided data on self-reported sun exposure. During the period studied, the age-standardized incidence for men in Western Sweden more than quadrupled to 31.1/100 000 inhabitants, whereas it tripled for women to 27.1/100 000. Coastal areas, including Gothenburg city, had a high average duration of sunshine (1701-1900 h of sun/year), whereas inland areas had lower average duration of sunshine (≤1700 h). The incidence of CMM was higher in coastal areas and in Gothenburg city, compared with inland areas. This may be linked to ultraviolet radiation, a consequence of the higher average duration of sunshine. The sun exposure survey showed additional factors, which possibly led to the increased incidence, for example high sun exposure on holidays abroad. The alarming increase in the incidence of CMM in Western Sweden, during the period 1970-2007, shows the need for additional primary preventive measures, for example sun protection programs targeted at populations in this area.
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| 7. |
- Gustafsson Asting, Annika, et al.
(författare)
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COX-2 Gene Expression in Colon Cancer Tissue related to Regulating Factors and Promoter Methylation Status
- 2011
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Ingår i: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Abstract Background Increased cyclooxygenase activity promotes progression of colorectal cancer, but the mechanisms behind COX-2 induction remain elusive. This study was therefore aimed to define external cell signaling and transcription factors relating to high COX-2 expression in colon cancer tissue. Method Tumor and normal colon tissue were collected at primary curative operation in 48 unselected patients. COX-2 expression in tumor and normal colon tissue was quantified including microarray analyses on tumor mRNA accounting for high and low tumor COX-2 expression. Cross hybridization was performed between tumor and normal colon tissue. Methylation status of up-stream COX-2 promoter region was evaluated. Results Tumors with high COX-2 expression displayed large differences in gene expression compared to normal colon. Numerous genes with altered expression appeared in tumors of high COX-2 expression compared to tumors of low COX-2. COX-2 expression in normal colon was increased in patients with tumors of high COX-2 compared to normal colon from patients with tumors of low COX-2. IL1β, IL6 and iNOS transcripts were up-regulated among external cell signaling factors; nine transcription factors (ATF3, C/EBP, c-Fos, Fos-B, JDP2, JunB, c-Maf, NF-κB, TCF4) showed increased expression and 5 (AP-2, CBP, Elk-1, p53, PEA3) were decreased in tumors with high COX-2. The promoter region of COX-2 gene did not show consistent methylation in tumor or normal colon tissue. Conclusions Transcription and external cell signaling factors are altered as covariates to COX-2 expression in colon cancer tissue, but DNA methylation of the COX-2 promoter region was not a significant factor behind COX-2 expression in tumor and normal colon tissue.
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| 8. |
- Jordan, Thomas, 1958, et al.
(författare)
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The Spectrum of Responses to Complex Societal Issues: Reflections on Seven Years of Empirical Inquiry
- 2013
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Ingår i: Integral Review. - 1553-3069. ; 9:1, s. 34-70
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Tidskriftsartikel (refereegranskat)abstract
- This article offers conclusions and reflections based on nine empirical studies carried out over the last seven years on how increased capacity to manage complex social issues can be scaffolded. Our focus has been on the role of meaning-making structures and transformations in individual and collective efforts to skillfully manage complex issues. We have studied capacities for managing complex issues both in terms of scaffolding group efforts through structured methods and facilitation and in terms of individual skills. Our action research gave us insights into the variability in scaffolding needs: groups are different in terms of the participants' meaning-making patterns, which means that methods and facilitation techniques should be adapted to the particular conditions in each case. We discuss variables describing group differences and offer a preliminary typology of functions that may need to be scaffolded. In a second major part of the article, we report on our learning about individual societal change agency. We offer a typology of four types of societal entrepreneurship and discuss in more detail the properties of dialectical meaning-making in societal change agency.
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| 9. |
- Sarén, Tina, et al.
(författare)
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Complementarity-determining region clustering may cause CAR-T cell dysfunction
- 2023
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1, s. 4732-
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Tidskriftsartikel (refereegranskat)abstract
- Chimeric antigen receptor (CAR)-T cell therapy is rapidly advancing as cancer treatment, however, designing an optimal CAR remains challenging. A single-chain variable fragment (scFv) is generally used as CAR targeting moiety, wherein the complementarity-determining regions (CDRs) define its specificity. We report here that the CDR loops can cause CAR clustering, leading to antigen-independent tonic signalling and subsequent CAR-T cell dysfunction. We show via CARs incorporating scFvs with identical framework and varying CDR sequences that CARs may cluster on the T cell surface, which leads to antigen-independent CAR-T cell activation, characterized by increased cell size and interferon (IFN)-γ secretion. This results in CAR-T cell exhaustion, activation-induced cell death and reduced responsiveness to target-antigen-expressing tumour cells. CDR mutagenesis confirms that the CAR-clustering is mediated by CDR-loops. In summary, antigen-independent tonic signalling can be induced by CDR-mediated CAR clustering, which could not be predicted from the scFv sequences, but could be tested for by evaluating the activity of unstimulated CAR-T cells.
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| 10. |
- Sternö, Linda, 1976, et al.
(författare)
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Vardagen under pandemin
- 2021
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Ingår i: Selma Center, Hisings Backa.
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- Utställningens tre fotografer skildrar livet under Covid. Att vara äldre i pandemin innebar för många en tid av isolering. Utställningen bjuder på humor och svärta och blir ett unikt tidsdokument av Hisings Backa under vintern 2021.
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