| 1. |
- Walley, A J, et al.
(författare)
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Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue.
- 2012
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Ingår i: International Journal of Obesity. - : Springer Science and Business Media LLC. - 1476-5497 .- 0307-0565. ; 36:1, s. 137-147
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Tidskriftsartikel (refereegranskat)abstract
- Objective:To use a unique obesity-discordant sib-pair study design to combine differential expression analysis, expression quantitative trait loci (eQTLs) mapping and a coexpression regulatory network approach in subcutaneous human adipose tissue to identify genes relevant to the obese state.Study design:Genome-wide transcript expression in subcutaneous human adipose tissue was measured using Affymetrix U133 Plus 2.0 microarrays (Affymetrix, Santa Clara, CA, USA), and genome-wide genotyping data was obtained using an Applied Biosystems (Applied Biosystems; Life Technologies, Carlsbad, CA, USA) SNPlex linkage panel.Subjects:A total of 154 Swedish families ascertained through an obese proband (body mass index (BMI) >30kgm(-2)) with a discordant sibling (BMI>10kgm(-2) less than proband).Results:Approximately one-third of the transcripts were differentially expressed between lean and obese siblings. The cellular adhesion molecules (CAMs) KEGG grouping contained the largest number of differentially expressed genes under cis-acting genetic control. By using a novel approach to contrast CAMs coexpression networks between lean and obese siblings, a subset of differentially regulated genes was identified, with the previously GWAS obesity-associated neuronal growth regulator 1 (NEGR1) as a central hub. Independent analysis using mouse data demonstrated that this finding of NEGR1 is conserved across species.Conclusion:Our data suggest that in addition to its reported role in the brain, NEGR1 is also expressed in subcutaneous adipose tissue and acts as a central 'hub' in an obesity-related transcript network.
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| 2. |
- Jakobsen, A M, et al.
(författare)
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Differential expression of vesicular monoamine transporter (VMAT) 1 and 2 in gastrointestinal endocrine tumours.
- 2001
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Ingår i: The Journal of pathology. - : Wiley. - 0022-3417. ; 195:4, s. 463-72
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Tidskriftsartikel (refereegranskat)abstract
- Neuroendocrine tumours are characterized by their capacity to produce hormones, which are stored in vesicles and secretory granules. Demonstration of granule/vesicle proteins in tumours is taken as evidence of neuroendocrine differentiation. Vesicular monoamine transporters (VMAT1 and VMAT2) mediate the transport of amines into vesicles of neurons and endocrine cells. The expression of VMAT1 and VMAT2 and the usefulness of VMAT1 and VMAT2 in the histopathological diagnosis of gastrointestinal endocrine tumours have not been fully explored. This study therefore investigated the expression of VMAT1 and VMAT2 in 211 human gastrointestinal tumours by immunocytochemistry and western blotting. VMAT1 and/or VMAT2 were demonstrated in the majority of amine-producing endocrine tumours of gastric, ileal, and appendiceal origin. Serotonin-producing endocrine tumours (ileal and appendiceal carcinoids) expressed predominantly VMAT1, while histamine-producing endocrine tumours (gastric carcinoids) expressed VMAT2 almost exclusively. In peptide-producing endocrine tumours such as rectal carcinoids and endocrine pancreatic tumours, only a small number of immunopositive tumour cells were observed. No labelling was found in non-endocrine tumours, including gastric, colorectal and pancreatic adenocarcinomas and gastrointestinal stromal tumours. In conclusion, VMAT1 and VMAT2 are differentially expressed by gastrointestinal endocrine tumours, with a pattern specific for each tumour type, reflecting their neuroendocrine differentiation and origin. VMAT1 and VMAT2 may therefore become valuable markers in the classification of neuroendocrine tumours and may also indicate patients suitable for radioisotope treatment operating via these transporter systems.
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| 3. |
- Ahlin, Sofie, 1985, et al.
(författare)
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Macrophage Gene Expression in Adipose Tissue is Associated with Insulin Sensitivity and Serum Lipid Levels Independent of Obesity.
- 2013
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Ingår i: Obesity (Silver Spring, Md.). - : Wiley. - 1930-739X .- 1930-7381. ; 21:12
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Obesity is linked to both increased metabolic disturbances and increased adipose tissue macrophage infiltration. However, whether macrophage infiltration directly influences human metabolism is unclear. The aim of this study was to investigate if there are obesity-independent links between adipose tissue macrophages and metabolic disturbances. Design and Methods: Expression of macrophage markers in adipose tissue was analyzed by DNA microarrays in the SOS Sib Pair study and in patients with type 2 diabetes and a BMI-matched healthy control group. Results: The expression of macrophage markers in adipose tissue was increased in obesity and associated with several metabolic and anthropometric measurements. After adjustment for BMI, the expression remained associated with insulin sensitivity, serum levels of insulin, C-peptide, high density lipoprotein cholesterol (HDL-cholesterol) and triglycerides. In addition, the expression of most macrophage markers was significantly increased in patients with type 2 diabetes compared to the control group. Conclusion: Our study shows that infiltration of macrophages in human adipose tissue, estimated by the expression of macrophage markers, is increased in subjects with obesity and diabetes and associated with insulin sensitivity and serum lipid levels independent of BMI. This indicates that adipose tissue macrophages may contribute to the development of insulin resistance and dyslipidemia.
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| 4. |
- Andersson, Lars M, 1961-, et al.
(författare)
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Alvar Alsterdal - : en introduktion
- 2020
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Ingår i: Antisemitism Antisionism.. - Malmö : Égalité. - 9789198420371 ; , s. 17-54
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Alsterdals bok gavs ursprungligen ut 1969. Den skildrar den våg av antisemitism i Polen som utlöstes efter junikriget 1967 mellan Israel och dess grannländer. Till nyutgåvan har historikern Lars M Andersson skrivit en utförlig introduktion om Alstersdals yrkesliv och författarskap, där arbetarrörelsen, europeisk kultur samt det judiska folkets historia och öden utgör centrala teman. I nyutgåvan finns två efterskrifter av Lars Dencik resp. Weddig Runquist.
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| 5. |
- Andersson, Lars M, 1961-, et al.
(författare)
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Antisemitismen : antirasismens blinda fläck?
- 2017
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Ingår i: Från Afrikakompaniet till Tokyo. - Stockholm : Bokförlaget Exkurs. - 9789177733942
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Andersson, Lars M, 1961-
(författare)
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Blixten (Schweden)
- 2013
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Ingår i: Handbuch des Antisemitismus. - Berlin : Walter de Gruyter.
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Bokkapitel (refereegranskat)
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| 7. |
- Andersson, Lars M, 1961-
(författare)
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En orättvis betraktelse
- 2018
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Ingår i: Nyhetsbrev. Svenska kommittén mot antisemitism Juni 2018. - Stockholm. ; , s. 6-7
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Recension (populärvet., debatt m.m.)
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| 8. |
- Andersson, Lars M, 1961-
(författare)
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Express-zionisten Isaac och den svenska nationen
- 2022
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Ingår i: Issac Grünewald - konst och teater. - Stockholm : Prins Eugenes Waldemarsudde. - 9789186265588
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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