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- Greiff, Lennart, et al.
(författare)
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Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis
- 2012
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Ingår i: Respiratory Research. - : Springer Science and Business Media LLC. - 1465-9921. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- Background: Interactions between Th1 and Th2 immune responses are of importance to the onset and development of allergic disorders. A Toll-like receptor 7 agonist such as AZD8848 may have potential as a treatment for allergic airway disease by skewing the immune system away from a Th2 profile. Objective: To evaluate the efficacy and safety of intranasal AZD8848. Methods: In a placebo-controlled single ascending dose study, AZD8848 (0.3-600 mu g) was given intranasally to 48 healthy subjects and 12 patients with allergic rhinitis (NCT00688779). In a placebo-controlled repeat challenge/treatment study, AZD8848 (30 and 60 mu g) was given once weekly for five weeks to 74 patients with allergic rhinitis out of season: starting 24 hours after the final dose, daily allergen challenges were given for seven days (NCT00770003). Safety, tolerability, pharmacokinetics, and biomarkers were monitored. During the allergen challenge series, nasal symptoms and lavage fluid levels of tryptase and alpha(2)-macroglobulin, reflecting mast cell activity and plasma exudation, were monitored. Results: AZD8848 produced reversible blood lymphocyte reductions and dose-dependent flu-like symptoms: 30100 mu g produced consistent yet tolerable effects. Plasma interleukin-1 receptor antagonist was elevated after administration of AZD8848, reflecting interferon production secondary to TLR7 stimulation. At repeat challenge/treatment, AZD8848 reduced nasal symptoms recorded ten minutes after allergen challenge up to eight days after the final dose. Tryptase and a2-macroglobulin were also reduced by AZD8848. Conclusions: Repeated intranasal stimulation of Toll-like receptor 7 by AZD8848 was safe and produced a sustained reduction in the responsiveness to allergen in allergic rhinitis.
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- Uhlén, Mathias, et al.
(författare)
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A human protein atlas for normal and cancer tissues based on antibody proteomics
- 2005
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Ingår i: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 4:12, s. 1920-1932
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Tidskriftsartikel (refereegranskat)abstract
- Antibody-based proteomics provides a powerful approach for the functional study of the human proteome involving the systematic generation of protein-specific affinity reagents. We used this strategy to construct a comprehensive, antibody-based protein atlas for expression and localization profiles in 48 normal human tissues and 20 different cancers. Here we report a new publicly available database containing, in the first version, similar to 400,000 high resolution images corresponding to more than 700 antibodies toward human proteins. Each image has been annotated by a certified pathologist to provide a knowledge base for functional studies and to allow queries about protein profiles in normal and disease tissues. Our results suggest it should be possible to extend this analysis to the majority of all human proteins thus providing a valuable tool for medical and biological research.
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- Westerlund, Tommy, 1952, et al.
(författare)
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Evaluation of a model for counseling patients with dyspepsia in Swedish community pharmacies.
- 2003
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Ingår i: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. - 1079-2082. ; 60:13, s. 1336-1341
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Tidskriftsartikel (refereegranskat)abstract
- The outcomes of a counseling model designed to help pharmacists care for customers seeking nonprescription treatment for dyspepsia in Swedish community pharmacies were studied. A protocol containing 10 key questions based on clinical guidelines about dyspepsia symptoms and on studies of drug-related problems (DRPs) was implemented in six community pharmacies in Sweden. During two weeks in April 2002, all adult customers seeking self-care for dyspepsia were asked to participate in the interview. Depending on a customer's answers, pharmacy personnel gave advice, intervened for DRPs, or referred the customer to a physician. Customers who received advice or intervention were followed up by telephone. A total of 319 customers who met the study criteria agreed to participate. Of these, 183 (57%) received self-care advice, 37 (12%) had DRPs, and 39 (12%) were referred to a physician because of their symptoms. Of the 198 customers fulfilling the criteria for a follow-up interview, 130 (66%) participated. Nearly all of these customers were satisfied with their visit to the pharmacy, and 9 in 10 were pleased with the advice received. Eighty-five percent claimed they had followed the self-care advice, and two in three said they felt better. DRPs were resolved in 19 (86%) of the 22 customers with DRPs who were followed up. Only one customer in five who was advised to see a physician actually did so. A counseling model designed to discover and resolve problems related to symptoms and drug use appeared to have a favorable impact on outcomes in customers with dyspepsia seeking nonprescription drug treatment in Swedish pharmacies.
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- Westerlund, Tommy, 1952, et al.
(författare)
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The quality of self-care counselling by pharmacy practitioners, supported by IT-based clinical guidelines.
- 2007
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Ingår i: Pharmacy world & science : PWS. - : Springer Science and Business Media LLC. - 0928-1231 .- 1573-739X. ; 29:2, s. 67-72
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The primary objective of the study was to assess the quality of self-care counselling from pharmacy practitioners, supported by national clinical guidelines. The research questions addressed (1) the distribution of symptoms among customers in need of self-care counselling, (2) the quality of the self-care advice provided by pharmacy practitioners, (3) the degree of customer compliance with appropriate pharmacy advice versus the extent of symptom relief, (4) and versus a subsequent medical care visit, and (5) which resource the customers would have turned to in the first place for their ailments, had the pharmacy practitioner not been available. SETTING: Three large community pharmacies with non-prescription self-selection departments in central Sweden. METHODS: Ten pharmacy practitioners counselled all customers > or = 18 years old, with whom a dialogue was initiated on advice or products for self-care. The counselling was based on national clinical guidelines for self-care advice in the form of a software decision support program. The data collection consisted of documentation of background customer information, independent assessments of the quality of the advice provided and of telephone follow-ups. RESULTS: Of all documented symptoms (n = 250), the most common were allergy (26.4%), musculoskeletal symptoms (8.4%) and dyspepsia (7.2%). Independent assessments of the documentation by a physician and a pharmacist found that self-care advice was appropriate to give 97.6% of the customers and that the advice provided was correct in 88.4% of the cases. In total, 217 cases (86.8%) were fully approved by both the physician and the pharmacist. Among the 182 customers who claimed that they complied completely with appropriate advice provided, 135 (74.2%) experienced a great improvement in symptoms. Among the 21 who had only partly followed the advice, six (28.6%) reported the same level of improvement (p < 0.001). If the pharmacy practitioner had not been available, 56.8% of the customers would have turned to medical care in the first instance. CONCLUSIONS: The study demonstrates the high quality of pharmacy practitioners' self-care counselling supported by IT-based national clinical guidelines, including a favourable impact on customers' ailments. Furthermore, it reveals that pharmacy practitioners greatly relieve the pressure on the health-care system, resulting in reduced costs to society.
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